Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P. World Stroke Organization (WSO): global stroke fact sheet 2022. Int J Stroke. 2022;17(1):18–29.

PubMed  Google Scholar 

Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, et al. Heart disease and stroke statistics-2023 update: a report from the American Heart Association. Circulation. 2023;147(8):e93–621.

PubMed  Google Scholar 

Martin SS, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Barone Gibbs B, Beaton AZ, Boehme AK, et al. 2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2024;149(8):e347–913.

PubMed  Google Scholar 

Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18(4):394–405.

PubMed  Google Scholar 

Wilson MP, Plecko B, Mills PB, Clayton PT. Disorders affecting vitamin B(6) metabolism. J Inherit Metab Dis. 2019;42(4):629–46.

CAS  PubMed  Google Scholar 

Minović I, Kieneker LM, Gansevoort RT, Eggersdorfer M, Touw DJ, Voerman AJ, Connelly MA, Boer RA, Hak E, Bos J, et al. Vitamin B6, inflammation, and cardiovascular outcome in a population-based cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Nutrients. 2020;12(9):2711.

PubMed  PubMed Central  Google Scholar 

Mocellin S, Briarava M, Pilati P. Vitamin B6 and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst. 2017;109(3):1–9.

PubMed  Google Scholar 

Del Bo C, Riso P, Gardana C, Brusamolino A, Battezzati A, Ciappellano S. Effect of two different sublingual dosages of vitamin B(12) on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: a randomized controlled trial. Clin Nutr. 2019;38(2):575–83.

PubMed  Google Scholar 

Kato N, Kimoto A, Zhang P, Bumrungkit C, Karunaratne S, Yanaka N, Kumrungsee T. Relationship of low vitamin B6 status with sarcopenia, frailty, and mortality: a narrative review. Nutrients. 2024;16(1):177.

CAS  PubMed  PubMed Central  Google Scholar 

Hankey GJ. B vitamins for stroke prevention. Stroke Vasc Neurol. 2018;3(2):51–8.

PubMed  PubMed Central  Google Scholar 

Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141.

PubMed  PubMed Central  Google Scholar 

Wang C, Li B, Zhu Q, Zhang Q, Xie Z, Xie H, Li X. Dietary vitamin B6 intake and stroke are negatively associated in adults: a cross-sectional study from the NHANES. Heliyon. 2024;10(10):e31125.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang B, Dong H, Xu Y, Xu D, Sun H, Han L. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77(3):299–307.

CAS  PubMed  Google Scholar 

Ueland PM, McCann A, Midttun Ø, Ulvik A. Inflammation, vitamin B6 and related pathways. Mol Aspects Med. 2017;53:10–27.

CAS  PubMed  Google Scholar 

Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, Matavulj A, Djuric DM. Homocysteine, vitamins B6 and folic acid in experimental models of myocardial infarction and heart failure-how strong is that link? Biomolecules. 2022;12(4):536.

CAS  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Peana M, Dadar M, Lozynska I, Chirumbolo S, Lysiuk R, Lenchyk L, Upyr T, Severin B. The role of B vitamins in stroke prevention. Crit Rev Food Sci Nutr. 2022;62(20):5462–75.

PubMed  Google Scholar 

Al Mughram MH, Ghatge MS, Kellogg GE, Safo MK. Elucidating the interaction between pyridoxine 5’-phosphate oxidase and dopa decarboxylase: activation of B6-dependent enzyme. Int J Mol Sci. 2022;24(1):642.

PubMed  PubMed Central  Google Scholar 

Bisello G, Ribeiro RP, Perduca M, Belviso BD, Polverino De’Laureto P, Giorgetti A, Caliandro R, Bertoldi M. Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: implication in aromatic amino acid decarboxylase deficiency. Protein Sci. 2023;32(8):e4732.

CAS  PubMed  PubMed Central  Google Scholar 

Shah AK, Dhalla NS. Effectiveness of some vitamins in the prevention of cardiovascular disease: a narrative review. Front Physiol. 2021;12:729255.

PubMed  PubMed Central  Google Scholar 

Paez-Hurtado AM, Calderon-Ospina CA, Nava-Mesa MO. Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review. Nutr Neurosci. 2023;26(3):235–53.

CAS  PubMed  Google Scholar 

Zhang N, Wu Z, Bai X, Song Y, Li P, Lu X, Huo Y, Zhou Z. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119(3):821–8.

CAS  PubMed  Google Scholar 

Mascolo E, Vernì F. Vitamin B6 and diabetes: relationship and molecular mechanisms. Int J Mol Sci. 2020;21(10):3669.

CAS  PubMed  PubMed Central  Google Scholar 

Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients. 2021;13(9):3229.

CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Glubb DM, O’Mara TA. Dietary factors and endometrial cancer risk: a Mendelian randomization study. Nutrients. 2023;15(3):603.

CAS  PubMed  PubMed Central  Google Scholar 

Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19(1):97.

CAS  PubMed  PubMed Central  Google Scholar 

Li J, Song F. A causal relationship between antioxidants, minerals and vitamins and metabolic syndrome traits: a Mendelian randomization study. Diabetol Metab Syndr. 2023;15(1):194.

CAS  PubMed  PubMed Central  Google Scholar 

Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016;27(11):3253–65.

PubMed  PubMed Central  Google Scholar 

Kintu C, Soremekun O, Kamiza AB, Kalungi A, Mayanja R, Kalyesubula R, Bagaya SB, Jjingo D, Fabian J, Gill D, et al. The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study. EBioMedicine. 2023;90:104537.

CAS  PubMed  PubMed Central  Google Scholar 

Israr MZ, Bernieh D, Salzano A, Cassambai S, Yazaki Y, Heaney LM, Jones DJL, Ng LL, Suzuki T. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 2021;234:71–80.

CAS  PubMed  Google Scholar 

Bubnov RV, Spivak MY, Lazarenko LM, Bomba A, Boyko NV. Probiotics and immunity: provisional role for personalized diets and disease prevention. EPMA J. 2015;6(1):14.

PubMed  PubMed Central  Google Scholar 

National Center for Health Statistics. [https://www.cdc.gov/nchs/nhanes/about_nhanes.htm]. Accessed 5 May 2023.

Fan Y, Song Z, Zhang M. Emerging frontiers of artificial intelligence and machine learning in ischemic stroke: a comprehensive investigation of state-of-the-art methodologies, clinical applications, and unraveling challenges. EPMA J. 2023;14(4):645–61.

PubMed  PubMed Central  Google Scholar 

Crigna AT, Samec M, Koklesova L, Liskova A, Giordano FA, Kubatka P, Golubnitschaja O. Cell-free nucleic acid patterns in disease prediction and monitoring-hype or hope? EPMA J. 2020;11(4):603–27.

PubMed  PubMed Central  Google Scholar 

Ueland PM, Ulvik A, Rios-Avila L, Midttun Ø, Gregory JF. Direct and functional biomarkers of vitamin B6 status. Annu Rev Nutr. 2015;35:33–70.

CAS  PubMed  PubMed Central  Google Scholar 

Koklesova L, Mazurakova A, Samec M, Biringer K, Samuel SM, Büsselberg D, Kubatka P, Golubnitschaja O. Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person. EPMA J. 2021;12(4):477–505.

PubMed  PubMed Central  Google Scholar 

Fay MP, Proschan MA. Wilcoxon-Mann-Whitney or t-test? On assumptions for hypothesis tests and multiple interpretations of decision rules. Statist Surv. 2010;4:1–39.

Kropp M, Golubnitschaja O, Mazurakova A, Koklesova L, Sargheini N, Vo T-TKS, de Clerck E, Polivka J, Potuznik P, Polivka J et al. Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications-risks and mitigation. EPMA J. 2023;14(1):21–42.

Zhang Y, Wang F, Tang J, Shen L, He J, Chen Y. Association of triglyceride glucose-related parameters with all-cause mortality and cardiovascular disease in NAFLD patients: NHANES 1999–2018. Cardiovasc Diabetol. 2024;23(1):262.

CAS  PubMed  PubMed Central