Identifying Specificity Protein 2 as a key marker for diabetic encephalopathy in the context of predictive, preventive, and personalized medicine

Saltiel AR. Insulin signaling in health and disease. J Clin Invest. 2021;131(1):e142241.

CAS  PubMed  PubMed Central  Google Scholar 

Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98(4):2133–223.

CAS  PubMed  PubMed Central  Google Scholar 

Bedinger DH, Adams SH. Metabolic, anabolic, and mitogenic insulin responses: a tissue-specific perspective for insulin receptor activators. Mol Cell Endocrinol. 2015;415:143–56.

CAS  PubMed  Google Scholar 

Xu J, Cai S, Zhao J, Xu K, Ji H, Wu C, Xiao J, Wu Y. Advances in the relationship between pyroptosis and diabetic neuropathy. Front Cell Dev Biol. 2021;9:753660.

PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, Krapfenbauer K, Mozaffari MS, Costigliola V. Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016. EPMA J. 2016;7(1):23.

PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Costigliola V, Epma. General report & recommendations in predictive, preventive and personalised medicine 2012: white paper of the European Association for Predictive Preventive and Personalised Medicine. EPMA J. 2012;3(1):14.

PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Watson ID, Topic E, Sandberg S, Ferrari M, Costigliola V. Position paper of the EPMA and EFLM: a global vision of the consolidated promotion of an integrative medical approach to advance health care. EPMA J. 2013;4(1):12.

PubMed  PubMed Central  Google Scholar 

Mazumdar D, Singh S. Diabetic encephalopathy: role of oxidative and nitrosative factors in type 2 diabetes. Indian J Clin Biochem. 2024;39(1):3–17.

CAS  PubMed  Google Scholar 

Zhang D, Jiang S, Meng H. Role of the insulin-like growth factor type 1 receptor in the pathogenesis of diabetic encephalopathy. Int J Endocrinol. 2015;2015:626019.

PubMed  PubMed Central  Google Scholar 

Schemmel KE, Padiyara RS, D’Souza JJ. Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. J Diabetes Complications. 2010;24(5):354–60.

PubMed  Google Scholar 

Li J, Xu S, Wang L, Wang X. PHPB attenuated cognitive impairment in type 2 diabetic KK-Ay mice by modulating SIRT1/insulin signaling pathway and inhibiting generation of AGEs. Pharmaceuticals (Basel). 2023;16(2):305.

CAS  PubMed  Google Scholar 

Nagayach A, Bhaskar R, Ghosh S, Singh KK, Han SS, Sinha JK. Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives. Ageing Res Rev. 2024;100:102450.

CAS  PubMed  Google Scholar 

Safe S, Abdelrahim M. Sp transcription factor family and its role in cancer. Eur J Cancer. 2005;41(16):2438–48.

CAS  PubMed  Google Scholar 

Chu S. Transcriptional regulation by post-transcriptional modification–role of phosphorylation in Sp1 transcriptional activity. Gene. 2012;508(1):1–8.

CAS  PubMed  Google Scholar 

Xie J, Yin H, Nichols TD, Yoder JA, Horowitz JM. Sp2 is a maternally inherited transcription factor required for embryonic development. J Biol Chem. 2010;285(6):4153–64.

CAS  PubMed  Google Scholar 

Kingsley C, Winoto A. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol. 1992;12(10):4251–61.

CAS  PubMed  PubMed Central  Google Scholar 

Ratajewski M, Walczak-Drzewiecka A, Gorzkiewicz M, Sałkowska A, Dastych J. Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor. J Leukoc Biol. 2016;100(5):1213–23.

CAS  PubMed  Google Scholar 

Zhao LY, Yao Y, Han J, Yang J, Wang XF, Tong DD, Song TS, Huang C, Shao Y. miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2. Dig Dis Sci. 2014;59(8):1743–53.

CAS  PubMed  Google Scholar 

Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina IN, Kozikowski AP, Singh SK, Fink D, Ströbel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress TM, Ellenrieder V, Neesse A. GSK-3β Governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression. Mol Cancer Ther. 2016;15(3):491–502.

CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Cui J, Liu J, Hua W, Wei W, Sun G. Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein. Cancer Med. 2020;9(10):3592–603.

CAS  PubMed  PubMed Central  Google Scholar 

Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. Cancer Res. 2004;64(9):3072–8.

CAS  PubMed  Google Scholar 

Terrados G, Finkernagel F, Stielow B, Sadic D, Neubert J, Herdt O, Krause M, Scharfe M, Jarek M, Suske G. Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Nucleic Acids Res. 2012;40(16):7844–57.

CAS  PubMed  PubMed Central  Google Scholar 

Baur F, Nau K, Sadic D, Allweiss L, Elsässer HP, Gillemans N, de Wit T, Krüger I, Vollmer M, Philipsen S, Suske G. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587.

PubMed  PubMed Central  Google Scholar 

Da CM, Liao HY, Deng YS, Zhao GH, Ma L, Zhang HH. Transcription factor SP2 regulates ski-mediated astrocyte proliferation in vitro. Neuroscience. 2021;479:22–34.

CAS  PubMed  Google Scholar 

Allenby MC, Woodruff MA. Image analyses for engineering advanced tissue biomanufacturing processes. Biomaterials. 2022;284:121514.

CAS  PubMed  Google Scholar 

Lu T, Yang B, Wang R, Qin C. Xenotransplantation: current status in preclinical research. Front Immunol. 2019;10:3060.

CAS  PubMed  Google Scholar 

Nithin R, Aggarwal A, Sravani AB, Mallya P, Lewis S. Organ-on-a-chip: an emerging research platform. Organogenesis. 2023;19(1):2278236.

Google Scholar 

Maqsood MI, Matin MM, Bahrami AR, Ghasroldasht MM. Immortality of cell lines: challenges and advantages of establishment. Cell Biol Int. 2013;37(10):1038–45.

PubMed  Google Scholar 

Saeidnia S, Manayi A, Abdollahi M. From in vitro experiments to in vivo and clinical studies; pros and cons. Curr Drug Discov Technol. 2015;12(4):218–24.

CAS  PubMed  Google Scholar 

Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, Niu Y, Du L. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10.

PubMed  Google Scholar 

Hoyer S. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J Neural Transm (Vienna). 1998;105(4–5):415–22.

CAS  PubMed  Google Scholar 

Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, McGovern P, Folsom AR. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology. 2001;56(1):42–8.

CAS  PubMed  Google Scholar 

Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87(1):315–424.

CAS  PubMed  Google Scholar 

Díaz-Gerevini GT, Daín A, Pasqualini ME, López CB, Eynard AR, Repossi G. Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model. Lipids Health Dis. 2019;18(1):43.

PubMed  PubMed Central  Google Scholar 

Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer’s disease in aged mice. Eur J Neurosci. 2004;19(10):2826–38.

PubMed  Google Scholar 

Mamiya T, Noda Y, Nishi M, Takeshima H, Nabeshima T. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. Brain Res. 1998;783(2):236–40.

CAS  PubMed  Google Scholar 

Kraeuter AK, Guest PC, Sarnyai Z. The Y-maze for assessment of spatial working and reference memory in mice. Methods Mol Biol. 2019;1916:105–11.

CAS  PubMed 

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