Agarwal V, Bell GW, Nam JW, Bartel DP (2015) Predicting effective microRNA target sites in mammalian mRNAs. Elife 4:e05005

Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Sudhof TC, Wernig M (2016) FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci U S A 113:8514–8519

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barletta M, Reed R (2019) Local anesthetics: pharmacology and special preparations. Vet Clin North Am Small Anim Pract 49:1109–1125

Article  PubMed  Google Scholar 

Bhargava S, Patil V, Mahalingam K, Somasundaram K (2017) Elucidation of the genetic and epigenetic landscape alterations in RNA binding proteins in glioblastoma. Oncotarget 8:16650–16668

Article  PubMed  Google Scholar 

Cao G, Lin M, Gu W, Su Z, Duan Y, Song W, Liu H, Zhang F (2023) The rules and regulatory mechanisms of FOXO3 on inflammation, metabolism, cell death and aging in hosts. Life Sci 328:121877

Article  PubMed  CAS  Google Scholar 

Castro-Mondragon JA, Riudavets-Puig R, Rauluseviciute I, Lemma RB, Turchi L, Blanc-Mathieu R, Lucas J, Boddie P, Khan A, Manosalva Perez N, Fornes O, Leung TY, Aguirre A, Hammal F, Schmelter D, Baranasic D, Ballester B, Sandelin A, Lenhard B, Vandepoele K, Wasserman WW, Parcy F, Mathelier A (2022) JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res 50:D165–D173

Article  PubMed  CAS  Google Scholar 

Chen L, Zhuang K (2023) Kaempferol counteracts bupivacaine-induced neurotoxicity in mouse dorsal root ganglia neurons by regulating TRAF6-dependent NF-kappaB signaling. Kaohsiung J Med Sci 39:710–717

Article  PubMed  CAS  Google Scholar 

Chen Y, Gao X, Pei H (2022) miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats. Brain Behav 12:e2556

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Y, Yan L, Zhang Y, Yang X (2019) The role of DRP1 in ropivacaine-induced mitochondrial dysfunction and neurotoxicity. Artif Cells Nanomed Biotechnol 47:1788–1796

Article  PubMed  CAS  Google Scholar 

Contino V, Abrams JH, Arumugam S, Sinha SK, Vellanky SS, Cremins MS, McCann GP (2021) Spinal anesthesia using ropivacaine leads to earlier ambulation after total hip arthroplasty. Orthopedics 44:e343–e346

Article  PubMed  Google Scholar 

Deng Y, Ma G, Gao F, Sun X, Liu L, Mo D, Ma N, Song L, Huo X, He H, Miao Z (2020) SOX9 Knockdown-mediated FOXO3 downregulation confers neuroprotection against ischemic brain injury. Front Cell Dev Biol 8:555175

Article  PubMed  Google Scholar 

Diener C, Keller A, Meese E (2022) Emerging concepts of miRNA therapeutics: from cells to clinic. Trends Genet 38:613–626

Article  PubMed  CAS  Google Scholar 

Fang C, Gu L, Smerin D, Mao S, Xiong X (2017) The interrelation between reactive oxygen species and autophagy in neurological disorders. Oxid Med Cell Longev 2017:8495160

Article  PubMed  PubMed Central  Google Scholar 

Feng G, Wang Y, Feng J, Luo X, Li C, Yao S (2021) The relationship between core temperature and perioperative shivering during caesarean section under intrathecal anesthesia with bupivacaine and ropivacaine: a randomized controlled study. J Anesth 35:889–895

Article  PubMed  PubMed Central  Google Scholar 

Guo D, Ma J, Li T, Yan L (2018) Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-kappaB pathway by targeting FOXO3. Exp Cell Res 369:34–42

Article  PubMed  CAS  Google Scholar 

Hampl K, Steinfeldt T, Wulf H (2014) Spinal anesthesia revisited: toxicity of new and old drugs and compounds. Curr Opin Anaesthesiol 27:549–555

Article  PubMed  CAS  Google Scholar 

Izumi Y, Izumi M, Benz AM, Zorumski CF (2001) Lactate dehydrogenase release is facilitated by brief sonication of rat hippocampal slices and isolated retinas following acute neuronal damage. J Neurosci Methods 108:49–55

Article  PubMed  CAS  Google Scholar 

Jiang T, Xu S, Shen Y, Xu Y, Li Y (2021) Genistein attenuates isoflurane-induced neuroinflammation by inhibiting TLR4-mediated microglial-polarization in vivo and in vitro. J Inflamm Res 14:2587–2600

Article  PubMed  PubMed Central  Google Scholar 

Li JH, Liu S, Zhou H, Qu LH, Yang JH (2014) starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 42:D92-97

Article  PubMed  CAS  Google Scholar 

Li W, Zhu Q, Xu X, Hu X (2021) MiR-27a-3p suppresses cerebral ischemia-reperfusion injury by targeting FOXO1. Aging (Albany NY) 13:11727–11737

Article  PubMed  CAS  Google Scholar 

Lin J, Li G, Xu C, Lu H, Zhang C, Pang Z, Liu Z (2020) Monocyte chemotactic protein 1-induced protein 1 is highly expressed in inflammatory bowel disease and negatively regulates neutrophil activities. Mediators Inflamm 2020:8812020

Article  PubMed  PubMed Central  Google Scholar 

Lirk P, Picardi S, Hollmann MW (2014) Local anaesthetics: 10 essentials. Eur J Anaesthesiol 31:575–585

Article  PubMed  CAS  Google Scholar 

Liu Y, Dong ZJ, Song JW, Liang LR, Sun LL, Liu XY, Miao R, Xu YL, Li XT, Zhang MW, Zhang ZZ, Zhong JC (2022) MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3. Exp Cell Res 411:113017

Article  PubMed  CAS  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408

Article  PubMed  CAS  Google Scholar 

Lu H, Chen Y, Wang X, Yang Y, Ding M, Qiu F (2022) Circular RNA HIPK3 aggravates sepsis-induced acute kidney injury via modulating the microRNA-338/forkhead box A1 axis. Bioengineered 13:4798–4809

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lu Y, Cao DL, Jiang BC, Yang T, Gao YJ (2015) MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord. Brain Behav Immun 49:119–129

Article  PubMed  CAS  Google Scholar 

Mao X, Wu Y, Xu W (2023) miR-126-5p expression in the plasma of patients with sepsis-induced acute lung injury and its correlation with inflammation and immune function. Clin Respir J 17:629–637

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan J, Qu M, Li Y, Wang L, Zhang L, Wang Y, Tang Y, Tian HL, Zhang Z, Yang GY (2020) MicroRNA-126-3p/-5p overexpression attenuates blood-brain barrier disruption in a mouse model of middle cerebral artery occlusion. Stroke 51:619–627

Article  PubMed  CAS  Google Scholar 

Park HH (2018) Structure of TRAF family: current understanding of receptor recognition. Front Immunol 9:1999

Article  PubMed  PubMed Central  Google Scholar 

Qin Z, Zhu G, Luo H, Deng Y (2022) Regulation of FOXO3 on neuronal ferroptosis after intracerebral hemorrhage via modulating NOX4 transcription. Eur Surg Res. https://doi.org/10.1159/000527617

Article  PubMed  Google Scholar 

Roux PP, Barker PA (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67:203–233

Article  PubMed  CAS  Google Scholar 

Santo EE, Paik J (2018) FOXO in neural cells and diseases of the nervous system. Curr Top Dev Biol 127:105–118

Article