Impact of vitamins A, D, and homocysteine on cardiometabolic multimorbidity in Northwest China

Fabbri E, Zoli M, Gonzalez-Freire M, Salive ME, Studenski SA, Ferrucci L. Aging and multimorbidity: New tasks, priorities, and Frontiers for Integrated Gerontological and Clinical Research. J Am Med Dir Assoc. 2015;16(8):640–7. https://doi.org/10.1016/j.jamda.2015.03.013.

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Atun R, Oldenburg B, McPake B, Tang S, Mercer SW, et al. Physical multimorbidity, health service use, and catastrophic health expenditure by socioeconomic groups in China: an analysis of population-based panel data. Lancet Glob Health. 2020;8(6):e840. https://doi.org/10.1016/s2214-109x(20)30127-3.

Article  PubMed  PubMed Central  Google Scholar 

Busija L, Lim K, Szoeke C, Sanders KM, McCabe MP. Do replicable profiles of multimorbidity exist? Systematic review and synthesis. Eur J Epidemiol. 2019;34(11):1025–53. https://doi.org/10.1007/s10654-019-00568-5.

Article  PubMed  Google Scholar 

Booth GL, Kapral MK, Fung K, Tu JV. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet. 2006;368(9529):29–36. https://doi.org/10.1016/s0140-6736(06)68967-8.

Article  PubMed  Google Scholar 

Rao Kondapally Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–41. https://doi.org/10.1056/NEJMoa1008862.

Article  PubMed  PubMed Central  Google Scholar 

Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people. Lancet Diabetes Endocrinol. 2015;3(2):105–13. https://doi.org/10.1016/s2213-8587(14)70219-0.

Article  PubMed  PubMed Central  Google Scholar 

Huang ZT, Luo Y, Han L, Wang K, Yao SS, Su HX, et al. Patterns of cardiometabolic multimorbidity and the risk of depressive symptoms in a longitudinal cohort of middle-aged and older Chinese. J Affect Disord. 2022;301:1–7. https://doi.org/10.1016/j.jad.2022.01.030.

Article  PubMed  Google Scholar 

Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, et al. Association of Cardiometabolic Multimorbidity with Mortality. JAMA. 2015;314(1):52–60. https://doi.org/10.1001/jama.2015.7008.

Article  CAS  PubMed  Google Scholar 

Sattar N, Lee MMY, Kristensen SL, Branch KRH, Del Prato S, Khurmi NS, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021;9(10):653–62. https://doi.org/10.1016/s2213-8587(21)00203-5.

Article  CAS  PubMed  Google Scholar 

Ren J, Grundy SM, Liu J, Wang W, Wang M, Sun J, et al. Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese multi-provincial cohort study (CMCS). Atherosclerosis. 2010;211(1):327–32. https://doi.org/10.1016/j.atherosclerosis.2010.02.020.

Article  CAS  PubMed  Google Scholar 

Barkas F, Bathrellou E, Nomikos T, Panagiotakos D, Liberopoulos E, Kontogianni MD. Plant sterols and Plant Stanols in cholesterol management and Cardiovascular Prevention. Nutrients. 2023;15(13). https://doi.org/10.3390/nu15132845.

Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362–71. https://doi.org/10.1093/ajcn/79.3.362.

Article  CAS  PubMed  Google Scholar 

Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92(6):2017–29. https://doi.org/10.1210/jc.2007-0298.

Article  CAS  PubMed  Google Scholar 

Dibaba DT. Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis. Nutr Rev. 2019;77(12):890–902. https://doi.org/10.1093/nutrit/nuz037.

Article  PubMed  Google Scholar 

Mokhtari E, Hajhashemy Z, Saneei P. Serum Vitamin D Levels in relation to hypertension and pre-hypertension in adults: a systematic review and dose-response Meta-analysis of epidemiologic studies. Front Nutr. 2022. https://doi.org/10.3389/fnut.2022.829307.

Article  PubMed  PubMed Central  Google Scholar 

Mirhosseini N, Rainsbury J, Kimball SM, Vitamin D, Supplementation. Serum 25(OH)D concentrations and Cardiovascular Disease Risk factors: a systematic review and Meta-analysis. Front Cardiovasc Med. 2018;5:87. https://doi.org/10.3389/fcvm.2018.00087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hodge C, Taylor C, Vitamin A, Deficiency. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Christopher Taylor declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright © 2024. StatPearls Publishing LLC.; 2024.

Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, et al. Retinoids Repress Human Cardiovascular Cell Calcification with evidence for distinct selective Retinoid Modulator effects. Arterioscler Thromb Vasc Biol. 2020;40(3):656–69. https://doi.org/10.1161/atvbaha.119.313366.

Article  CAS  PubMed  Google Scholar 

Mu ZJ, Fu JL, Sun LN, Chan P, Xiu SL. Associations between homocysteine, inflammatory cytokines and Sarcopenia in Chinese older adults with type 2 diabetes. BMC Geriatr. 2021;21(1):692. https://doi.org/10.1186/s12877-021-02622-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Qin J, Liu W, Lv B, Yi N, Xue J, et al. Profiling of Homocysteine metabolic pathway related metabolites in plasma of Diabetic Mellitus based on LC-QTOF-MS. Molecules. 2023;28(2). https://doi.org/10.3390/molecules28020656.

Qi Z, Yang W, Xue B, Chen T, Lu X, Zhang R, et al. ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence. Autophagy. 2024;1–17. https://doi.org/10.1080/15548627.2024.2353548.

Liu W, Li Q, Wang Q, Ma S, Yang X, Zhang J, et al. Association between body fat composition and hyperhomocysteinemia in the analysis of the baseline data of the Northwest China Natural Population Cohort: Ningxia Project (CNC-NX). J Clin Hypertens (Greenwich). 2023;25(6):573–81. https://doi.org/10.1111/jch.14666.

Article  CAS  PubMed  Google Scholar 

Vidal-Petiot E. Thresholds for hypertension definition, treatment initiation, and treatment targets: recent guidelines at a glance. Circulation. 2022;146(11):805. https://doi.org/10.1161/circulationaha.121.055177.

Article  PubMed  Google Scholar 

Harreiter J, Roden M. [Diabetes mellitus: definition, classification, diagnosis, screening and prevention (update 2023)]. Wien Klin Wochenschr. 2023;135(Suppl 1):7–17. https://doi.org/10.1007/s00508-022-02122-y.

Article  PubMed  PubMed Central  Google Scholar 

Joseph JJ, Rajwani A, Roper D, Zhao S, Kline D, Odei J, et al. Associations of Cardiometabolic Multimorbidity with all-cause and Coronary Heart Disease Mortality among black adults in the Jackson Heart Study. JAMA Netw Open. 2022;5(10):e2238361. https://doi.org/10.1001/jamanetworkopen.2022.38361.

Article  PubMed  PubMed Central  Google Scholar 

Kivimäki M, Kuosma E, Ferrie JE, Luukkonen R, Nyberg ST, Alfredsson L, et al. Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe. Lancet Public Health. 2017;2(6):e277. https://doi.org/10.1016/s2468-2667(17)30074-9.

Article  PubMed  PubMed Central  Google Scholar 

Yu X, Zheng Y, Liu Y, Han P, Chen X, Zhang N, et al. Association of osteoporosis with Sarcopenia and its components among community-dwelling older Chinese adults with different obesity levels: a cross-sectional study. Med (Baltim). 2024;103(24):e38396. https://doi.org/10.1097/md.0000000000038396.

Article  CAS  Google Scholar 

Zhang J, Cheng Y, Chen C, Wang Q, Yang C, Qiu J, et al. Interaction of estradiol and vitamin D with low skeletal muscle mass among middle-aged and elderly women. BMC Womens Health. 2023;23(1):491. https://doi.org/10.1186/s12905-023-02646-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sewpaul R, Mbewu AD, Fagbamigbe AF, Kandala NB, Reddy SP. Prevalence of multimorbidity of cardiometabolic conditions and associated risk factors in a population-based sample of South africans: a cross-sectional study. Public Health Pract (Oxf). 2021. https://doi.org/10.1016/j.puhip.2021.100193.

Article  PubMed  Google Scholar 

Peer N, Balakrishna Y, de Villiers A, Naidoo P. Differential associations of cardio-metabolic diseases by population group, gender and adiposity in South Africa. PLoS ONE. 2018;13(9):e0202899. https://doi.org/10.1371/journal.pone.0202899.

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