Templeton SP, Perlman S. Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM. Immunol Res. 2007;39:160–72.
Article CAS PubMed PubMed Central Google Scholar
Hosking MP, Lane TE. The Biology of persistent infection: inflammation and demyelination following murine coronavirus infection of the Central Nervous System. Curr Immunol Rev. 2009;5:267–76.
Article CAS PubMed PubMed Central Google Scholar
Ireland DD, Stohlman SA, Hinton DR, Atkinson R, Bergmann CC. Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol. 2008;82:300–10.
Article CAS PubMed Google Scholar
Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol. 2004;172:4018–25.
Article CAS PubMed Google Scholar
Glass WG, Lane TE. Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8 + T cells following coronavirus infection of the central nervous system. Virology. 2003;312:407–14.
Article CAS PubMed Google Scholar
Glass WG, Lane TE. Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. J Virol. 2003;77:191–8.
Article CAS PubMed PubMed Central Google Scholar
Liu MT, Armstrong D, Hamilton TA, Lane TE. Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system. J Immunol. 2001;166:1790–5.
Article CAS PubMed Google Scholar
Liu MT, Chen BP, Oertel P, Buchmeier MJ, Armstrong D, Hamilton TA, Lane TE. The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J Immunol. 2000;165:2327–30.
Article CAS PubMed Google Scholar
Bergmann CC, Parra B, Hinton DR, Ramakrishna C, Dowdell KC, Stohlman SA. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol. 2004;78:1739–50.
Article CAS PubMed PubMed Central Google Scholar
Marten NW, Stohlman SA, Bergmann CC. MHV infection of the CNS: mechanisms of immune-mediated control. Viral Immunol. 2001;14:1–18.
Article CAS PubMed Google Scholar
Parra B, Hinton DR, Marten NW, Bergmann CC, Lin MT, Yang CS, Stohlman SA. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J Immunol. 1999;162:1641–7.
Article CAS PubMed Google Scholar
Phares TW, Marques CP, Stohlman SA, Hinton DR, Bergmann CC. Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol. 2011;85:2589–98.
Article CAS PubMed Google Scholar
Phares TW, Stohlman SA, Hinton DR, Bergmann CC. Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol. 2013;87:3382–92.
Article CAS PubMed PubMed Central Google Scholar
Bergmann CC, Lane TE, Stohlman SA. Coronavirus infection of the central nervous system: host-virus stand-off. Nat Rev Microbiol. 2006;4:121–32.
Article CAS PubMed PubMed Central Google Scholar
Hosking MP, Lane TE. The role of chemokines during viral infection of the CNS. PLoS Pathog. 2010;6(7):e1000937.
Article PubMed PubMed Central Google Scholar
Yin J, Valin KL, Dixon ML, Leavenworth JW. The role of Microglia and macrophages in CNS Homeostasis, autoimmunity, and Cancer. J Immunol Res. 2017;2017:5150678. https://doi.org/10.1155/2017/5150678.
Article CAS PubMed PubMed Central Google Scholar
Amor S, McNamara NB, Gerrits E, Marzin MC, Kooistra SM, Miron VE, Nutma E. White matter microglia heterogeneity in the CNS. Acta Neuropathol. 2022;143:125–41.
McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. Microglia regulate central nervous system myelin growth and integrity. Nature. 2023;613:120–9.
Article CAS PubMed Google Scholar
Butovsky O, Weiner HL. Microglial signatures and their role in health and disease. Nat Rev Neurosci. 2018;19:622–35.
Article CAS PubMed PubMed Central Google Scholar
Colonna M, Butovsky O. Microglia function in the Central Nervous System during Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–68.
Article CAS PubMed PubMed Central Google Scholar
Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci. 2014;15:300–12.
Article CAS PubMed Google Scholar
Priller J, Prinz M. Targeting microglia in brain disorders. Science. 2019;365:32–3.
Article CAS PubMed Google Scholar
Sanchez JMS, DePaula-Silva AB, Doty DJ, Hanak TJ, Truong A, Libbey JE, Fujinami RS. The CSF1R-Microglia Axis has protective host-specific roles during Neurotropic Picornavirus infection. Front Immunol. 2021;12:621090.
Article CAS PubMed PubMed Central Google Scholar
Sanchez JMS, DePaula-Silva AB, Doty DJ, Truong A, Libbey JE, Fujinami RS. Microglial cell depletion is fatal with low level picornavirus infection of the central nervous system. J Neurovirol. 2019;25:415–21.
Article CAS PubMed PubMed Central Google Scholar
Funk KE, Klein RS. CSF1R antagonism limits local restimulation of antiviral CD8(+) T cells during viral encephalitis. J Neuroinflammation. 2019;16(1):22. https://doi.org/10.1186/s12974-019-1397-4.
Article PubMed PubMed Central Google Scholar
Seitz S, Clarke P, Tyler KL. Pharmacologic depletion of Microglia increases viral load in the brain and enhances mortality in murine models of Flavivirus-Induced Encephalitis. J Virol. 2018;92(16):e00525–18. https://doi.org/10.1128/JVI.00525-18.
Article CAS PubMed PubMed Central Google Scholar
Wheeler DL, Sariol A, Meyerholz DK, Perlman S. Microglia are required for protection against lethal coronavirus encephalitis in mice. J Clin Invest. 2018;128:931–43.
Article PubMed PubMed Central Google Scholar
Sariol A, Mackin S, Allred MG, Ma C, Zhou Y, Zhang Q, Zou X, Abrahante JE, Meyerholz DK, Perlman S. Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection. Proc Natl Acad Sci U S A. 2020;117:24464–74.
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