CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

Diener HC, Hankey GJ (2020) Primary and secondary Prevention of ischemic Stroke and Cerebral Hemorrhage: JACC Focus Seminar. J Am Coll Cardiol 75(15):1804–1818

Article  PubMed  Google Scholar 

Dou Z, Yu Q, Wang G, Wu S, Reis C, Ruan W, Yan F, Chen G (2020) Circular RNA expression profiles alter significantly after intracerebral Hemorrhage in rats. Brain Res 1726:146490

Article  CAS  PubMed  Google Scholar 

Goldstein LB (2007) Acute ischemic Stroke treatment in 2007. Circulation 116(13):1504–1514

Article  PubMed  Google Scholar 

Lee H, Yun HJ, Ding Y (2021) Timing is everything: Exercise therapy and remote ischemic conditioning for acute ischemic Stroke patients. Brain Circ 7(3):178–186

Article  PubMed  PubMed Central  Google Scholar 

Mehta SL, Pandi G, Vemuganti R, Circular RNA (2017) Expression profiles alter significantly in mouse brain after transient focal ischemia. Stroke 48(9):2541–2548

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW, Jeyaseelan K (2009) Expression profile of MicroRNAs in young Stroke patients. PLoS ONE 4(11):e7689

Article  PubMed  PubMed Central  Google Scholar 

Wang XZ, Li S, Liu Y, Cui GY, Yan FL (2022) Construction of circRNA-Mediated Immune-related ceRNA Network and Identification of circulating circRNAs as diagnostic biomarkers in Acute ischemic Stroke. J Inflamm Res 15(17):4087–4104

Article  PubMed  PubMed Central  Google Scholar 

Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H (2018) Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic Stroke. Autophagy 14(7):1164–1184

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Si X, Ruan J, Ni Z, Li X, Sang H, Xia W, Huang J, Liu K, Lu S, Jiang L, Shao A, Yin C (2022) Circular RNA hsa_circ_0003574 as a biomarker for prediction and diagnosis of ischemic Stroke caused by intracranial atherosclerotic stenosis. Front Pharmacol 13(26):961866

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salzman J, Circular RNA, Expression (2016) Its potential regulation and function. Trends Genet 32(5):309–316

Article  CAS  PubMed  PubMed Central  Google Scholar 

Enuka Y, Lauriola M, Feldman ME, Sas-Chen A, Ulitsky I, Yarden Y (2016) Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res 44(3):1370–1383

Article  CAS  PubMed  Google Scholar 

Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC (2014) Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep 9(5):1966–1980

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei F, Zhang X, Kuang X, Gao X, Wang J, Fan J (2022) Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and its potential function in Atrial Fibrillation. Front Cardiovasc Med 9:883205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sandoval KE, Witt KA (2008) Blood-brain barrier tight junction permeability and ischemic Stroke. Neurobiol Dis 32(2):200–219

Article  CAS  PubMed  Google Scholar 

Zipser BD, Johanson CE, Gonzalez L, Berzin TM, Tavares R, Hulette CM, Vitek MP, Hovanesian V, Stopa EG (2007) Microvascular injury and blood-brain barrier leakage in Alzheimer’s Disease. Neurobiol Aging 28(7):977–986

Article  CAS  PubMed  Google Scholar 

Liu Y, Li Y, Zang J, Zhang T, Li Y, Tan Z, Ma D, Zhang T, Wang S, Zhang Y, Huang L, Wu Y, Su X, Weng Z, Deng D, Tsang CK, Xu A, Lu D (2022) CircOGDH is a Penumbra Biomarker and Therapeutic Target in Acute ischemic Stroke. Circ Res 130(6):907–924

Article  CAS  PubMed  Google Scholar 

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146(3):353–358

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Su X, Lv W, Yin L, Zhou ZYHA, Qi F (2019) CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. Aging 11(1):8183–8203

PubMed  Google Scholar 

Joaquim VHA, Pereira NP, Fernandes T, Oliveira EM (2023) Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases. Int J Mol Sci 24(3):2125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M (2022) Circular RNA ANAPC7 inhibits Tumor Growth and muscle wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer. Gastroenterology 162(7):2004–2017 e2

Article  CAS  PubMed  Google Scholar 

Song C, Zhang Y, Huang W, Shi J, Huang Q, Jiang M, Qiu Y, Wang T, Chen H, Wang H, Circular RNA (2022) Cwc27 contributes to Alzheimer’s Disease pathogenesis by repressing pur-alpha activity. Cell Death Differ 29(2):393–406

Article  CAS  PubMed  Google Scholar 

Wujun ML, Zhao S, Wang Z, Li Han Li 1, Shaoyi Li CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in Epilepsy, Neuropathol Appl Neurobiol 49(1) e12850

Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB (2016) Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res 44(6):2846–2858

Article  PubMed  PubMed Central  Google Scholar 

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S (2014) circRNA Biogenesis Competes with Pre-mRNA Splicing, Molecular Cell 56(1) 55–66

Wang Y, Wang Z (2015) Efficient backsplicing produces translatable circular mRNAs, RNA 21(2) 172-9

Chen C-K, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY (2021) Structured elements drive extensive circular RNA translation. Mol Cell 81(20):4300–4318e13

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, Wong CC, Xiao X, Wang Z (2017) 32 extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res 27(5):626–641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, Wong CC, Xiao X, Wang Z (2017) Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res 27(5):626–641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ergul A, Wolf V (2021) 34 Progress and challenges in preclinical Stroke recovery research, Brain Circulation 7(4)

Xiao Q, Hou R, Li H, Zhang S, Zhang F, Zhu X, Pan X (2021) Circulating exosomal circRNAs contribute to potential diagnostic value of large artery atherosclerotic Stroke. Front Immunol 12:830018

Article  CAS  PubMed  Google Scholar 

Li S, Hu W, Deng F, Chen S, Zhu P, Wang M, Chen X, Wang Y, Hu X, Zhao B, Zhong W, Ma G, Li Y (2021) Identification of circular RNA hsa_circ_0001599 as a Novel Biomarker for large-artery atherosclerotic Stroke. DNA Cell Biol 40(3):457–468

Article  CAS  PubMed  Google Scholar 

Liu W, Jia C, Luo L, Wang HL, Min XL, Xu JH, Ma LQ, Yang XM, Wang YW, Shang FF (2019) Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. Neural Regen Res 14(12):2104–2111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Z, Hu Q, Guo H, Wang X (2023) CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs), Clinical hemorheology and microcirculation

Jiang S, Zhao G, Lu J, Jiang M, Wu Z, Huang Y, Huang J, Shi J, Jin J, Xu X, Pu X (2020) Silencing of circular RNA ANRIL attenuates oxygen-glucose deprivation and reoxygenation-induced injury in human brain microvascular endothelial cells by sponging miR-622. Biol Res 53(1):27

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, Zang J, Weng Z, Lu D, Tsang CK, Li K, Xu A (2022) Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. Mol Ther 30(3):1275–1287

Article  CAS  PubMed  Google Scholar 

Liu Z, Wu X, Yu Z, Tang X (2021) Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral Hemorrhage. Sci Rep 11(1):11584

Article  CAS  PubMed  PubMed Central  Google Scholar 

An SJ, Kim TJ, Yoon BW (2017) Epidemiology, risk factors, and clinical features of Intracerebral Hemorrhage: an update. J Stroke 19(1):3–10

Article  PubMed  PubMed Central  Google Scholar 

Cao H, Chen J, Lai X, Liu T, Qiu P, Que S, Huang Y (2021) Circular RNA expression profile in human primary multiple intracranial Aneurysm. Exp Ther Med 21(3):239

Comments (0)

No login
gif