Breijyeh Z, Karaman R. Comprehensive review on Alzheimer’s disease: causes and treatment. Molecules. 2020;25:5789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fakhoury M. Microglia and astrocytes in Alzheimer’s disease: implications for therapy. Curr Neuropharmacol. 2018;16:508–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hansen DV, Hanson JE, Sheng M. Microglia in Alzheimer’s disease. J Cell Biol. 2018;217:459–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s disease. Am J Pathol. 2001;158:1345–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ries M, Sastre M. Mechanisms of Aβ clearance and degradation by glial cells. Front Aging Neurosci. 2016. https://doi.org/10.3389/fnagi.2016.00160.

Article  PubMed  PubMed Central  Google Scholar 

Solito E, Sastre M. Microglia function in Alzheimer’s disease. Front Pharmacol. 2012. https://doi.org/10.3389/fphar.2012.00014.

Article  PubMed  PubMed Central  Google Scholar 

Lee CYD, Landreth GE. The role of microglia in amyloid clearance from the AD brain. J Neural Transm. 2010;117:949–60.

Article  CAS  PubMed  Google Scholar 

Rodríguez JJ, Olabarria M, Chvatal A, Verkhratsky A. Astroglia in dementia and Alzheimer’s disease. Cell Death Differ. 2009;16:378–85.

Article  PubMed  Google Scholar 

Mendiola-Precoma J, Berumen LC, Padilla K, Garcia-Alcocer G. Therapies for prevention and treatment of Alzheimer’s disease. Biomed Res Int. 2016;2016:1–17.

Article  Google Scholar 

Vaz M, Silvestre S. Alzheimer’s disease: recent treatment strategies. Eur J Pharmacol. 2020;887:173554.

Article  CAS  PubMed  Google Scholar 

Sanders LMJ, Hortobágyi T, la Bastide-van GS, van der Zee EA, van Heuvelen MJG. Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: a systematic review and meta-analysis. PLoS ONE. 2019;14:e0210036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jahangiri Z, Gholamnezhad Z, Hosseini M. Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer’s. Metab Brain Dis. 2019;34:21–37.

Article  CAS  PubMed  Google Scholar 

De la Rosa A, Olaso-Gonzalez G, Arc-Chagnaud C, Millan F, Salvador-Pascual A, García-Lucerga C, et al. Physical exercise in the prevention and treatment of Alzheimer’s disease. J Sport Heal Sci. 2020;9:394–404.

Article  Google Scholar 

Rodríguez-Giraldo M, González-Reyes RE, Ramírez-Guerrero S, Bonilla-Trilleras CE, Guardo-Maya S, Nava-Mesa MO. Astrocytes as a therapeutic target in alzheimer’s disease–comprehensive review and recent developments. Int J Mol Sci. 2022;23:13630.

Article  PubMed  PubMed Central  Google Scholar 

Runge M, Rehfeld G, Resnicek E. Balance training and exercise in geriatric patients. J Musculoskelet Neuronal Interact. 2000;1:61–5.

CAS  PubMed  Google Scholar 

Zhang L, Weng C, Liu M, Wang Q, Liu L, He Y. Effect of whole-body vibration exercise on mobility, balance ability and general health status in frail elderly patients: a pilot randomized controlled trial. Clin Rehabil. 2014;28:59–68.

Article  CAS  PubMed  Google Scholar 

Mettlach G, Polo-Parada L, Peca L, Rubin CT, Plattner F, Bibb JA. Enhancement of neuromuscular dynamics and strength behavior using extremely low magnitude mechanical signals in mice. J Biomech. 2014;47:162–7.

Article  PubMed  Google Scholar 

Patel VS, Chan ME, Pagnotti GM, Frechette DM, Rubin J, Rubin CT. Incorporating refractory period in mechanical stimulation mitigates obesity-induced adipose tissue dysfunction in adult mice. Obesity. 2017;25:1745–53.

Article  CAS  PubMed  Google Scholar 

Corbiere T, Weinheimer-Haus E, Judex S, Koh T. Low-intensity vibration improves muscle healing in a mouse model of laceration injury. J Funct Morphol Kinesiol. 2017;3:1.

Article  PubMed  Google Scholar 

Cariati I, Bonanni R, Pallone G, Annino G, Tancredi V, D’Arcangelo G. Modulation of synaptic plasticity by vibratory training in young and old mice. Brain Sci. 2021;11:82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng G, Yang L, Wu CY, Zhang LL, Wu CY, Li F, et al. Whole body vibration training improves depression-like behaviors in a rat chronic restraint stress model. Neurochem Int. 2021;142:104926.

Article  CAS  PubMed  Google Scholar 

Oroszi T, Geerts E, de Boer SF, Schoemaker RG, van der Zee EA, Nyakas C. Whole body vibration improves spatial memory, anxiety-like behavior, and motor performance in aged male and female rats. Front Aging Neurosci. 2022. https://doi.org/10.3389/fnagi.2021.801828.

Article  PubMed  PubMed Central  Google Scholar 

Oroszi T, de Boer SF, Nyakas C, Schoemaker RG, van der Zee EA. Chronic whole body vibration ameliorates hippocampal neuroinflammation, anxiety-like behavior, memory functions and motor performance in aged male rats dose dependently. Sci Rep. 2022;12:9020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang D, Yang Z, Wang Z, Wang P, Qu Y. The macroscopic and microscopic effect of low-frequency whole-body vibration after cerebral ischemia in rats. Metab Brain Dis. 2018;33:15–25.

Article  PubMed  Google Scholar 

Raval A, Schatz M, Bhattacharya P, d’Adesky N, Rundek T, Dietrich W, et al. Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats. Int J Mol Sci. 2018;19:2749.

Article  PubMed  PubMed Central  Google Scholar 

Monteiro F, Sotiropoulos I, Carvalho Ó, Sousa N, Silva FS. Multi-mechanical waves against Alzheimer’s disease pathology: a systematic review. Transl Neurodegener. 2021;10:36.

Article  PubMed  PubMed Central  Google Scholar 

Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, et al. High-level neuronal expression of Aβ 1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000;20:4050–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu G-Q, et al. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer’s disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci. 2010;30:372–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, et al. ABAD Directly links Aß to mitochondrial toxicity in Alzheimer’s disease. Science. 2004;304:448–52.

Article  CAS  PubMed  Google Scholar 

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, et al. Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem. 2007;282:23818–28.

Article  CAS  PubMed  Google Scholar 

Lalonde R, Kim HD, Fukuchi K. Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice. Neurosci Lett. 2004;369:156–61.

Article  CAS  PubMed  Google Scholar 

Wright AL, Zinn R, Hohensinn B, Konen LM, Beynon SB, Tan RP, et al. Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer’s disease. PLoS ONE. 2013;8:e59586.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Heuvelen MJG, Rittweger J, Judex S, Sañudo B, Seixas A, Fuermaier ABM, et al. Reporting guidelines for whole-body vibration studies in humans, animals and cell cultures: a consensus statement from an international group of experts. Biology. 2021;10:965.

Article  PubMed  PubMed Central  Google Scholar 

Keijser JN, Marieke JG, van Heuvelen MJG, Nyakas C, Toth K, Schoemaker RG, et al. Whole body vibration improves attention and motor performance in mice depending on the duration of the whole body vibration session. African J Tradit Complement Altern Med. 2017;14:128–34.

Article  Google Scholar 

Boerema AS, Heesterbeek M, Boersma SA, Schoemaker R, de Vries EFJ, van Heuvelen MJG, et al. Beneficial effects of whole body vibration on brain functions in mice and humans. Dose Response. 2018;16:155932581881175.

Article  Google Scholar 

Hovens I, Nyakas C, Schoemaker R. A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio. Neuroimmunol Neuroinflamm. 2014;1:82.

Article