Risk-adapted venous thromboembolism prophylaxis in Asian patients admitted to medical intensive care unit: a prospective controlled trial

Arunothai S, Sutherasan Y, Panpikoon T, Theerawit P, Angchaisuksiri P, Boonyawat K. Low incidence of deep vein thrombosis in critically ill medical patients in Thais: a prospective study. Res Pract Thromb Haemost. 2024;8(5):102522.

Article  PubMed  PubMed Central  Google Scholar 

Boonyawat K, Crowther MA. Venous thromboembolism prophylaxis in critically ill patients. Semin Thromb Hemost. 2015;41(1):68–74.

Article  PubMed  Google Scholar 

Cook D, Crowther M, Meade M, Rabbat C, Griffith L, Schiff D, et al. Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med. 2005;33(7):1565–71.

Article  PubMed  Google Scholar 

Lee LH, Gallus A, Jindal R, Wang C, Wu CC. Incidence of venous thromboembolism in Asian populations: a systematic review. Thromb Haemost. 2017;117(12):2243–60.

Article  PubMed  Google Scholar 

Sahle BW, Pilcher D, Peter K, McFadyen JD, Litton E, Bucknall T. Mortality data from omission of early thromboprophylaxis in critically ill patients highlights the importance of an individualised diagnosis-related approach. Thromb J. 2023;21(1):59.

Article  PubMed  PubMed Central  Google Scholar 

Cook D, Meade M, Guyatt G, Walter S, Heels-Ansdell D, Warkentin TE, Zytaruk N, Crowther M, Geerts W, Cooper DJ, et al. Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med. 2011;364(14):1305–14.

Article  CAS  PubMed  Google Scholar 

Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, et al. VTE prophylaxis in critically ill adults: A systematic review and network Meta-analysis. Chest. 2022;161(2):418–28.

Article  CAS  PubMed  Google Scholar 

Schünemann HJ, Cushman M, Burnett AE, Kahn SR, Beyer-Westendorf J, Spencer FA, et al. American society of hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients. Blood Adv. 2018;2(22):3198–225.

Article  PubMed  PubMed Central  Google Scholar 

Brighton Timothy A, Eikelboom John W, Mann K, Mister R, Gallus A, Ockelford P, et al. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med. 2012;367(21):1979–87.

Article  CAS  PubMed  Google Scholar 

Becattini C, Agnelli G, Schenone A, Eichinger S, Bucherini E, Silingardi M, et al. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med. 2012;366(21):1959–67.

Article  CAS  PubMed  Google Scholar 

Gupta E, Siddiqi FS, Kunjal R, Faisal M, Al-Saffar F, Bajwa AA, et al. Association between aspirin use and deep venous thrombosis in mechanically ventilated ICU patients. J Thromb Thrombolysis. 2017;44(3):330–4.

Article  CAS  PubMed  Google Scholar 

Cohen Alexander T, Spiro Theodore E, Büller Harry R, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos Alex C, et al. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med. 2013;368(6):513–23.

Goldhaber Samuel Z, Leizorovicz A, Kakkar Ajay K, Haas Sylvia K, Merli G, Knabb Robert M, et al. Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients. N Engl J Med. 2011;365(23):2167–77.

Article  CAS  PubMed  Google Scholar 

Trkulja V. Safety of Apixaban for venous thromboembolism prophylaxis: the evidence to date. Drug Healthc Patient Saf. 2016;8:25–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Permpikul C, Chaiyasoot W, Panitchote A. Incidence of proximal deep vein thrombosis in medical critical care patients. Thromb J. 2022;20(1):5.

Article  PubMed  PubMed Central  Google Scholar 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sevransky J. Clinical assessment of hemodynamically unstable patients. Curr Opin Crit Care. 2009;15(3):234–8.

PubMed  PubMed Central  Google Scholar 

Zhou H, Hu Y, Li X, Wang L, Wang M, Xiao J, et al. Assessment of the risk of venous thromboembolism in medical inpatients using the Padua prediction score and Caprini risk assessment model. J Atheroscler Thromb. 2018;25(11):1091–104.

Article  PubMed  PubMed Central  Google Scholar 

Kooiman J, van Hagen N, Del Iglesias A, Planken EV, Lip GY, van der Meer FJ, Cannegieter SC, Klok FA, Huisman MV. The HAS-BLED score identifies patients with acute venous thromboembolism at high risk of major bleeding complications during the first six months of anticoagulant treatment. PLoS ONE. 2015;10(4):e0122520.

Article  PubMed  PubMed Central  Google Scholar 

Anderson DR, Morgano GP, Bennett C, Dentali F, Francis CW, Garcia DA, et al. American society of hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv. 2019;3(23):3898–944.

Article  PubMed  PubMed Central  Google Scholar 

Mumtaz H, Ejaz MK, Tayyab M, Vohra LI, Sapkota S, Hasan M, et al. Apache scoring as an indicator of mortality rate in ICU patients: a cohort study. Ann Med Surg. 2023;85(3):416–21.

Article  Google Scholar 

Kaatz S, Ahmad D, Spyropoulos AC, Schulman S. Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH. J Thromb Haemost. 2015;13(11):2119–26.

Article  CAS  PubMed  Google Scholar 

Ng TMH, Tsai F, Khatri N, Barakat MN, Elkayam U. Venous thromboembolism in hospitalized patients with heart failure. Circulation: Heart Failure. 2010;3(1):165–73.

PubMed  Google Scholar 

Kaplan D, Casper TC, Elliott CG, Men S, Pendleton RC, Kraiss LW, et al. VTE incidence and risk factors in patients with severe sepsis and septic shock. Chest. 2015;148(5):1224–30.

Article  PubMed  PubMed Central  Google Scholar 

Minet C, Potton L, Bonadona A, Hamidfar-Roy R, Somohano CA, Lugosi M, et al. Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis. Crit Care. 2015;19(1):287.

Article  PubMed  PubMed Central  Google Scholar 

Fraisse F, Holzapfel L, Couland JM, Simonneau G, Bedock B, Feissel M, et al. Nadroparin in the prevention of deep vein thrombosis in acute decompensated COPD. The association of non-university affiliated intensive care specialist physicians of France. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1109–14.

Article  CAS  PubMed  Google Scholar 

Ho KM, Chavan S, Pilcher D. Omission of early thromboprophylaxis and mortality in critically ill patients: a multicenter registry study. Chest. 2011;140(6):1436–46.

Article  PubMed  Google Scholar 

Lilly CM, Liu X, Badawi O, Franey CS, Zuckerman IH. Thrombosis prophylaxis and mortality risk among critically ill adults. Chest. 2014;146(1):51–7.

Article  PubMed  Google Scholar 

Raskob GE, Spyropoulos AC, Cohen AT, Weitz JI, Ageno W, De Sanctis Y, et al. Association between asymptomatic proximal deep vein thrombosis and mortality in acutely ill medical patients. J Am Heart Assoc. 2021;10(5):e019459.

Article  PubMed  PubMed Central  Google Scholar 

Lapébie FX, Minville V, Ribes A, Combis B, Thery A, Geeraerts T, Silva S, Bura-Rivière A, Vardon-Bounes F. Systematic screening for deep vein thrombosis in critically ill inpatients with COVID-19: impact on the incidence of venous thromboembolism. Front Med (Lausanne). 2020;7:624808.

Article  PubMed  Google Scholar 

Hull RD, Merali T, Mills A, Stevenson AL, Liang J. Venous thromboembolism in elderly high-risk medical patients: time course of events and influence of risk factors. Clin Appl Thromb Hemost. 2013;19(4):357–62.

Article  PubMed  Google Scholar 

Wang M, Wang W, Jia X, He Q, Zhu S, Kang Y, et al. Associations between antithrombosis and ventilator-associated events, ICU stays, and mortality among mechanically ventilated patients: a registry-based cohort study. Front Pharmacol. 2022.

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