Kim AS, Khorana AA, McCrae KR. Mechanisms and biomarkers of cancer-associated thrombosis. Translational Res. 2020;225:33–53.

Article  CAS  Google Scholar 

Zhao H, Liang F, Ling Y, Li T, Fang B, Deng T et al. Prevalence and treatment of venous thromboembolism in patients with solid tumors. Exp Ther Med. 2022;24(6).

Mosaad M, Elnaem MH, Cheema E, Ibrahim I, Ab Rahman J, Kori AN, et al. Cancer-Associated thrombosis: A clinical scoping review of the risk assessment models across solid tumours and haematological malignancies. Int J Gen Med. 2021;14:3881.

Article  PubMed  PubMed Central  Google Scholar 

Walker AJ, Card TR, West J, Crooks C, Grainge MJ. Incidence of venous thromboembolism in patients with cancer-A cohort study using linked united Kingdom databases. Eur J Cancer. 2013;49(6):1404–13.

Article  PubMed  Google Scholar 

Yu Y, Bin, Gau JP, Liu CY, Yang MH, Chiang SC, Hsu HC et al. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 2012;108(2).

Königsbrügge O, Pabinger I, Ay C. Risk factors for venous thromboembolism in cancer: novel findings from the Vienna Cancer and thrombosis study (CATS). Thromb Res. 2014;133 Suppl 2(SUPPL. 2).

Ohashi Y, Ikeda M, Kunitoh H, Sasako M, Okusaka T, Mukai H, et al. Venous thromboembolism in cancer patients: report of baseline data from the multicentre, prospective Cancer-VTE registry. Jpn J Clin Oncol. 2021;50(11):1246–53.

Article  Google Scholar 

Franchini M, Tufano A, Casoria A, Coppola A. Arterial thrombosis in Cancer patients: an update. Semin Thromb Hemost. 2021;47(8):942–9.

Article  CAS  PubMed  Google Scholar 

Costa J, Araújo A. Cancer-Related venous thromboembolism: from pathogenesis to risk assessment. Semin Thromb Hemost. 2021;47(6):669–76.

Article  CAS  PubMed  Google Scholar 

Bolek H, Ürün Y. Cancer-associated thrombosis and drug–drug interactions of antithrombotic and antineoplastic agents. Cancer. 2023;129(20):3216–29.

Article  CAS  PubMed  Google Scholar 

Jones C, Menchaca K, Ostos C, Durbin J, Chen K, Peles S. Outcomes of thromboembolism in COVID-19 Cancer patients vs Non-Cancer patients. Blood. 2022;140(Supplement 1):5660.

Article  Google Scholar 

Didier AJ, Campbell A, Nandwani S, Fahoury A, Arsene C. In-hospital mortality patterns and risk factors in patients with cancer with COVID-19. 42(16_suppl):e23070-e23070.

Khorana A, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008;111(10):4902–7

Mulder FI, Candeloro M, Kamphuisen PW, Di Nisio M, Bossuyt PM, Guman N, et al. The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis. Haematologica. 2019;104(6):1277–87.

Article  PubMed  PubMed Central  Google Scholar 

Verso M, Agnelli G, Barni S, Gasparini G, LaBianca R. A modified Khorana risk assessment score for venous thromboembolism in cancer patients receiving chemotherapy: the protecht score. Intern Emerg Med. 2012:291–2.

Pelzer U, Sinn M, Stieler J, Riess H. [Primary Pharmacological prevention of thromboembolic events in ambulatory patients with advanced pancreatic cancer treated with chemotherapy?]. Dtsch Med Wochenschr. 2013;138(41):2084–8.

CAS  PubMed  Google Scholar 

Frere C, Farge D, Schrag D, Prata PH, Connors JM. Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials. J Hematol Oncol. 2022;15(1):1–6.

Article  Google Scholar 

Riaz I, Bin, Fuentes H, Deng Y, Naqvi SAA, Yao X, Sangaralingham LR, et al. Comparative effectiveness of anticoagulants in patients with Cancer-Associated thrombosis. JAMA Netw Open. 2023;6(7):e2325283.

Article  PubMed  PubMed Central  Google Scholar 

Schrag D, Uno H, Rosovsky R, Rutherford C, Sanfilippo K, Villano JL, et al. Direct oral anticoagulants vs Low-Molecular-Weight heparin and recurrent VTE in patients with cancer: A randomized clinical trial. JAMA. 2023;329(22):1924–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khorana AA, Noble S, Lee AYY, Soff G, Meyer G, O’Connell C, et al. Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: guidance from the SSC of the ISTH. J Thromb Haemost. 2018;16(9):1891–4.

Article  CAS  PubMed  Google Scholar 

Dentali F, Pegoraro S, Barco S, di Minno MND, Mastroiacovo D, Pomero F, et al. Clinical course of isolated distal deep vein thrombosis in patients with active cancer: a multicenter cohort study. J Thromb Haemost. 2017;15(9):1757–63.

Article  CAS  PubMed  Google Scholar 

CPG. ‘Management of Obesity’ - Malaysia Endocrine & Metabolic Society. [cited 2025 Feb 11]. Available from: https://mems.my/cpg-management-of-obesity/

Lee LH, Nagarajan C, Tan CW, Ng HJ. Epidemiology of Cancer-Associated thrombosis in Asia: A systematic review. Front Cardiovasc Med. 2021;8:669288.

Article  PubMed  PubMed Central  Google Scholar 

Weitz JI, Haas S, Ageno W, Goldhaber SZ, Turpie AGG, Goto S, et al. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE. J Thromb Thrombolysis. 2020;50(2):267–77.

Article  CAS  PubMed  Google Scholar 

Moik F, Colling M, Mahé I, Jara-Palomares L, Pabinger I, Ay C. Extended anticoagulation treatment for cancer-associated thrombosis-Rates of recurrence and bleeding beyond 6 months: A systematic review. J Thromb Haemost. 2022;20(3):619–34.

Article  PubMed  Google Scholar 

Ikeda M, Uetake H, Yoshino T, Hata T, Oba MS, Takita A, et al. Incidence and risk factors for venous thromboembolism, bleeding, and death in colorectal cancer (Cancer-VTE Registry). Cancer Sci. 2022;113(11):3901–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Winter PC. The pathogenesis of venous thromboembolism in cancer: emerging links with tumour biology. Hematol Oncol. 2006;24(3):126–33.

Article  CAS  PubMed  Google Scholar 

Tuzovic M, Herrmann J, Iliescu C, Marmagkiolis K, Ziaeian B, Yang EH. Arterial thrombosis in patients with Cancer. Curr Treat Options Cardiovasc Med. 2018;20(5).

Simanek R, Vormittag R, Ay C, Alguel G, Dunkler D, Schwarzinger I, et al. High platelet count associated with venous thromboembolism in cancer patients: results from the Vienna Cancer and thrombosis study (CATS). J Thromb Haemost. 2010;8(1):114–20.

Article  CAS  PubMed  Google Scholar 

Chong CT, Lai WK, Sallehuddin SM, Ganapathy SS. Prevalence of overweight and its associated factors among Malaysian adults: findings from a nationally representative survey. PLoS ONE. 2023;18(8).

Kwaifa IK, Bahari H, Yong YK, Md Noor S. Endothelial dysfunction in Obesity-Induced inflammation: molecular mechanisms and clinical implications. Biomolecules. 2020;10(2).

Hotoleanu C. Association between obesity and venous thromboembolism. Med Pharm Rep. 2020;93(2):162–8.

PubMed  PubMed Central  Google Scholar 

Peng M, Yang S, Li G, Zhang T, Qin X, Shi C, et al. Solid tumor complicated with venous thromboembolism: A 10-Year retrospective Cross-Sectional study. Clin Appl Thromb Hemost. 2021;27:1076029620975484.

Alcalay A, Wun T, Khatri V, Chew HK, Harvey D, Zhou H, et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival. J Clin Oncol. 2006;24(7):1112–8.

Article  PubMed  Google Scholar 

Chew HK, Wun T, Harvey DJ, Zhou H, White RH. Incidence of venous thromboembolism and the impact on survival in breast cancer patients. J Clin Oncol. 2007;25(1):70–6.

Article  PubMed  Google Scholar 

Ashrani AA, Gullerud RE, Petterson TM, Marks RS, Bailey KR, Heit JA. Risk factors for incident venous thromboembolism in active Cancer patients: A population based Case-Control study. Thromb Res. 2016;139:29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Falanga A, Russo L, Milesi V, Vignoli A. Mechanisms and risk factors of thrombosis in cancer. Crit Rev Oncol Hematol. 2017;118:79–83.

Article  PubMed  Google Scholar 

van Es N, Hisada Y, Di Nisio M, Cesarman G, Kleinjan A, Mahé I, et al. Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: A prospective cohort study. Thromb Res. 2018;166:54–9.

Article  PubMed  Google Scholar 

Ibrahim MB, Litvin R, Noor H, Khan AH, Ishaya M, Obeidat K, et al. COVID-19 and prevalence of venous thromboembolism among cancer patients: A nationwide inpatient sample analysis. J Clin Oncol. 2023;41(16_suppl):e18839–18839.

Article  Google Scholar 

López-Jiménez C, Gutiérrez A, Juliao Caamaño DS, Soto Alsar J, Catoya Villa JL, Blanco Abad C, et al. Impact of COVID-19 in the incidence of venous thromboembolism (VTE) and clinical outcomes in cancer patients: a cohort study. Clin Transl Oncol. 2025;27(2):756–69.

Article  PubMed  Google Scholar 

Akasaka-Kihara F, Sueta D, Ishii M, Maki Y, Hirakawa K, Tabata N, et al. Validation of the Khorana venous thromboembolism risk score in Japanese Cancer patients. JACC Asia. 2021;1(2):259–70.

Article  PubMed  PubMed Central  Google Scholar 

Ha H, Ko YH, Kim K, Hong J, Lee GW, Jeong SH et al. Application of t