Abbott RD, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD, Grandinetti A, Blanchette PL, Popper JS, Ross GW (2001) Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology 57(3):456–462. https://doi.org/10.1212/wnl.57.3.456

Article  PubMed  CAS  Google Scholar 

Abdill RJ, Graham SP, Rubinetti V, Ahmadian M, Hicks P, Chetty A, McDonald D, Ferretti P, Gibbons E, Rossi M, Krishnan A, Albert FW, Greene CS, Davis S, Blekhman R (2025) Integration of 168,000 samples reveals global patterns of the human gut microbiome. Cell 188(4):1100–1118. https://doi.org/10.1016/j.cell.2024.12.017

Article  PubMed  CAS  Google Scholar 

Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Dore J, Meta HITC, Antolin M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Merieux A, Melo Minardi R, M’Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P (2011) Enterotypes of the human gut microbiome. Nature 473(7346):174–180. https://doi.org/10.1038/nature09944

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F, Bork P, Wullner U (2017) Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson’s disease patients. Genome Med 9(1):39. https://doi.org/10.1186/s13073-017-0428-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen SJ, Chen CC, Liao HY, Wu YW, Liou JM, Wu MS, Kuo CH, Lin CH (2022) Alteration of gut microbial metabolites in the systemic circulation of patients with Parkinson’s disease. J Parkinsons Dis. https://doi.org/10.3233/JPD-223179

Article  PubMed  PubMed Central  Google Scholar 

Itan Y, Jones BL, Ingram CJ, Swallow DM, Thomas MG (2010) A worldwide correlation of lactase persistence phenotype and genotypes. BMC Evol Biol 10:36. https://doi.org/10.1186/1471-2148-10-36

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jo S, Kang W, Hwang YS, Lee SH, Park KW, Kim MS, Lee H, Yoon HJ, Park YK, Chalita M, Lee JH, Sung H, Lee JY, Bae JW, Chung SJ (2022) Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease. NPJ Parkinsons Dis 8(1):87. https://doi.org/10.1038/s41531-022-00351-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kono K, Murakami Y, Ebara A, Okuma K, Tokuno H, Odachi A, Ogasawara K, Hidaka E, Mori T, Satoh K, Kimoto S, Masuyama H, Takeda M, Managi S (2022) Fluctuations in intestinal microbiota following ingestion of natto powder containing Bacillus subtilis var. natto SONOMONO spores: considerations using a large-scale intestinal microflora database. Nutrients. https://doi.org/10.3390/nu14183839

Article  PubMed  PubMed Central  Google Scholar 

Liu WM, Wu RM, Lin JW, Liu YC, Chang CH, Lin CH (2016) Time trends in the prevalence and incidence of Parkinson’s disease in Taiwan: a nationwide, population-based study. J Formos Med Assoc 115(7):531–538. https://doi.org/10.1016/j.jfma.2015.05.014

Article  PubMed  Google Scholar 

Maeda T, Shimo Y, Chiu SW, Yamaguchi T, Kashihara K, Tsuboi Y, Nomoto M, Hattori N, Watanabe H, Saiki H, JF (2017) Clinical manifestations of nonmotor symptoms in 1021 Japanese Parkinson’s disease patients from 35 medical centers. Parkinsonism Relat Disord 38:54–60. https://doi.org/10.1016/j.parkreldis.2017.02.024

Article  PubMed  Google Scholar 

Mao L, Zhang Y, Tian J, Sang M, Zhang G, Zhou Y, Wang P (2021) Cross-sectional study on the gut microbiome of Parkinson’s disease patients in central China. Front Microbiol 12:728479. https://doi.org/10.3389/fmicb.2021.728479

Article  PubMed  PubMed Central  Google Scholar 

Nishijima S, Suda W, Oshima K, Kim SW, Hirose Y, Morita H, Hattori M (2016) The gut microbiome of healthy Japanese and its microbial and functional uniqueness. DNA Res 23(2):125–133. https://doi.org/10.1093/dnares/dsw002

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nishiwaki H, Ito M, Ishida T, Hamaguchi T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K (2020) Meta-analysis of gut dysbiosis in Parkinson’s disease. Mov Disord 35(9):1626–1635. https://doi.org/10.1002/mds.28119

Article  PubMed  CAS  Google Scholar 

Nishiwaki H, Ito M, Hamaguchi T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Yoshida T, Hanada H, Takeuchi I, Katsuno M, Hirayama M, Ohno K (2022) Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease. NPJ Parkinsons Dis 8(1):65. https://doi.org/10.1038/s41531-022-00328-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nishiwaki H, Ueyama J, Ito M, Hamaguchi T, Takimoto K, Maeda T, Kashihara K, Tsuboi Y, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K (2024) Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease. NPJ Parkinsons Dis 10(1):106. https://doi.org/10.1038/s41531-024-00724-z

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pringsheim T, Jette N, Frolkis A, Steeves TD (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29(13):1583–1590. https://doi.org/10.1002/mds.25945

Article  PubMed  Google Scholar 

Qian Y, Yang X, Xu S, Huang P, Li B, Du J, He Y, Su B, Xu LM, Wang L, Huang R, Chen S, Xiao Q (2020) Gut metagenomics-derived genes as potential biomarkers of Parkinson’s disease. Brain 143(8):2474–2489. https://doi.org/10.1093/brain/awaa201

Article  PubMed  Google Scholar 

Ueyama J, Oda M, Hirayama M, Sugitate K, Sakui N, Hamada R, Ito M, Saito I, Ohno K (2020) Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids. Anal Biochem 589:113508. https://doi.org/10.1016/j.ab.2019.113508

Article  PubMed  CAS  Google Scholar 

Wallen ZD, Demirkan A, Twa G, Cohen G, Dean MN, Standaert DG, Sampson TR, Payami H (2022) Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms. Nat Commun 13(1):6958. https://doi.org/10.1038/s41467-022-34667-x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xiong X, Zhai S (2016) Rapid and simultaneous quantification of polyamines in human plasma by LC–MS/MS after pre-column derivatization with N-(9-fluorenylmethoxycarbonyloxy)succinimide. Chromatographia 79(9–10):561–570. https://doi.org/10.1007/s10337-016-3079-z

Article  CAS  Google Scholar 

Yamawaki M, Kusumi M, Kowa H, Nakashima K (2009) Changes in prevalence and incidence of Parkinson’s disease in Japan during a quarter of a century. Neuroepidemiology 32(4):263–269. https://doi.org/10.1159/000201565

Article  PubMed  Google Scholar 

Yin W, Lof M, Pedersen NL, Sandin S, Fang F (2021) Mediterranean dietary pattern at middle age and risk of Parkinson’s disease: a Swedish cohort study. Mov Disord 36(1):255–260. https://doi.org/10.1002/mds.28314

Article  PubMed  Google Scholar 

Zhu J, Cui Y, Zhang J, Yan R, Su D, Zhao D, Wang A, Feng T (2024) Temporal trends in the prevalence of Parkinson’s disease from 1980 to 2023: a systematic review and meta-analysis. Lancet Healthy Longev 5(7):e464–e479. https://doi.org/10.1016/S2666-7568(24)00094-1

Article  PubMed  Google Scholar