Retrospective cohort study and meta-analysis of individualized luteal phase support with additional oral dydrogesterone in artificially prepared frozen embryo transfer cycles

Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998;13:1968–74.

Article  CAS  PubMed  Google Scholar 

Druckmann R, Druckmann M-A. Progesterone and the immunology of pregnancy. J Steroid Biochem Mol Biol. 2005;97:389–96.

Article  CAS  PubMed  Google Scholar 

Yovich JL, Conceicao JL, Stanger JD, Hinchliffe PM, Keane KN. Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement. Reprod Biomed Online. 2015;31:180–91.

Article  CAS  PubMed  Google Scholar 

Cédrin-Durnerin I, Isnard T, Mahdjoub S, Sonigo C, Seroka A, Comtet M, et al. Serum progesterone concentration and live birth rate in frozen–thawed embryo transfers with hormonally prepared endometrium. Reprod Biomed Online. 2019;38:472–80.

Article  PubMed  Google Scholar 

Alsbjerg B, Thomsen L, Elbaek HO, Laursen R, Povlsen BB, Haahr T, et al. Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes. Reprod Biomed Online. 2018;37:641–7.

Article  CAS  PubMed  Google Scholar 

Gaggiotti-Marre S, Martinez F, Coll L, Garcia S, Álvarez M, Parriego M, et al. Low serum progesterone the day prior to frozen embryo transfer of euploid embryos is associated with significant reduction in live birth rates. Gynecol Endocrinol. 2019;35:439–42.

Article  CAS  PubMed  Google Scholar 

Labarta E, Mariani G, Holtmann N, Celada P, Remohí J, Bosch E. Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study. Hum Reprod. 2017;32:2437–42.

Article  CAS  PubMed  Google Scholar 

Melo P, Chung Y, Pickering O, Price MJ, Fishel S, Khairy M, et al. Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis. Fertil Steril. 2021;116:1534–56.

Article  CAS  PubMed  Google Scholar 

Ranisavljevic N, Huberlant S, Montagut M, Alonzo P-M, Darné B, Languille S, et al. Low luteal serum progesterone levels are associated with lower ongoing pregnancy and live birth rates in ART: systematic review and meta-analyses. Front Endocrinol (Lausanne). 2022;13:892753.

Article  PubMed  PubMed Central  Google Scholar 

Toriumi R, Horikawa M, Sato C, Shimamura N, Ishii R, Terashima M, et al. The addition of dydrogesterone improves the outcomes of pregnant women with low progesterone levels when receiving vaginal progesterone alone as luteal support in HRT-FET cycles. Reprod Med Biol. 2023;22:e12511.

Article  PubMed  PubMed Central  Google Scholar 

Stavridis. Effectiveness of progesterone rescue in women presenting low circulating progesterone levels around the day of embryo transfer: a systematic review and meta-analysis. Fertil Steril. 2023;119:954–63.

Article  CAS  PubMed  Google Scholar 

Álvarez M, Gaggiotti-Marre S, Martínez F, Coll L, García S, González-Foruria I, et al. Individualised luteal phase support in artificially prepared frozen embryo transfer cycles based on serum progesterone levels: a prospective cohort study. Hum Reprod. 2021;36:1552–60.

Article  PubMed  Google Scholar 

Yarali H, Polat M, Mumusoglu S, Ozbek IY, Erden M, Bozdag G, et al. Subcutaneous luteal phase progesterone rescue rectifies ongoing pregnancy rates in hormone replacement therapy vitrified–warmed blastocyst transfer cycles. Reprod Biomed Online. 2021;43:45–51.

Article  CAS  PubMed  Google Scholar 

Labarta E, Mariani G, Rodríguez-Varela C, Bosch E. Individualized luteal phase support normalizes live birth rate in women with low progesterone levels on the day of embryo transfer in artificial endometrial preparation cycles. Fertil Steril. 2022;117:96–103.

Article  CAS  PubMed  Google Scholar 

Tournaye H, Sukhikh GT, Kahler E, Griesinger G. A phase III randomized controlled trial comparing the efficacy, safety and tolerability of oral dydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization. Hum Reprod. 2017;32:1019–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macedo LCGMde, Cavagna Neto M, Dzik A, Rocha AdoR, Lima SMRR. Oral dydrogesterone in frozen-thawed embryo transfer cycles. Rev Assoc Med Bras. 2022;68:100–5.

Article  PubMed  Google Scholar 

Metello J, Tomas C, Ferreira P, Santos-Ribeiro S. The addition of dydrogesterone after frozen embryo transfer in hormonal substituted cycles with low progesterone levels. Rev Bras Ginecol Obstet. 2022;44:930–7.

Article  PubMed  PubMed Central  Google Scholar 

du Boulet B, Ranisavljevic N, Mollevi C, Bringer-Deutsch S, Brouillet S, Anahory T. Individualized luteal phase support based on serum progesterone levels in frozen-thawed embryo transfer cycles maximizes reproductive outcomes in a cohort undergoing preimplantation genetic testing. Front Endocrinol (Lausanne). 2022;13:1051857.

Article  PubMed  PubMed Central  Google Scholar 

Mackens S, Pais F, Drakopoulos P, Amghizar S, Roelens C, Van Landuyt L, et al. Individualized luteal phase support using additional oral dydrogesterone in artificially prepared frozen embryo transfer cycles: is it beneficial? Reprod Biomed Online. 2023;46:939–45.

Article  PubMed  Google Scholar 

Lecourt A, Labrosse J, Peigné M, Vinolas C, Laup L, Sifer C, et al. Addition of dydrogesterone to vaginal progesterone and transfer postponement improve outcomes in patients with low progesterone levels in hormonally substituted cycles for frozen-thawed embryo transfer. Clin J Obstet Gynecol. 2022;5:027–35.

Article  Google Scholar 

Holte J, Berglund L, Milton K, Garello C, Gennarelli G, Revelli A, et al. Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval. Hum Reprod. 2007;22:548–57.

Article  CAS  PubMed  Google Scholar 

Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999;11:307.

Article  CAS  PubMed  Google Scholar 

Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, De Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care, 2017†‡§. Hum Reprod. 2017;32:1786–801.

Article  PubMed  PubMed Central  Google Scholar 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62:e1-34.

Article  PubMed  Google Scholar 

Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–5. https://doi.org/10.1007/s10654-010-9491-z.

Cedrin Durnerin I. La supplémentation lutéale en AMP : une clé du succès à reconsidérer avec plus d’attention. Gynecol Obstet Fertil Senol. 2022;50(6):453–454.

Labarta E, Mariani G, Paolelli S, Rodriguez-Varela C, Vidal C, Giles J, et al. Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone. Hum Reprod. 2021;36:683–92.

Article  CAS  PubMed  Google Scholar 

Jordan J, Craig K, Clifton DK, Soules MR. Luteal phase defect: the sensitivity and specificity of diagnostic methods in common clinical use **Supported by grants RO1 HD 18967 (M.R.S.) and MO1 RR00037 (Clinical Research Center, University of Washington, Seattle, Washington). Fertil Steril. 1994;62:54–62.

Hull MGR, Savage PE, Bromham DR, Ismail AAA, Morris AF. The value of a single serum progesterone measurement in the midluteal phase as a criterion of a potentially fertile cycle (“ovulation”) derived from treated and untreated conception cycles. Fertil Steril. 1982;37:355–60.

Article  CAS  PubMed  Google Scholar 

Volovsky M, Pakes C, Rozen G, Polyakov A. Do serum progesterone levels on day of embryo transfer influence pregnancy outcomes in artificial frozen-thaw cycles? J Assist Reprod Genet. 2020;37:1129–35.

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Liu M, Fu Q, Deng C. Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study. Drug Des Devel Ther. 2019;13:2475–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labarta E, Sebastian-Leon P, Devesa-Peiro A, Celada P, Vidal C, Giles J, et al. Analysis of serum and endometrial progesterone in determining endometrial receptivity. Hum Reprod. 2021;36:2861–70.

Article  CAS 

Comments (0)

No login
gif