Cedars MI. Managing poor ovarian response in the patient with diminished ovarian reserve. Fertil Steril. 2022;117:655–6.
Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2015;103:e9-17.
Jaswa EG, McCulloch CE, Simbulan R, Cedars MI, Rosen MP. Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity. Fertil Steril. 2021;115:966–73.
Article CAS PubMed Google Scholar
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM, Cohen-Bacrie P. Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertil Steril. 2004;82:1323–9.
Article CAS PubMed Google Scholar
Honorato TC, Henningsen AA, Haadsma ML, Land JA, Pinborg A, Lidegaard Ø, et al. Follicle pool, ovarian surgery and the risk for a subsequent trisomic pregnancy. Hum Reprod. 2015;30:717–22.
Article CAS PubMed Google Scholar
Tarasconi B, Tadros T, Ayoubi J-M, Belloc S, de Ziegler D, Fanchin R. Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer. Fertil Steril. 2017;108:518–24.
Article CAS PubMed Google Scholar
Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23:699–708.
Liu X, Wen W, Wang T, Tian L, Li N, Sun T, et al. Increased versus standard gonadotrophin dosing in predicted poor responders of IVF: an open-label randomized controlled trial. Hum Reprod. 2022;37:1806–15.
Article CAS PubMed Google Scholar
Revelli A, Gennarelli G, Sestero M, Canosa S, Carosso A, Salvagno F, et al. A prospective randomized trial comparing corifollitropin-α late-start (day 4) versus standard administration (day 2) in expected poor, normal, and high responders undergoing controlled ovarian stimulation for IVF. J Assist Reprod Genet. 2020;37:1163–70.
Article PubMed PubMed Central Google Scholar
Massin N, Abdennebi I, Porcu-Buisson G, Chevalier N, Descat E, Piétin-Vialle C, et al. The BISTIM study: a randomized controlled trial comparing dual ovarian stimulation (duostim) with two conventional ovarian stimulations in poor ovarian responders undergoing IVF. Hum Reprod. 2023;38:927–37.
Article CAS PubMed PubMed Central Google Scholar
Wiser A, Gonen O, Ghetler Y, Shavit T, Berkovitz A, Shulman A. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod. 2010;25:2496–500.
Article CAS PubMed Google Scholar
Norman RJ, Alvino H, Hull LM, Mol BW, Hart RJ, Kelly T-L, et al. Human growth hormone for poor responders: a randomized placebo-controlled trial provides no evidence for improved live birth rate. Reprod Biomed Online. 2019;38:908–15.
Article CAS PubMed Google Scholar
Zhang S, Tang Y, Wang X, Zong Y, Li X, Cai S, et al. Estrogen valerate pretreatment with the antagonist protocol does not increase oocyte retrieval in patients with low ovarian response: a randomized controlled trial. Hum Reprod. 2022;37:1431–9.
Article CAS PubMed Google Scholar
Barrenetxea G, Agirregoikoa JA, Jiménez MR, de Larruzea AL, Ganzabal T, Carbonero K. Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles. Fertil Steril. 2008;89:546–53.
Article CAS PubMed Google Scholar
Kucuk T, Sozen E. Luteal start of exogenous FSH in poor responder women. J Assist Reprod Genet. 2007;24:635–8.
Article PubMed PubMed Central Google Scholar
Bastu E, Buyru F, Ozsurmeli M, Demiral I, Dogan M, Yeh J. A randomized, single-blind, prospective trial comparing three different gonadotropin doses with or without addition of letrozole during ovulation stimulation in patients with poor ovarian response. Eur J Obstet Gynecol Reprod Biol. 2016;203:30–4.
Article CAS PubMed Google Scholar
Moffat R, Hansali C, Schoetzau A, Ahler A, Gobrecht U, Beutler S, et al. Randomised controlled trial on the effect of clomiphene citrate and gonadotropin dose on ovarian response markers and IVF outcomes in poor responders. Hum Reprod. 2021;36:987–97.
Article CAS PubMed Google Scholar
Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA. The effect of Myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial. Reprod Biol Endocrinol. 2021;19:61.
Article CAS PubMed PubMed Central Google Scholar
Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16:29.
Article PubMed PubMed Central Google Scholar
Lok IH, Yip S-K, Cheung LP, Yin Leung PH, Haines CJ. Adjuvant low-dose aspirin therapy in poor responders undergoing in vitro fertilization: a prospective, randomized, double-blind, placebo-controlled trial. Fertil Steril. 2004;81:556–61.
Conforti A, Carbone L, Di Girolamo R, Iorio GG, Guida M, Campitiello MR, et al. Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2025;123:457–76.
Zhang Y, Zhang C, Shu J, Guo J, Chang H-M, Leung PCK, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26:247–63.
Article CAS PubMed Google Scholar
Ferraretti AP, La Marca A, Fauser BCJM, Tarlatzis B, Nargund G, Gianaroli L, et al. ESHRE consensus on the definition of “poor response” to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616–24.
Article CAS PubMed Google Scholar
Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10:ED000142.
Mbuagbaw L, Rochwerg B, Jaeschke R, Heels-Andsell D, Alhazzani W, Thabane L, et al. Approaches to interpreting and choosing the best treatments in network meta-analyses. Syst Rev. 2017;6:79.
Article CAS PubMed PubMed Central Google Scholar
Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366: l4898.
Nikolakopoulou A, Higgins JPT, Papakonstantinou T, Chaimani A, Del Giovane C, Egger M, et al. CINeMA: An approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020;17: e1003082.
Article PubMed PubMed Central Google Scholar
Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. 2017;108:393–406.
Song J-Y, Gao D-D, Cao X-L, Xiang S, Chen Y-H, Teng Y-L, et al. The role of traditional chinese formula Ding-Kun Pill (DKP) in expected poor ovarian response women (POSEIDON Group 4) undergoing in vitro fertilization-embryo transfer: a multicenter, randomized, double-blind, placebo-controlled trial. Front Endocrinol (Lausanne). 2021;12: 675997.
Davar R, Oskouian H, Ahmadi S, Firouzabadi RD. GnRH antagonist/letrozole versus microdose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization. Taiwan J Obstet Gynecol. 2010;49:297–301.
Karimzadeh MA, Mashayekhy M, Mohammadian F, Moghaddam FM. Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders. Arch Gynecol Obstet. 2011;283:1159–64.
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