Agarwal A, Esteves SC (2016 Mar-Apr) Varicocele and male infertility: current concepts and future perspectives. Asian J Androl 18(2):161–162. https://doi.org/10.4103/1008-682X.172819PMID: 26780875; PMCID: PMC4770479
Chiba K, Fujisawa M (2016) Clinical outcomes of varicocele repair in infertile men: a review. World J Mens Health 34(2):101–109. https://doi.org/10.5534/wjmh.2016.34.2.101
Article PubMed PubMed Central Google Scholar
Khan SA, Kulkarni VR, Shah RS, Gokral JS, Meherji PK, Vadigoppula AD, Patil AD, Bhurke AV, Kokate PP, Barai RS, Surve SR, Modi DN, Mahale SD, Gajbhiye RK (2021) Clinical presentations and semen characteristics of men attending the secondary referral infertility clinic at Mumbai, India. J Hum Reprod Sci 14(4):356–364. https://doi.org/10.4103/jhrs.jhrs_93_21
Article PubMed PubMed Central Google Scholar
Garg H, Kumar R (2016) An update on the role of medical treatment including antioxidant therapy in varicocele. Asian J Androl 18(2):222–228
Article CAS PubMed PubMed Central Google Scholar
Tiseo BC, Esteves SC, Cocuzza MS (2016) Summary evidence on the effects of varicocele treatment to improve natural fertility in subfertile men. Asian J Androl 18(2):239–245
Article CAS PubMed PubMed Central Google Scholar
Shabana W, Teleb M, Dawod T, Elsayed E, Desoky E, Shahin A, Eladl, Sorour W (2015) Predictors of improvement in semen parameters after varicocelectomy for male subfertility: A prospective study. Can Urol Assoc J. 9(9–10):E579-82. https://doi.org/10.5489/cuaj.2808
Arya D, Balasinor N, Singh D (2022) Varicocoele-associated male infertility: cellular and molecular perspectives of pathophysiology. Andrology 10(8):1463–1483
Article CAS PubMed Google Scholar
Jenkins TG, Carrell DT (2012) The sperm epigenome and potential implications for the developing embryo. Reproduction 143(6):727–34. https://doi.org/10.1530/REP-11-0450
Article CAS PubMed Google Scholar
Talbert PB, Henikoff S (2006) Spreading of silent chromatin: inaction at a distance. Nat Rev Genet 7(10):793–803. https://doi.org/10.1038/nrg1920
Article CAS PubMed Google Scholar
Takai D, Jones PA (2002) Comprehensive analysis of CpG Islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A 99(6):3740–3745. https://doi.org/10.1073/pnas.052410099052410099
Article CAS PubMed PubMed Central Google Scholar
Moore LD, Le T, Fan G (2013) DNA methylation and its basic function. Neuropsychopharmacology 38(1):23–38. https://doi.org/10.1038/npp.2012.112
Article CAS PubMed Google Scholar
Cho C, Jung-Ha H, Willis WD et al (2003) Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice. BiolReprod 69(1):211–217. https://doi.org/10.1095/biolreprod.102.015115
Aston KI, Punj V, Liu L, Carrell DT (2012) Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis. Fertil Steril 97:285–292. https://doi.org/10.1016/j.fertnstert.2011.11.008
Article CAS PubMed Google Scholar
Sanyal D, Arya D, Nishi K, Balasinor N, Singh D (2024) Clinical utility of sperm function tests in predicting male fertility: a systematic review. Reprod Sci 31(4):863–882. https://doi.org/10.1007/s43032-023-01405-7
Article CAS PubMed Google Scholar
WHO laboratory manual for the examination and processing of human semen, 6th ed. ISBN: 978 92 40030787
Arya D, Pawar P, Gajbhiye R, Tandon D, Kothari P, Goankar R, Singh D (2025) Status of sperm mitochondrial functions and DNA methylation in infertile men with clinical varicocele before and after treatment. Mol Cell Endocrinol 595:112393. https://doi.org/10.1016/j.mce.2024.112393
Article CAS PubMed Google Scholar
Khambata K, Begum S, Raut S, Mohan S, Irani D, Singh D, Bansal V, Patil A, Balasinor NH (2023) DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss. Epigenetics 18(1):2252244
Article PubMed PubMed Central Google Scholar
Irani D, Balasinor N, Bansal V, Tandon D, Patil A, Singh D (2023) Whole genome bisulfite sequencing of sperm reveals differentially methylated regions in male partners of idiopathic recurrent pregnancy loss cases. Fertil Steril 119(3):420–432
Article CAS PubMed Google Scholar
Dubin L, Amelar RD (1970) Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril 21(8):606–609. https://doi.org/10.1016/s0015-0282(16)37684-1
Article CAS PubMed Google Scholar
Agarwal A, Sharma R, Harlev A, Esteves SC (2016 Mar-Apr) Effect of varicocele on semen characteristics according to the new 2010 world health organization criteria: a systematic review and meta-analysis. Asian J Androl 18(2):163–170 PMID: 26780872; PMCID: PMC4770480. https://doi.org/10.4103/1008-682X.172638
Xue J, Yang J, Yan J, Jiang X, He LY, Wu T, Guo J (2012) Abnormalities of the testes and semen parameters in clinical varicocele. Nan Fang Yi Ke Da Xue Xue Bao 32(4):439–442 PMID: 22543118
Kadioglu TC, Aliyev E, Celtik M (2014) Microscopic varicocelectomy significantly decreases the sperm DNA fragmentation index in patients with infertility. BioMed Res Int 2014:2014:695713. https://doi.org/10.1155/2014/695713
Article CAS PubMed Google Scholar
Shebl SE, Sabry K (2022) Semen parameters changes in adolescents with clinical varicocele after magnified subinguinal varicocelectomy: a prospective controlled study. Am J Mens Health 16(6):15579883221141808. https://doi.org/10.1177/15579883221141808
Article PubMed PubMed Central Google Scholar
Hassanzadeh-Nokashty K, Yavarikia P, Ghaffari A, Hazhir S, Hassanzadeh M (2011) Effect of age on semen parameters in infertile men after varicocelectomy. Ther Clin Risk Manag 7:333–336
PubMed PubMed Central Google Scholar
Yi SV, Goodisman MA (2009) Computational approaches for understanding the evolution of DNA methylation in animals. Epigenetics 4:551–556
Article CAS PubMed Google Scholar
Dada R, Kumar M, Jesudasan R, Fernández JL, Gosálvez J, Agarwal A (2012) Epigenetics and its role in male infertility. J Assist Reprod Genet 29(3):213–223. https://doi.org/10.1007/s10815-012-9715-0PMID: 22290605; PMCID: PMC3288140
Article PubMed PubMed Central Google Scholar
Keshet I, Yisraeli J, Cedar H (1985) Effect of regional DNA methylation on gene expression. Proc Natl Acad Sci U S A 82:2560–2564
Article CAS PubMed PubMed Central Google Scholar
Güneş S, Kulaç T (2013) The role of epigenetics in spermatogenesis. Turk J Urol 39(3):181–187. https://doi.org/10.5152/tud.2013.037PMID: 26328105; PMCID: PMC4548616
Article PubMed PubMed Central Google Scholar
Santana VP, Miranda-Furtado CL, Pedroso DCC et al (2019) The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases. Syst Biol Reprod Med 65(2):95–104. https://doi.org/10.1080/19396368.2018.1557762
Article CAS PubMed Google Scholar
Bahreinian M, Tavalaee M, Abbasi H, Kiani-Esfahani A, Shiravi AH, Nasr-Esfahani MH (2015) DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. Syst Biol Reprod Med 61(4):179–186. https://doi.org/10.3109/19396368.2015.1020116
Article CAS PubMed Google Scholar
Tavalaee M, Bahreinian M, Barekat F, Abbasi H, Nasr-Esfahani MH (2015) Effect of varicocelectomy on sperm functional characteristics and DNA methylation. Andrologia 47(8):904–909. https://doi.org/10.1111/and.12345
Article CAS PubMed Google Scholar
Santana VP, James ER, Miranda-Furtado CL et al (2020) Differential DNA methylation pattern and sperm quality in men with varicocele. Fertil Steril 114(4):770–778. https://doi.org/10.1016/j.fertnstert.2020.04.045
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