Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W (2023) European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the study of adrenal tumors. Eur J Endocrinol 189:G1–G42. https://doi.org/10.1093/ejendo/lvae022

Article  PubMed  Google Scholar 

Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekić AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivović M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdés N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistrè A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iñiguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M (2022) Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study. Lancet Diabetes Endocrinol 10:499–508. https://doi.org/10.1016/S2213-8587(22)00100-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prete A, Subramanian A, Bancos I, Chortis V, Tsagarakis S, Lang K, Macech M, Delivanis DA, Pupovac ID, Reimondo G, Marina LV (2022) Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study. Ann Intern Med 175(3):325–334. https://doi.org/10.7326/M21-1737

Article  PubMed  Google Scholar 

Elhassan YS, Alahdab F, Prete A, Delivanis DA, Khanna A, Prokop L, Murad MH, O’Reilly MW, Arlt W, Bancos I (2019) Natural history of adrenal incidentalomas with and without mild autonomous cortisol excess: a systematic review and meta-analysis. Ann Intern Med 171(2):107–116. https://doi.org/10.7326/M18-3630

Article  PubMed  Google Scholar 

Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, Ganzaroli C, Giacchetti G, Letizia C, Maccario M et al (2006) PAPY Study investigators. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol 48:2293–2300. https://doi.org/10.1016/j.jacc.2006.07.059

Article  CAS  PubMed  Google Scholar 

Monticone S, D’Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P (2018) Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 6:41–50. https://doi.org/10.1016/S2213-8587(17)30319-4

Article  CAS  PubMed  Google Scholar 

Zuo R, Liu S, Xu L, Pang H (2023) Key to the treatment of primary aldosteronism in secondary hypertension: subtype diagnosis. Curr Hypertens Rep 25:471–480. https://doi.org/10.1007/s11906-023-01269-x

Article  PubMed  Google Scholar 

Phillips JL, Walther MM, Pezzullo JC, Rayford W, Choyke PL, Berman AA, Linehan WM, Doppman JL, Gill JR (2000) Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma. J Clin Endocrinol Metab 85:4526–4533. https://doi.org/10.1210/jcem.85.12.7086

Article  CAS  PubMed  Google Scholar 

Ronchi CL (2019) cAMP/protein kinase a signalling pathway and adrenocortical adenomas. Curr Opin Endocr Metabolic Res 8:15–21. https://doi.org/10.1016/j.coemr.2019.06.003

Article  Google Scholar 

Ronchi CL, Di Dalmazi G, Sbiera S, Assié G, Weigand I, Calebiro D, Waldmann J (2016) Genetic landscape of sporadic unilateral adrenocortical adenomas without PRKACA p. Leu206Arg mutation. J Clin Endocrinol Metabolism 101:3526–3538. https://doi.org/10.1210/jc.2016-1586

Article  CAS  Google Scholar 

Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP (2015) A meta-analysis of somatic KCNJ5 K + channel mutations in 1636 patients with an aldosterone-producing adenoma. J Clin Endocrinol Metabolism 100:E1089–E1095. https://doi.org/10.1210/jc.2015-2149

Article  CAS  Google Scholar 

Wu VC, Wang SM, Chueh SCJ, Yang SY, Huang KH, Lin YH, Wang JJ, Connolly R, Hu YH, Gomez-Sanchez CE, Peng KY (2017) The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes. Sci Rep 7:39121. https://doi.org/10.1038/srep39121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O (2021) What did we learn from the molecular biology of adrenal cortical neoplasia? From histopathology to translational genomics. Endocr Pathol 32:102–133. https://doi.org/10.1007/s12022-021-09667-0

Article  CAS  PubMed  Google Scholar 

Vymetalkova V, Cervena K, Bartu L, Vodicka P (2018) Circulating cell-free DNA and colorectal cancer: a systematic review. Int J Mol Sci 19:3356. https://doi.org/10.3390/ijms19113356

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehrotra M, Singh RR, Loghavi S, Duose DY, Barkoh BA, Behrens C, Patel KP, Routbort MJ, Kopetz S, Broaddus RR, Medeiros LJ (2018) Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors. Oncotarget 9:10259. https://doi.org/10.18632/oncotarget.21982

Article  PubMed  Google Scholar 

Lippert J, Smith G, Appenzeller S, Landwehr LS, Prete A, Steinhauer S, Asia M, Urlaub H, Elhassan YS, Kircher S, Arlt W, Fassnacht M, Altieri B, Ronchi CL (2024) Circulating cell-free DNA-based biomarkers for prognostication and diease monitoring in adrenocortical carcinoma. Eur J Endocrinol 190:234–247. https://doi.org/10.1093/ejendo/lvae022

Article  PubMed  Google Scholar 

Danese E, Montagnana M, Minicozzi AM, De Matteis G, Scudo G, Salvagno GL, Cordiano G, Lippi G, Guidi GC (2010) Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers. Clin Chem Lab Med 48:1665–1668. https://doi.org/10.1515/CCLM.2010.301

Article  CAS  PubMed  Google Scholar 

Kohler C, Radpour R, Barekati Z, Asadollahi R, Bitzer J, Wight E, Bürki N, Holzgreve W, Zhong X (2009) Levels of plasma circulating cell-free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer 8:105. https://doi.org/10.1186/1476-4598-8-105

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao S, Yu S, Yin Y, Su L, Hong S, Gong Y, Lv W, Li Y, Xiao H (2020) Genetic alterations in cfDNA of benign and malignant thyroid nodules based on amplicon-based next-generation sequencing. Annals Translational Med 8:1225. https://doi.org/10.21037/atm-20-4544

Article  CAS  Google Scholar 

Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, Stowasser M, Young Jr WF (2016) The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin Endocrinol Metabolism 101(5):1889–1916. https://doi.org/10.1210/jc.2015-4061

Article  CAS  Google Scholar 

Bieler J, Kubik S, Macheret M et al (2023) Benefits of applying molecular barcoding systems are not uniform across different genomic applications. J Translational Med 21:1–13. https://doi.org/10.1186/s12967-023-04160-0

Article  Google Scholar 

Williams TA, Lenders JW, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F (2017) Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 5:689–699. https://doi.org/10.1016/S2213-8587(17)30135-3

Article  PubMed  PubMed Central  Google Scholar 

Pitsava G, Stratakis CA (2022) Genetic alterations in benign adrenal tumors. Biomedicines 10(5):1041. https://doi.org/10.3390/biomedicines10051041

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barzon L, Fallo F, Sonino N, Boscaro M (2002) Development of overt Cushing’s syndrome in patients with adrenal incidentaloma. Eur J Endocrinol 146:61–66. https://doi.org/10.1530/eje.0.1460061

Article  CAS  PubMed  Google Scholar 

Chang YY, Tsai CH, Peng SY, Chen ZW, Chang CC, Lee BC, Liao CW, Pan CT, Chen YL, Lin LC, Chang YR (2021) KCNJ5 somatic mutations in aldosterone-producing adenoma are associated with a worse baseline status and better recovery of left ventricular remodeling and diastolic function. Hypertension 77(1):114–125. https://doi.org/10.1161/HYPERTENSIONAHA.120.15679

Article  CAS  PubMed  Google Scholar 

Favero V, Prete A, Mangone A, Elhassan YS, Pucino V, Asia M, Hardy R, Chiodini I, Ronchi CL (2023) Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study. Eur J Endocrinol 189:517–526. https://doi.org/10.1093/ejendo/lvad151

Article  PubMed  Google Scholar 

Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H (2014) Recurrent somatic mutations underlie corticotropin-independent Cushing’s syndrome. Science