Modern Management of Fournier’s Gangrene

Sorensen MD, Krieger JN, Rivara FP, Broghammer JA, Klein MB, Mack CD, et al. Fournier’s gangrene: population based epidemiology and outcomes. J Urol. 2009;181(5):2120–6.

Article  PubMed  PubMed Central  Google Scholar 

Lewis GD, Majeed M, Olang CA, Patel A, Gorantla VR, Davis N, et al. Fournier’s gangrene diagnosis and treatment: A systematic review. Cureus. 2021;13(10):e18948.

PubMed  PubMed Central  Google Scholar 

Beecroft NJ, Jaeger CD, Rose JR, Becerra CMC, Shah NC, Palettas MS, et al. Fournier’s gangrene in females: presentation and management at a tertiary center. Urology. 2021;151:113–7.

Article  PubMed  Google Scholar 

Abbasi B, Hacker E, Ghaffar U, Hakam N, Li KD, Alazzawi S, et al. Higher morbidity and mortality in females with Fournier gangrene compared with males: insights from National inpatient sample data. J Urol. 2025;213(1):99–109.

PubMed  Google Scholar 

Wróblewska M, Kuzaka B, Borkowski T, Kuzaka P, Kawecki D, Radziszewski P. Fournier’s gangrene–current concepts. Pol J Microbiol. 2014;63(3):267–73.

Article  PubMed  Google Scholar 

Fadini GP, Sarangdhar M, De Ponti F, Avogaro A, Raschi E. Pharmacovigilance assessment of the association between Fournier’s gangrene and other severe genital adverse events with SGLT-2 inhibitors. BMJ Open Diabetes Res Care. 2019;7(1):e000725.

Article  PubMed  PubMed Central  Google Scholar 

Silverii GA, Dicembrini I, Monami M, Mannucci E. Fournier’s gangrene and sodium-glucose co-transporter-2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2020;22(2):272–5.

Article  CAS  PubMed  Google Scholar 

Radcliffe RS, Khan MA. Mortality associated with Fournier’s gangrene remains unchanged over 25 years. BJU Int. 2020;125(4):610–6.

Article  PubMed  Google Scholar 

Furr J, Watts T, Street R, Cross B, Slobodov G, Patel S. Contemporary trends in the inpatient management of Fournier’s gangrene: predictors of length of stay and mortality based on Population-based sample. Urology. 2017;102:79–84.

Article  PubMed  Google Scholar 

Bowen D, Juliebø-Jones P, Somani BK. Global outcomes and lessons learned in the management of Fournier’s gangrene from high-volume centres: findings from a literature review over the last two decades. World J Urol. 2022;40(10):2399–410.

Article  PubMed  Google Scholar 

Tazeoglu D, Benli S, Esmer AC, Colak T, Apaydin FD. Effect of sarcopenia on mortality and morbidity in patients with Fournier’s gangrene. Am Surg. 2023;89(12):5527–34.

Article  PubMed  Google Scholar 

El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, et al. Fournier’s gangrene mortality: A 17-year systematic review and meta-analysis. Int J Infect Dis. 2020;92:218–25.

Article  PubMed  Google Scholar 

Osbun N, Hampson LA, Holt SK, Gore JL, Wessells H, Voelzke BB. Low-Volume vs High-Volume centers and management of Fournier’s gangrene in Washington state. J Am Coll Surg. 2017;224(3):270–e51.

Article  PubMed  Google Scholar 

Laor E, Palmer LS, Tolia BM, Reid RE, Winter HI. Outcome prediction in patients with Fournier’s gangrene. J Urol. 1995;154(1):89–92.

Article  CAS  PubMed  Google Scholar 

Yilmazlar T, Ozturk E, Ozguc H, Ercan I, Vuruskan H, Oktay B. Fournier’s gangrene: an analysis of 80 patients and a novel scoring system. Tech Coloproctol. 2010;14(3):217–23.

Article  CAS  PubMed  Google Scholar 

Tufano A, Dipinto P, Passaro F, Anceschi U, Franco G, Flammia RS et al. The Value of Fournier’s Gangrene Scoring Systems on Admission to Predict Mortality: A Systematic Review and Meta-Analysis. J Pers Med. 2023;13(9).

Arıkan Y, Emir B, Tarhan O, Koras Ö, Ozlu DN, Sungur U, et al. Comparative analysis of scoring systems for predicting mortality in Fournier gangrene: single center, 15 years experience. Updates Surg. 2024;76(7):2683–92.

Article  PubMed  Google Scholar 

Eray IC, Dalci K, Gumus S, Yalav O, Saritas AG, Boz A, et al. The role of C-reactive protein ratio in predicting mortality in patients with Fournier gangrene. Ann Coloproctol. 2023;39(3):223–30.

Article  PubMed  Google Scholar 

Altarac S, Katušin D, Crnica S, Papeš D, Rajković Z, Arslani N. Fournier’s gangrene: etiology and outcome analysis of 41 patients. Urol Int. 2012;88(3):289–93.

Article  PubMed  Google Scholar 

Morpurgo E, Galandiuk S. Fournier’s gangrene. Surg Clin North Am. 2002;82(6):1213–24.

Article  PubMed  Google Scholar 

Leslie SW, Rad J, Foreman J. Fournier gangrene. StatPearls. Treasure Island (FL): StatPearls publishing copyright © 2025. StatPearls Publishing LLC.; 2025.

Alyanak A, Cakici OU, Turkmen YA. Skin-sparing approach in the management of Fournier’s gangrene: the initial histological evidence and results of a tertiary health-care center. ANZ J Surg. 2022;92(1–2):128–31.

Article  PubMed  Google Scholar 

Eke N. Fournier’s gangrene: a review of 1726 cases. Br J Surg. 2000;87(6):718–28.

Article  CAS  PubMed  Google Scholar 

He X, Xiang X, Zou Y, Liu B, Liu L, Bi Y, et al. Distinctions between Fournier’s gangrene and lower extremity necrotising fasciitis: microbiology and factors affecting mortality. Int J Infect Dis. 2022;122:222–9.

Article  PubMed  Google Scholar 

Huayllani MT, Cheema AS, McGuire MJ, Janis JE. Practical review of the current management of Fournier’s gangrene. Plast Reconstr Surg Glob Open. 2022;10(3):e4191.

Article  PubMed  PubMed Central  Google Scholar 

Zhang N, Yu X, Zhang K, Liu T. A retrospective case series of Fournier’s gangrene: necrotizing fasciitis in perineum and perianal region. BMC Surg. 2020;20(1):259.

Article  PubMed  PubMed Central  Google Scholar 

Martinez M, Peponis T, Hage A, Yeh DD, Kaafarani HMA, Fagenholz PJ, et al. The role of computed tomography in the diagnosis of necrotizing soft tissue infections. World J Surg. 2018;42(1):82–7.

Article  PubMed  Google Scholar 

Chen F, Neill E, Graglia S. Point-of-care ultrasound for the diagnosis of Fournier gangrene. Emerg Med J. 2023;40(9):682–5.

Article  PubMed  Google Scholar 

Elmi AM, Kusbeci M, Osoble Osman FA. A case report of Fournier’s gangrene: imaging ultrasound and computed tomography (CT) scan. Radiol Case Rep. 2022;17(3):959–62.

Article  PubMed  PubMed Central  Google Scholar 

Sumisławski P, Kołecki J, Piotrowska M, Kotowski M, Szemitko M, Sieńko J. Utility of diagnostic imaging in the early detection and management of the Fournier gangrene. Diagnostics (Basel). 2022;12(10).

Koch GE, Launer BM, Li AN, Johnsen NV. A Disease-Specific antibiogram to evaluate empiric coverage patterns in Fournier’s gangrene. Urology. 2023;178:162–6.

Article  PubMed  Google Scholar 

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59(2):e10–52.

Article  PubMed  Google Scholar 

Lucca M, Unger HD, Devenny AM. Treatment of Fournier’s gangrene with adjunctive hyperbaric oxygen therapy. Am J Emerg Med. 1990;8(5):385–7.

Article  CAS  PubMed  Google Scholar 

Capelli-Schellpfeffer M, Gerber GS. The use of hyperbaric oxygen in urology. J Urol. 1999;162(3 Pt 1):647–54.

Article  CAS  PubMed  Google Scholar 

George ME, Rueth NM, Skarda DE, Chipman JG, Quickel RR, Beilman GJ. Hyperbaric oxygen does not improve outcome in patients with necrotizing soft tissue infection. Surg Infect (Larchmt). 2009;10(1):21–8.

Article  PubMed  Google Scholar 

Huang C, Zhong Y, Yue C, He B, Li Y, Li J. The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis. World J Emerg Surg. 2023;18(1):23.

Article  PubMed  PubMed Central  Google Scholar 

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