Lagarde, S. et al. Interictal stereotactic-EEG functional connectivity in refractory focal epilepsies. Brain 141, 2966–2980 (2018).

Article  PubMed  Google Scholar 

Hermann, B. P. et al. Cognitive prognosis in chronic temporal lobe epilepsy. Ann. Neurol. 60, 80–87 (2006).

Article  PubMed  Google Scholar 

Kwan, P. & Brodie, M. J. Early identification of refractory epilepsy. N. Engl. J. Med. 342, 314–319 (2000).

Article  CAS  PubMed  Google Scholar 

Perrine, K. et al. The relationship of neuropsychological functioning to quality of life in epilepsy. Arch. Neurol. 52, 997–1003 (1995).

Article  CAS  PubMed  Google Scholar 

Boylan, L. S. et al. Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 62, 258–261 (2004).

Article  CAS  PubMed  Google Scholar 

Reed, C. M. et al. Extent of single-neuron activity modulation by hippocampal interictal discharges predicts declarative memory disruption in humans. J. Neurosci. 40, 682–693 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kleen, J. K. et al. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology 81, 18–24 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortinski, P. & Meador, K. J. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 5, 60–65 (2004).

Article  Google Scholar 

Chvojka, J. et al. The role of interictal discharges in ictogenesis—a dynamical perspective. Epilepsy Behav. 121, 106591 (2021).

Article  PubMed  Google Scholar 

Dempsey, E. W. & Morison, R. S. The production of rhythmically recurrent cortical potentials after localized thalamic stimulation. Am. J. Physiol. 135, 293–300 (1941).

Article  Google Scholar 

Chase, M. H., Nakamura, Y., Clemente, C. D. & Sterman, M. B. Afferent vagal stimulation: neurographic correlates of induced EEG synchronization and desynchronization. Brain Res. 5, 236–249 (1967).

Article  CAS  PubMed  Google Scholar 

Khodagholy, D., Ferrero, J. J., Park, J., Zhao, Z. & Gelinas, J. N. Large-scale, closed-loop interrogation of neural circuits underlying cognition. Trends Neurosci. 45, 968–983 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jastrzebska‐Perfect, P. et al. Translational neuroelectronics. Adv. Funct. Mater. 30, 1909165 (2020).

Article  Google Scholar 

Krook-Magnuson, E., Gelinas, J. N., Soltesz, I. & Buzsáki, G. Neuroelectronics and biooptics: closed-loop technologies in neurological disorders. JAMA Neurol. 72, 823–829 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Morrell, M. J. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology 77, 1295–1304 (2011).

Article  PubMed  Google Scholar 

Bergey, G. K. et al. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology 84, 810–817 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toffa, D. H., Touma, L., El Meskine, T., Bouthillier, A. & Nguyen, D. K. Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: a critical review. Seizure 83, 104–123 (2020).

Article  PubMed  Google Scholar 

Chan, A. Y., Rolston, J. D., Rao, V. R. & Chang, E. F. Effect of neurostimulation on cognition and mood in refractory epilepsy. Epilepsia Open 3, 18–29 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Bui, A. D. et al. Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory. Science 359, 787–790 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khodagholy, D., Gelinas, J. N. & Buzsáki, G. Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus. Science 358, 369–372 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siapas, A. G. & Wilson, M. A. Coordinated Interactions between hippocampal ripples and cortical spindles during slow-wave sleep. Neuron 21, 1123–1128 (1998).

Article  CAS  PubMed  Google Scholar 

Girardeau, G. et al. Selective suppression of hippocampal ripples impairs spatial memory. Nat. Neurosci. 12, 1222–1223 (2009).

Article  CAS  PubMed  Google Scholar 

Maingret, N., Girardeau, G., Todorova, R., Goutierre, M. & Zugaro, M. Hippocampo-cortical coupling mediates memory consolidation during sleep. Nat. Neurosci. 19, 959–964 (2016).

Article  CAS  PubMed  Google Scholar 

Gelinas, J. N., Khodagholy, D., Thesen, T., Devinsky, O. & Buzsáki, G. Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy. Nat. Med. 22, 641–648 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu, H. et al. Interaction of interictal epileptiform activity with sleep spindles is associated with cognitive deficits and adverse surgical outcome in pediatric focal epilepsy. Epilepsia 65, 190–203 (2024).

Article  PubMed  Google Scholar 

Dahal, P. et al. Interictal epileptiform discharges shape large-scale intercortical communication. Brain 142, 3502–3513 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Sákovics, A. et al. Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients. Epilepsia 63, 2256 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Buzsáki, G. Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning. Hippocampus 25, 1073–1188 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Shatskikh, T. N., Raghavendra, M., Zhao, Q., Cui, Z. & Holmes, G. L. Electrical induction of spikes in the hippocampus impairs recognition capacity and spatial memory in rats. Epilepsy Behav. 9, 549–556 (2006).

Article  PubMed  Google Scholar 

Bartolomei, F. et al. Defining epileptogenic networks: contribution of SEEG and signal analysis. Epilepsia 58, 1131–1147 (2017).

Article  PubMed  Google Scholar 

Sheybani, L. et al. Wake slow waves in focal human epilepsy impact network activity and cognition. Nat. Commun. 14, 7397 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheybani, L. et al. Slow oscillations open susceptible time windows for epileptic discharges. Epilepsia 62, 2357 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Okadome, T. et al. The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients. Front. Neurol. 13, 979333 (2022).

Article  PubMed  PubMed Central