Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum

Skalkidou A, Hellgren C, Comasco E, Sylven S, Sundstrom Poromaa I. Biological aspects of postpartum depression. Womens Health. 2012;8:659–72.

CAS  Google Scholar 

Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord. 2017;219:86–92.

Article  CAS  PubMed  Google Scholar 

Wang Z, Liu J, Shuai H, Cai Z, Fu X, Liu Y, et al. Mapping global prevalence of depression among postpartum women. Transl Psychiatry. 2021;11:543.

Article  PubMed  PubMed Central  Google Scholar 

Underwood L, Waldie K, D’Souza S, Peterson ER, Morton S. A review of longitudinal studies on antenatal and postnatal depression. Arch Womens Ment Health. 2016;19:711–20.

Article  PubMed  Google Scholar 

Esscher A, Essen B, Innala E, Papadopoulos FC, Skalkidou A, Sundstrom-Poromaa I, et al. Suicides during pregnancy and 1 year postpartum in Sweden, 1980-2007. Br J Psychiatry. 2016;208:462–9.

Article  PubMed  Google Scholar 

Olivier JD, Akerud H, Kaihola H, Pawluski JL, Skalkidou A, Hogberg U, et al. The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring. Front Cell Neurosci. 2013;7:73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chin K, Wendt A, Bennett IM, Bhat A. Suicide and maternal mortality. Curr Psychiatry Rep. 2022;24:239–75.

Article  PubMed  PubMed Central  Google Scholar 

Alawieh A, Zaraket FA, Li JL, Mondello S, Nokkari A, Razafsha M, et al. Systems biology, bioinformatics, and biomarkers in neuropsychiatry. Front Neurosci. 2012;6:187.

Article  PubMed  PubMed Central  Google Scholar 

Guintivano J, Aberg KA, Clark SL, Rubinow DR, Sullivan PF, Meltzer-Brody S, et al. Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance. Mol Psychiatry. 2022;27:2858–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breedh J, Comasco E, Hellgren C, Papadopoulos FC, Skalkidou A, Poromaa IS. Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy. Psychoneuroendocrinology. 2019;106:1–8.

Article  CAS  PubMed  Google Scholar 

Iliadis SI, Sylvén S, Hellgren C, Olivier JD, Schijven D, Comasco E, et al. Mid-pregnancy corticotropin-releasing hormone levels in association with postpartum depressive symptoms. Depress Anxiety. 2016;33:1023–30.

Article  CAS  PubMed  Google Scholar 

Skalkidou A, Poromaa IS, Iliadis SI, Huizink AC, Hellgren C, Freyhult E, et al. Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: a longitudinal population-based study. Psychoneuroendocrinology. 2019;103:296–305.

Article  PubMed  Google Scholar 

McCormack C, Abuaish S, Monk C. Is there an inflammatory profile of perinatal depression? Curr Psychiatry Rep. 2023;25:149–64.

Article  PubMed  Google Scholar 

Bränn E, Fransson E, White RA, Papadopoulos FC, Edvinsson Å, Kamali-Moghaddam M, et al. Inflammatory markers in women with postpartum depressive symptoms. J Neurosci Res. 2020;98:1309–21.

Article  PubMed  Google Scholar 

Comasco E, Hellgren C, Olivier J, Skalkidou A, Sundstrom Poromaa I. Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women. Psychoneuroendocrinology. 2015;60:217–23.

Article  CAS  PubMed  Google Scholar 

Comasco E, Gulinello M, Hellgren C, Skalkidou A, Sylven S, Sundstrom-Poromaa I. Sleep duration, depression, and oxytocinergic genotype influence prepulse inhibition of the startle reflex in postpartum women. Eur Neuropsychopharmacol. 2016;26:767–76.

Article  CAS  PubMed  Google Scholar 

Dye C, Lenz KM, Leuner B. Immune system alterations and postpartum mental illness: evidence from basic and clinical research. Front Glob Womens Health. 2022;2:758748.

Article  PubMed  PubMed Central  Google Scholar 

Mehta D, Newport DJ, Frishman G, Kraus L, Rex-Haffner M, Ritchie JC, et al. Early predictive biomarkers for postpartum depression point to a role for estrogen receptor signaling. Psychol Med. 2014;44:2309–22.

Article  CAS  PubMed  Google Scholar 

Katz ER, Stowe ZN, Newport DJ, Kelley ME, Pace TW, Cubells JF, et al. Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy. Psychol Med. 2012;42:943–56.

Article  CAS  PubMed  Google Scholar 

Mehta D, Grewen K, Pearson B, Wani S, Wallace L, Henders AK, et al. Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Transl Psychiatry. 2021;11:155.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudzinskas SA, Goff AC, Mazzu MA, Schiller CE, Meltzer-Brody S, Rubinow DR, et al. Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression. Mol Psychiatry. 2023.

Pan D, Xu Y, Zhang L, Su Q, Chen M, Li B, et al. Gene expression profile in peripheral blood mononuclear cells of postpartum depression patients. Sci Rep. 2018;8:10139.

Article  PubMed  PubMed Central  Google Scholar 

Osborne LM, Payne JL, Sherer ML, Sabunciyan S. Altered extracellular mRNA communication in postpartum depression is associated with decreased autophagy. Mol Psychiatry. 2022;27:4526–35.

Article  CAS  PubMed  Google Scholar 

Wikman A, Axfors C, Iliadis SI, Cox J, Fransson E, Skalkidou A. Characteristics of women with different perinatal depression trajectories. J Neurosci Res. 2020;98:1268–82.

Article  CAS  PubMed  Google Scholar 

Gammie SC, Driessen TM, Zhao C, Saul MC, Eisinger BE. Genetic and neuroendocrine regulation of the postpartum brain. Front Neuroendocrinol. 2016;42:1–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnova L, Modafferi S, Schlett C, Osborne LM, Payne JL, Sabunciyan S. Blood extracellular vesicles carrying brain-specific mRNAs are potential biomarkers for detecting gene expression changes in the female brain. Mol Psychiatry. 2024;29:962–73.

Article  CAS  PubMed  Google Scholar 

Axfors C, Bränn E, Henriksson HE, Hellgren C, Kunovac Kallak T, Fransson E, et al. Cohort profile: the biology, affect, stress, imaging and cognition (BASIC) study on perinatal depression in a population-based Swedish cohort. BMJ Open. 2019;9:e031514.

Article  PubMed  PubMed Central  Google Scholar 

World Medical Association. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310:2191–4.

Article  Google Scholar 

Wickberg B, Hwang CP. The edinburgh postnatal depression scale: validation on a Swedish community sample. Acta Psychiatr Scand. 1996;94:181–4.

Article  CAS  PubMed  Google Scholar 

Rubertsson C, Börjesson K, Berglund A, Josefsson A, Sydsjö G. The swedish validation of Edinburgh postnatal depression scale (EPDS) during pregnancy [press release]. Nord J Psychiatry. 2011;65:414–8.

Article  PubMed  Google Scholar 

Anders S, Pyl PT, Huber W. HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics. 2014;31:166–9.

Article  PubMed  PubMed Central  Google Scholar 

Zhao X, Liu L. Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women. Front Psychiatry. 2024;15:1287934.

Article  PubMed  PubMed Central 

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