Autophagy Impairment in Parkinson’s Disease: Approaches to Therapy

Rocca W.A. 2018. The burden of Parkinson’s disease: A worldwide perspective. Lancet Neurol. 17 (11), 928‒929. https://doi.org/10.1016/S1474-4422(18)30355-7

Article  PubMed  Google Scholar 

Dorsey E.R., Bloem B.R. 2018. The Parkinson pandemic—a call to action. JAMA Neurol. 75, 9‒10.

Article  PubMed  Google Scholar 

Leentjens A.F.G., Dujardin K., Pontone G.M., Starkstein S.E., Weintraub D., Martinez-Martin P. 2014. The Parkinson anxiety scale (PAS): Development and validation of a new anxiety scale. Mov. Disord. 29 (8), 1035‒1043. https://doi.org/10.1002/mds.25919

Article  PubMed  Google Scholar 

Ben-Shlomo Y., Darweesh S., Llibre-Guerra J., Marras C., San Luciano M., Tanner C. 2024. The epidemiology of Parkinson’s disease. Lancet. 403 (10423), 283‒292. https://doi.org/10.1016/S0140-6736(23)01419-8

Article  PubMed  PubMed Central  Google Scholar 

He S., Zhong S., Liu G., Yang J. 2021. Alpha-synuclein: The interplay of pathology, neuroinflammation, and environmental factors in Parkinson’s disease. Neurodegener. Dis. 20 (2‒3), 55‒64. https://doi.org/10.1159/000511083

Article  CAS  Google Scholar 

Bobela W., Aebischer P., Schneider B.L. 2015. Alpha-synuclein as a mediator in the interplay between aging and Parkinson’s disease. Biomolecules. 5 (4), 2675–2700. https://doi.org/10.3390/biom5042675

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shadrina M.I., Slominsky P.A. 2023. Genetic architecture of Parkinson’s disease. Biochemistry (Moscow). 88, 417–433.

CAS  PubMed  Google Scholar 

Kalia L.V., Lang A.E. 2016. Evolving basic, pathological and clinical concepts in PD. Nat. Rev. Neurol. 12 (2), 65‒66. https://doi.org/10.1038/nrneurol.2015.249

Article  CAS  PubMed  Google Scholar 

Simpson C., Vinikoor-Imler L., Nassan F.L., Shirvan J., Lally C., Dam T., Maserejian N. 2022. Prevalence of ten LRRK2 variants in Parkinson’s disease: A comprehensive review. Parkinsonism Relat. Disord. 98, 103‒113. https://doi.org/10.1016/j.parkreldis.2022.05.012

Article  CAS  PubMed  Google Scholar 

Riboldi G.M., Di Fonzo A.B. 2019. GBA, Gaucher disease, and Parkinson’s disease: From genetic to clinic to new therapeutic approaches. Cells. 8 (4), 364. https://doi.org/10.3390/cells8040364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Q., Ganesan D. 2022. Regulation of neuronal autophagy and the implications in neurodegenerative diseases. Neurobiol. Dis. 162, 105582. https://doi.org/10.1016/j.nbd.2021.105582

Article  CAS  PubMed  Google Scholar 

Rubinsztein D.C., Codogno P., Levine B. 2012. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discovery. 11 (9), 709‒730. https://doi.org/10.1038/nrd3802

Article  CAS  PubMed  Google Scholar 

Menzies F.M., Fleming A., Caricasole A., Bento C.F., Andrews S.P., Ashkenazi A., Füllgrabe J., Jackson A., Jimenez Sanchez M., Karabiyik C., Licitra F., Lopez Ramirez A., Pavel M., Puri C., Renna M., Ricketts T., Schlotawa L., Vicinanza M., Won H., Zhu Y., Skidmore J., Rubinsztein D.C. 2017. Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities. Neuron. 93 (5), 1015‒1034. https://doi.org/10.1016/j.neuron.2017.01.022

Article  CAS  PubMed  Google Scholar 

Hubert V., Weiss S., Rees A.J., Kain R. 2022. Modulating chaperone-mediated autophagy and its clinical applications in cancer. Cells. 11 (16), 2562. https://doi.org/10.3390/cells11162562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bandyopadhyay U., Cuervo A.M. 2008. Entering the lysosome through a transient gate by chaperone-mediated autophagy. Autophagy. 4 (8), 1101–1103. https://doi.org/10.4161/auto.7150

Article  CAS  PubMed  Google Scholar 

Rout A.K., Strub M.P., Piszczek G., Tjandra N. 2014. Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP‒2A) reveals key features for substrate specificity in chaperone-mediated autophagy. J. Biol. Chem. 289 (51), 35111‒35123. https://doi.org/10.1074/jbc.M114.609446

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuervo A.M., Wong E. 2014. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 24 (1), 92‒104. https://doi.org/10.1038/cr.2013.153

Article  CAS  PubMed  Google Scholar 

Cuervo A.M., Dice J.F. 2000. Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 24, 4441‒4450. https://doi.org/10.1242/jcs.113.24.444

Article  Google Scholar 

Fellner L., Gabassi E., Haybaeck J., Edenhofer F. 2021. Autophagy in α-synucleinopathies‒an overstrained system. Cells. 10 (11), 3143. https://doi.org/10.3390/cells10113143

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuervo A.M., Stafanis L., Fredenburg R., Lansbury P.T., Sulzer D. 2004. Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy. Science. 305 (5688), 1292‒1295. https://doi.org/10.1126/science.1101738

Article  CAS  PubMed  Google Scholar 

Yim W.W., Mizushima N. 2020. Lysosome biology in autophagy. Cell Discovery. 6, 6. https://doi.org/10.1038/s41421-020-0141-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mijaljica D., Prescott M., Devenish R.J. 2011. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy. 7 (7), 673‒682. https://doi.org/10.4161/auto.7.7.14733

Article  CAS  PubMed  Google Scholar 

Xicoy H., Peñuelas N., Vila M., Laguna A. 2019. Autophagic- and lysosomal-related biomarkers for Parkinson’s disease: Lights and shadows. Cells. 8 (11), 1317. https://doi.org/10.3390/cells8111317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ylä‒Anttila P., Vihinen H., Jokitalo E., Eskelinen E.L. 2009. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy. 5 (8), 1180‒1185. https://doi.org/10.4161/auto.5.8.10274

Article  PubMed  Google Scholar 

Yamamoto Y.H., Noda T. 2020. Autophagosome formation in relation to the endoplasmic reticulum. J. Biomed. Sci. 27 (1), 97. https://doi.org/10.1186/s12929-020-00691-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamasaki M., Furuta N., Matsuda A., Nezu A., Yamamoto A., Fujita N., Oomori H., Noda T., Haraguchi T., Hiraoka Y., Amano A., Yoshimori T. 2013. Autophagosomes form at ER‒mitochondria contact sites. Nature. 495 (7441), 389‒393. https://doi.org/10.1038/nature11910

Article  CAS  PubMed  Google Scholar 

Ganesan D., Cai Q. 2021. Understanding amphisomes. Biochem. J. 478 (10), 1959–1976. https://doi.org/10.1042/BCJ20200917

Article  CAS  PubMed  Google Scholar 

Ravikumar B., Moreau K., Jahreiss L., Puri C., Rubinsztein D.C. 2010. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat. Cell. Biol. 12 (8), 747‒757. https://doi.org/10.1038/ncb2078

Article  CAS  PubMed  PubMed Central  Google Scholar 

H

Comments (0)

No login
gif