Bit1 promotes the progression of gastric cancer by facilitating epithelial–mesenchymal transition and alleviating apoptosis

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics. CA Cancer J Clin. 2024;74(2024):12–49.

Article  PubMed  Google Scholar 

Thrift AP, Wenker TN, El-Serag HB. Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol. 2023;20:338–49.

Article  PubMed  Google Scholar 

Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019;7:509–22.

Article  PubMed  PubMed Central  Google Scholar 

Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020;396:635–48.

Article  CAS  PubMed  Google Scholar 

Sonkin D, Thomas A, Teicher BA. Cancer treatments: past, present, and future. Cancer Genet. 2024;286–287:18–24.

Article  PubMed  Google Scholar 

Hu J, Yu W, Dai Y, Liu C, Wang Y, Wu Q. A deep neural network for gastric cancer prognosis prediction based on biological information pathways. J Oncol. 2022;2022:2965166.

Article  PubMed  PubMed Central  Google Scholar 

Stupack DG, Cheresh DA. A Bit-role for integrins in apoptosis. Nat Cell Biol. 2004;6:388–9.

Article  CAS  PubMed  Google Scholar 

Corpuz AD, Ramos JW, Matter ML. PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation. Cell Death Discov. 2020;6:124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao X, Gray S, Pham T, Delgardo M, Nguyen A, Do S, Ireland SK, Chen R, Abdel-Mageed AB, Biliran H. Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin. Biochem Biophys Res Commun. 2018;495:1240–8.

Article  CAS  PubMed  Google Scholar 

Yao X, Jennings S, Ireland SK, Pham T, Temple B, Davis M, Chen R, Davenport I, Biliran H. The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells. PLoS ONE. 2014;9: e101564.

Article  PubMed  PubMed Central  Google Scholar 

Zheng J, Zhou J, Xie X, Xie B, Lin J, Xu Z, Zhang W. Estrogen decreases anoikis of ovarian cancer cell line Caov-3 through reducing release of Bit1. DNA Cell Biol. 2014;33:847–53.

Article  CAS  PubMed  Google Scholar 

Xiao Y, Yang Y, Wang J, Li W. Bit1 regulates cell migration and survival in oral squamous cell carcinoma. J Oral Maxillofac Surg. 2017:S0278239117303452.

Chen J, Liu H, Gao P, Hui Y, Yang Z, Zhang X, Xu P, Tian F, Fan T. Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus. Tumour Biol. 2017;39:1010428317708267.

PubMed  Google Scholar 

Wang Z, Yin M, Wang R, Liu X, Yan D. Bit1 silencing enhances the proliferation, migration, and invasion of glioma cells through activation of the IL-6/STAT3 pathway. Onco Targets Ther. 2020;13:2469–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan T, Chen J, Zhang L, Gao P, Hui Y, Xu P, Zhang X, Liu H. Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Mol Cancer. 2016;15:23.

Article  PubMed  PubMed Central  Google Scholar 

Nandakumar N, Gopinath P, Gopas J, Muraleedharan KM. Benzisothiazolone derivatives exhibit cytotoxicity in hodgkin’s lymphoma cells through NF-kappaB inhibition and are synergistic with doxorubicin and etoposide. Anticancer Agents Med Chem. 2020;20:715–23.

Article  CAS  PubMed  Google Scholar 

Covarrubias AA, Reyna-Jeldes M, Pedroso-Santana S, Marín S, Madero-Mendoza C, Demergasso C, Coddou C. Arsenic nanoparticles trigger apoptosis via anoikis induction in OECM-1 cells. In J Mol Sci. 2024;25:6723.

Article  CAS  Google Scholar 

Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29:212–26.

Article  CAS  PubMed  Google Scholar 

Park E, Kim SW, Kim S, Kim HS, Lee JY, Kim YT, Cho NH. Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix. Mod Pathol. 2021;34:637–46.

Article  CAS  PubMed  Google Scholar 

Abbas A, Jun P, Yuan JY, Sun L, Jiang J, Yuan S. Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers. Basic Clin Pharmacol Toxicol. 2022;131:241–50.

Article  CAS  PubMed  Google Scholar 

Mahalanobish S, Saha S, Dutta S, Sil PC. Matrix metalloproteinase: an upcoming therapeutic approach for idiopathic pulmonary fibrosis. Pharmacol Res. 2020;152: 104591.

Article  CAS  PubMed  Google Scholar 

Piperigkou Z, Manou D, Karamanou K, Theocharis AD. Strategies to target matrix metalloproteinases as therapeutic approach in cancer. Methods Mol Biol. 2018;1731:325–48.

Article  CAS  PubMed  Google Scholar 

Turunen SP, Tatti-Bugaeva O, Lehti K. Membrane-type matrix metalloproteases as diverse effectors of cancer progression. Biochim Biophys Acta Mol Cell Res. 1864;2017:1974–88.

Google Scholar 

Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T. Extracellular vesicles from cancer-associated fibroblasts containing annexin A6 Induces FAK-YAP activation by stabilizing beta1 integrin, enhancing drug resistance. Cancer Res. 2020;80:3222–35.

Article  CAS  PubMed  Google Scholar 

Oria VO, Lopatta P, Schilling O. The pleiotropic roles of ADAM9 in the biology of solid tumors. Cell Mol Life Sci. 2018;75:2291–301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma B, Ni N, Shao W, Xu J, Ji J, Luo M. Bit1 is involved in regulation between integrin and TGFbeta signaling in lens epithelial cells. Cell Cycle. 2022;21:2283–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dattachoudhury S, Sharma R, Kumar A, Jaganathan BG. Sorafenib inhibits proliferation, migration and invasion of breast cancer cells. Oncology. 2020;98:478–86.

Article  CAS  PubMed  Google Scholar 

Kang ZR, Jiang S, Han JX, Gao Y, Xie Y, Chen J, Liu Q, Yu J, Zhao X, Hong J, Chen H, Chen YX, Chen H, Fang JY. Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development. Biochim Biophys Acta Mol Basis Dis. 2024;1870: 166941.

Article  CAS  PubMed  Google Scholar 

Lee SJ, Jeon SH, Cho S, Kim CM, Yoo JK, Oh SH, Kim JH, Yang YD, Kim JK. hsa-miR-CHA2, a novel microRNA, exhibits anticancer effects by suppressing cyclin E1 in human non-small cell lung cancer cells. Biochim Biophys Acta Mol Basis Dis. 2024;1870: 167250.

Article  CAS  PubMed  Google Scholar 

Abadi AJ, Zarrabi A, Hashemi F, Zabolian A, Najafi M, Entezari M, Hushmandi K, Aref AR, Khan H, Makvandi P, Ashrafizaveh S, Farkhondeh T, Ashrafizadeh M, Samarghandian S, Hamblin MR. The role of SOX family transcription factors in gastric cancer. Int J Biol Macromol. 2021;180:608–24.

Article  CAS  PubMed  Google Scholar 

Zhang M, Zhang B. Extracellular matrix stiffness: mechanisms in tumor progression and therapeutic potential in cancer. Exp Hematol Oncol. 2025;14:54.

Article  PubMed  PubMed Central  Google Scholar 

Yao X, Pham T, Temple B, Gray S, Cannon C, Chen R, Abdel-Mageed AB, Biliran H. The anoikis effector Bit1 inhibits EMT through attenuation of TLE1-mediated repression of E-cadherin in lung cancer cells. PLoS ONE. 2016;11: e0163228.

Article 

Comments (0)

No login
gif