Andreadou I, Sigala F, Iliodromitis EK, Papaefthimiou M, Sigalas C, Aligiannis N, Savvari P, Gorgoulis V, Papalabros E, Kremastinos DT (2007) Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. J Mol Cell Cardiol 42(3):549–558
Article CAS PubMed Google Scholar
Barary M, Hosseinzadeh R, Kazemi S, Liang JJ, Mansoori R, Sio TT, Hosseini M, Moghadamnia AA (2022) The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats. Sci Rep 12(1):8661
Article CAS PubMed PubMed Central Google Scholar
Barchowsky A, Frleta D, Vincenti MP (2000) Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12(10):1469–1479
Article CAS PubMed Google Scholar
Boss A, Bishop KS, Marlow G, Barnett MP, Ferguson LR (2016) Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients 8(8):513
Article PubMed PubMed Central Google Scholar
Canale ML, Camerini A, Stroppa S, Porta RP, Caravelli P, Mariani M, Balbarini A, Ricci S (2006) A case of acute myocardial infarction during 5-fluorouracil infusion. J Cardiovasc Med (Hagerstown) 7(11):835–837
Castejón ML, Rosillo M, Montoya T, González-Benjumea A, Fernández-Bolaños JG, Alarcón-de-la-Lastra C (2017) Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982. Food Funct 8(5):1890–1898
Chan AK, Choo BA, Glaholm J (2011) Pulmonary toxicity with oxaliplatin and capecitabine/5-fluorouracil chemotherapy: a case report and review of the literature. Onkologie 34(8–9):443–446
De Forni M, Malet-Martino MC, Jaillais P, Shubinski RE, Bachaud JM, Lemaire L, Canal P, Chevreau C, Carrié D, Soulié P et al (1992) Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study. J Clin Oncol 10(11):1795–1801
Diba M, Seghatoleslam A, Namavari M, Assadi S, Vakili SN, Babaei Z, Akmali M (2021) Potential protective role of cyrtopodion scabrum in antioxidant parameters in serum and liver of rats with 5-fu-induced oxidative damage. Arch Razi Inst 76(1):95–105
CAS PubMed PubMed Central Google Scholar
Dikmen N, Cellat M, Etyemez M, İşler CT, Uyar A, Aydın T, Güvenç M (2021) Ameliorative effects of oleuropein on lipopolysaccharide-induced acute lung injury model in rats. Inflammation 44(6):2246–2259
Article CAS PubMed Google Scholar
Dyhl-Polk A, Schou M, Vistisen KK, Sillesen AS, Serup-Hansen E, Faber J, Klausen TW, Bojesen SE, Vaage-Nilsen M, Nielsen DL (2021) Myocardial ischemia induced by 5-fluorouracil: a prospective electrocardiographic and cardiac biomarker study. Oncologist 26(3):e403–e413
Article CAS PubMed Google Scholar
Geyikoglu F, Emir M, Colak S, Koc K, Turkez H, Bakir M, Hosseinigouzdagani M, Cerig S, Keles ON, Ozek NS (2017a) Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury. J Food Drug Anal 25(2):447–459
Article CAS PubMed Google Scholar
Geyikoglu F, Isikgoz H, Onalan H, Colak S, Cerig S, Bakir M, Hosseinigouzdagani M, Koc K, Erol HS, Saglam YS, Yildirim S (2017b) Impact of high-dose oleuropein on cisplatin-induced oxidative stress, genotoxicity and pathological changes in rat stomach and lung. J Asian Nat Prod Res 19(12):1214–1231
Article CAS PubMed Google Scholar
Golmohammadi MG, Banaei S, Timar M, Abedi A (2023) Saponin protects against cyclophosphamide-induced kidney and liver damage via antioxidant and anti-inflammatory actions. Physiol Int 110(2):108–120
Article CAS PubMed Google Scholar
González P, Lozano P, Ros G, Solano F (2023) Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci 24(11):9352
Article PubMed PubMed Central Google Scholar
Gorzynik-Debicka M, Przychodzen P, Cappello F, Kuban-Jankowska A, Marino Gammazza A, Knap N, Wozniak M, Gorska-Ponikowska M (2018) Potential health benefits of olive oil and plant polyphenols. Int J Mol Sci 19(3):686
Article PubMed PubMed Central Google Scholar
Gowda S, Desai PB, Hull VV, Avinash AK, Vernekar SN, Kulkarni SS (2009) A review on laboratory liver function tests. Pan Afr Med J 3:17
PubMed PubMed Central Google Scholar
Huang S, Lin Y, Liang Z, Wu Z, Chen Y, Chen C (2019) Erythropoietin helix B surface peptide modulates miR-21/Atg12 axis to alleviates cardiomyocyte hypoxia-reoxygenation injury. Am J Transl Res 11(4):2422–2430
CAS PubMed PubMed Central Google Scholar
Idriss HT, Naismith JH (2000) TNFα and the TNF receptor superfamily: structure-function relationship (s). Microsc Res Tech 50(3):184–195
Article CAS PubMed Google Scholar
Janahmadi Z, Nekooeian AA, Moaref AR, Emamghoreishi M (2017) Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects. Naunyn Schmiedebergs Arch Pharmacol 390(3):245–252
Article CAS PubMed Google Scholar
Khalatbary AR, Zarrinjoei GR (2012) Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iran Red Crescent Med J 14(4):229–234
CAS PubMed PubMed Central Google Scholar
Lee W, Song G, Bae H (2022) Matairesinol induces mitochondrial dysfunction and exerts synergistic anticancer effects with 5-fluorouracil in pancreatic cancer cells. Mar Drugs 20(8):473
Article CAS PubMed PubMed Central Google Scholar
Longley DB, Harkin DP, Johnston PG (2003) 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3(5):330–338
Article CAS PubMed Google Scholar
Menezes RCR, Peres KK, Costa-Valle MT, Faccioli LS, Dallegrave E, Garavaglia J, Dal Bosco SM (2022) Oral administration of oleuropein and olive leaf extract has cardioprotective effects in rodents: a systematic review. Rev Port Cardiol 41(2):167–175
Mishra T, Shokr M, Ahmed A, Afonso L (2019) Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug. BMJ Case Rep 12(9):e230499
Article PubMed PubMed Central Google Scholar
Nasrallah H, Aissa I, Slim C, Boujbiha MA, Zaouali MA, Bejaoui M, Wilke V, Ben Jannet H, Mosbah H, Ben Abdennebi H (2020) Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Life Sci 255:117833
Article CAS PubMed Google Scholar
Omar SH (2010) Oleuropein in olive and its pharmacological effects. Sci Pharm 78(2):133–154
Article CAS PubMed PubMed Central Google Scholar
Ozawa Y, Akahori D, Koda K, Abe T, Hasegawa H, Matsui T, Tanahashi M, Niwa H, Yamada K, Yokomura K, Suda T (2016) Distinctive impact of pre-existing interstitial lung disease on the risk of chemotherapy-related lung injury in patients with lung cancer. Cancer Chemother Pharmacol 77(5):1031–1038
Article CAS PubMed Google Scholar
Pojero F, Aiello A, Gervasi F, Caruso C, Ligotti ME, Calabrò A, Procopio A, Candore G, Accardi G, Allegra M (2022) Effects of oleuropein and hydroxytyrosol on inflammatory mediators: consequences on inflammaging. Int J Mol Sci 24(1):380
Article PubMed PubMed Central Google Scholar
Qabaha K, Al-Rimawi F, Qasem A, Naser SA (2018) Oleuropein is responsible for the major anti-inflammatory effects of olive leaf extract. J Med Food 21(3):302–305
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