Comparative potentiating effects of remimazolam, propofol and sevoflurane on rocuronium-induced neuromuscular block: a randomized controlled trial

Kim KM. Remimazolam: pharmacological characteristics and clinical applications in anesthesiology. Anesth Pain Med (Seoul). 2022;17:1–11.

Article  PubMed  CAS  Google Scholar 

Hu Q, Liu X, Wen C, Li D, Lei X. Remimazolam: an updated review of a new sedative and anaesthetic. Drug Des Devel Ther. 2022;16:3957–74.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peck J, Urits I, Crane J, McNally A, Noor N, Patel M, Berger AA, Cornett EM, Kassem H, Kaye AD, Viswanath O. Oral muscle relaxants for the treatment of chronic pain associated with cerebral palsy. Psychopharmacol Bull. 2020;50:142–62.

PubMed  PubMed Central  Google Scholar 

Sanger DJ, Benavides J, Perrault G, Morel E, Cohen C, Joly D, Zivkovic B. Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes. Neurosci Biobehav Rev. 1994;18:355–72.

Article  PubMed  CAS  Google Scholar 

Suzuki T, Munakata K, Watanabe N, Katsumata N, Saeki S, Ogawa S. Augmentation of vecuronium-induced neuromuscular block during sevoflurane anaesthesia: comparison with balanced anaesthesia using propofol or midazolam. Br J Anaesth. 1999;83:485–7.

Article  PubMed  CAS  Google Scholar 

Lowry DW, Mirakhur RK, McCarthy GJ, Carroll MT, McCourt KC. Neuromuscular effects of rocuronium during sevoflurane, isoflurane, and intravenous anesthesia. Anesth Analg. 1998;87:936–40.

Article  PubMed  CAS  Google Scholar 

Takagi S, Kitajima O, Yamamoto M, Matsui M, Suzuki T. Potentiation by sevoflurane of rocuronium-induced neuromuscular block is greater in older than younger adult patients: a randomised controlled trial. Br J Anaesth. 2020;125:351–3.

Article  Google Scholar 

Fuchs-Buder T, Brull SJ, Fagerlund MJ, Renew JR, Cammu G, Murphy GS, Warlé M, Vested M, Fülesdi B, Nemes R, Columb MO, Damian D, Davis PJ, Iwasaki H, Eriksson LI. Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents III: The 2023 Geneva revision. Acta Anaesthesiol Scand. 2023;67:994–1017.

Article  PubMed  CAS  Google Scholar 

Brull SJ, Silverman DG. Tetanus-induced changes in apparent recovery after bolus doses of atracurium or vecuronium. Anesthesiology. 1992;77:642–5.

Article  PubMed  CAS  Google Scholar 

Sato H, Iwasaki H, Doshu-Kajiura A, Katagiri S, Takagi S, Luthe SK, Suzuki T. Comparison of two electromyography-based neuromuscular monitors, AF-201P and TetraGraph, in rocuronium-induced neuromuscular block: a prospective comparative study. Anaesth Crit Care Pain Med. 2022;41: 101145.

Article  PubMed  Google Scholar 

Kanda Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

Article  PubMed  CAS  Google Scholar 

Driessen JJ, Crul JF, Vree TB, Egmond J, Booij LH. Benzodiazepines and neuromuscular blocking drugs in patients. Acta Anaesthesiol Scand. 1986;30:642–6.

Article  PubMed  CAS  Google Scholar 

Driessen JJ, Vree TB, Egmond JV, Booij LH, Crul JF. Interaction of midazolam with two non-depolarizing neuromuscular blocking drugs in the rat in vivo sciatic nerve-tibialis anterior muscle preparation. Br J Anaesth. 1985;57:1089–94.

Article  PubMed  CAS  Google Scholar 

Narimatsu E, Niiya T, Kawamata M, Namiki A. Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms. Anaesthesiol Scand. 2008;52:1415–22.

Article  CAS  Google Scholar 

Todd KJ, Robitaille R. Purinergic modulation of synaptic signalling at the neuromuscular junction. Pflugers Arch. 2006;452:608–14.

Article  PubMed  CAS  Google Scholar 

Correia-de-Sá P, Sebastião AM, Ribeiro JA. Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve ending of the rat. Br J Pharmacol. 1991;103:1614–20.

Article  PubMed  PubMed Central  Google Scholar 

Sakata H, Ishikawa Y, Ishihara G, Oyama N, Itami T, Umar MA, Sano T, Yamashita K. Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs. J Vet Med Sci. 2019;81:425–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Suzuki T, Iwasaki K, Fukano N, Hariya S, Saeki S, Ogawa S. Duration of exposure to sevoflurane affects dose-response relationship of vecuronium. Br J Anaesth. 2000;85:732–4.

Article  PubMed  CAS  Google Scholar 

Ezzine S, Yamaguchi N, Varin F. Determination of interstitial rocuronium concentrations in the muscle tissue of anesthetized dogs by microdialysis. J Pharmacol Toxicol Methods. 2004;49:121–9.

Article  PubMed  CAS  Google Scholar 

Ishii-Maruhama M, Higuchi H, Nakanou M, Honda-Wakasugi Y, Yabuki-Kawase A, Maeda S, Honda-Wakasugi Y, Yabuki-Kawase A, Maeda S, Miyawaki T. In vitro changes in the proportion of protein-unbound-free propofol induced by valproate. J Anesth. 2018;32:688–93.

Article  PubMed  Google Scholar 

Gray HS, Slater RM, Pollard BJ. The effect of acutely administered phenytoin on vecuronium-induced neuromuscular blockade. Anaesthesia. 1989;44:379–81.

Article  PubMed  CAS  Google Scholar 

Spacek A, Nickl S, Neiger FX, Nigrovic V, Ullrich OW, Weindmayr-Goettel M, Schwall B, Taeger K, Kress HG. Augmentation of the rocuronium-induced neuromuscular block by the acutely administered phenytoin. Anesthesiology. 1999;90:1551–5.

Article  PubMed  CAS  Google Scholar 

Comments (0)

No login
gif