Myofibroblastoma is a rare, benign mesenchymal tumor typically found in the breast. Its occurrence in the genital region, particularly in the clitoris, is exceedingly uncommon, with very few reported cases in the literature. Given its rarity, clitoral myofibroblastoma can present significant diagnostic and therapeutic challenges due to its similarity to more aggressive tumors, including sarcomas. Here, we present a rare case of clitoral myofibroblastoma, discussing its clinical presentation, diagnosis, and management.

Clitoral myofibroblastoma, while benign, poses diagnostic challenges due to its rarity and similarity to malignant lesions like sarcomas. Preoperative imaging may not always provide a definitive diagnosis, necessitating histological confirmation. Immunohistochemistry plays a crucial role in distinguishing this tumor from other spindle cell neoplasms.

This case highlights the importance of considering myofibroblastoma in the differential diagnosis of clitoral masses. Accurate diagnosis through histopathology and immunohistochemistry is essential to guide appropriate management. Awareness of this rare entity is crucial for gynecologists and oncologists to avoid overtreatment of this benign tumor.