Evaluation of Genes and Molecular Pathways Involved in the Switch of Endometriosis to Ovarian Cancer: A Systems Biology Approach

Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022;379:e070750.

Article  PubMed  Google Scholar 

Signorile PG, Viceconte R, Baldi A. New insights in pathogenesis of endometriosis. Front Med. 2022;9: 879015.

Article  Google Scholar 

Nijkang NP, Anderson L, Markham R, Manconi F. Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Med. 2019;7:2050312119848247.

Article  PubMed  PubMed Central  Google Scholar 

Babadi AJ, Kouti RN, Zeinali M, Lordejani MA, Marandi HJ, Farhadi E. Effect of Cervical Index changes on cervical pain. J Iran Med Counc. 2024.

Casalechi M, Tripodi A, Reis FM, Carullo G, Mondini I, Di Stefano G, et al. The link between inflammation and hemostasis in endometriosis: a call for research. J Endometr Uterine Disorders. 2023;3: 100040.

Article  Google Scholar 

Herreros-Villanueva M, Chen C-C, Tsai E-M, Er T-K. Endometriosis-associated ovarian cancer: What have we learned so far? Clin Chim Acta. 2019;493:63–72.

Article  CAS  PubMed  Google Scholar 

So KA, Hong SR, Kim NR, Yang EJ, Shim S-H, Lee SJ, et al. Association between atypical endometriosis and ovarian malignancies in the real world. J Ovarian Res. 2021;14(1):110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee HJ, Lee B, Choi H, Kim T, Kim Y, Kim YB. Impact of hormone replacement therapy on risk of ovarian cancer in postmenopausal women with de novo endometriosis or a history of endometriosis. Cancers (Basel). 2023;15(6):1708.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murakami K, Kotani Y, Nakai H, Matsumura N. Endometriosis-associated ovarian cancer: the origin and targeted therapy. Cancers. 2020;12(6):1676.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yachida N, Yoshihara K, Yamaguchi M, Suda K, Tamura R, Enomoto T. How does endometriosis lead to ovarian cancer? The molecular mechanism of endometriosis-associated ovarian cancer development. Cancers. 2021;13(6):1439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdulwahid A-HRR, Mahdi MH, Amiri BS, Koosehlar E, Kazemi N, Ghiasi F, et al. In silico analysis of genes and molecular pathways involved in the pathogenesis of follicular lymphoma. Iran J Pediatric Hematol Oncol. 2024.

Teng YH, Liu FC, Huang SY, Kuo CF, Yu HP. Epidemiology and mortality of ovarian cancer in Taiwan: a population-based study. J Clin Med. 2022;11(19):5627.

Article  PubMed  PubMed Central  Google Scholar 

Wang W, Cho U, Yoo A, Jung C-L, Kim B, Kim H, et al. Wnt/β-Catenin inhibition by CWP232291 as a novel therapeutic strategy in ovarian cancer. Front Oncol. 2022;12: 852260.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laganà AS, Garzon S, Götte M, Viganò P, Franchi M, Ghezzi F, et al. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci. 2019;20(22):5615.

Article  PubMed  PubMed Central  Google Scholar 

Kabacaoglu D, Ruess DA, Ai J, Algül H. NF-κB/Rel transcription factors in pancreatic cancer: focusing on RelA, c-Rel, and RelB. Cancers. 2019;11(7):937.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jinawath N, Vasoontara C, Jinawath A, Fang X, Zhao K, Yap K-L, et al. Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma. PLoS ONE. 2010;5(6): e11198.

Article  PubMed  PubMed Central  Google Scholar 

Asghari S, Valizadeh Dizajeykan A, Ahmadi M, Barzegari A, Rikhtegar R, Dolati S, et al. Evaluation of ovarian cancer risk in granulosa cells treated with steroid-depleted endometriosis serum: Role of NF-κB/RelA and AKT. J Cell Physiol. 2019;234(7):12011–8.

Article  CAS  PubMed  Google Scholar 

Marla S, Mortlock S, Houshdaran S, Fung J, McKinnon B, Holdsworth-Carson S, et al. Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. Mol Hum Reprod. 2021;27(1):gaaa082.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Wang J, Zhang X. An update on the multifaceted role of NF-kappaB in endometriosis. Int J Biol Sci. 2022;18(11):4400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emami M, Shafie D, Vakhshoori M, Eghbali-Babadi M, Ahmadipour E, Khosravi A. Evaluation of the efficiency of indirect blood pressure measurement methods in comparison to intra-arterial reading among Iranian individuals. Int Cardiovasc Res J. 2020;14(3).

Aléssio AM, Höehr NF, Siqueira LH, Ozelo MC, de Pádua MA, Annichino-Bizzacchi JM. Association between estrogen receptor alpha and beta gene polymorphisms and deep vein thrombosis. Thromb Res. 2007;120(5):639–45.

Article  PubMed  Google Scholar 

Yu X, Zhao QY, Yaman M, Emly SM, Lee JK, Su H, et al. Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish. bioRxiv. 2024:2024.11.13.623199.

Guo T, Dong X, Xie S, Zhang L, Zeng P, Zhang L. Cellular mechanism of gene mutations and potential therapeutic targets in ovarian cancer. Cancer Manag Res. 2021;2021:3081–100.

Article  Google Scholar 

Ghoneum A, Abdulfattah AY, Said N. Targeting the PI3K/AKT/mTOR/NFκB axis in ovarian cancer. J Cellul Immunol. 2020;2(2):68.

Google Scholar 

Wu M, Zhang Y. MiR-182 inhibits proliferation, migration, invasion and inflammation of endometrial stromal cells through deactivation of NF-κB signaling pathway in endometriosis. Mol Cell Biochem. 2021;476:1575–88.

Article  CAS  PubMed  Google Scholar 

Qiu L, Wang J, Chen M, Chen F, Tu W. Exosomal microRNA-146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2-mediated PI3K/Akt axis. Int J Mol Med. 2020;46(2):609–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bischof K, Knappskog S, Hjelle SM, Stefansson I, Woie K, Salvesen HB, et al. Influence of p53 isoform expression on survival in high-grade serous ovarian cancers. Sci Rep. 2019;9(1):5244.

Article  PubMed  PubMed Central  Google Scholar 

Huang H, Chen AY, Ye X, Guan R, Rankin GO, Chen YC. Galangin, a flavonoid from lesser galangal, induced apoptosis via p53-dependent pathway in ovarian cancer cells. Molecules. 2020;25(7):1579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen VHL, Hough R, Bernaudo S, Peng C. Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis. J Ovarian Res. 2019;12:1–17.

Article  Google Scholar 

Ishizaka A, Taguchi A, Tsuruga T, Maruyama M, Kawata A, Miyamoto Y, et al. Endometrial cancer with concomitant endometriosis is highly associated with ovarian endometrioid carcinoma: a retrospective cohort study. BMC Womens Health. 2022;22(1):332.

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Zhang J, Liu X, Wei B, Zhan L. Long noncoding RNAs in endometriosis: biological functions, expressions, and mechanisms. J Cell Physiol. 2021;236(1):6–14.

Article  CAS  PubMed  Google Scholar 

Rad HF, Karimi MS, Behfar M, Nazari A, Hassani N, Hasanvand A, et al. LncRNA Linc00261 sponge’s miR-33-regulated PI3-kinase in autism disorder. Gene Reports. 2025;38: 102115.

Article  CAS  Google Scholar 

Han O, Alci A, Yildirim HT, Gokkaya M, Yalcin N, Kandemir S, et al. β-catenin expression in endometrioid type endometrial cancer: expression patterns and impact on disease outcomes. Oncol Lett. 2024;28(6):580.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Nie X-B, Liu S-J, Liu J, Bian W-H. Curcumol attenuates endometriosis by inhibiting the JAK2/STAT3 signaling pathway. Med Sci Monitor Int Med J Exp Clin Res. 2022;28:e934914–21.

CAS  Google Scholar 

Adereh A, Amini P, Fateh A, Faghihkhorasani F, Khdakarim N, Marashi SM, et al. Loc646329 sponges miR-21 to reduce RAS/MAP kinase signaling pathway in oral squamous cell carcinoma (OSCC). Naunyn-Schmiedeberg's Arch Pharmacol. 2024:1–9.

Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y, et al. STAT3 signaling in ovarian cancer: a potential therapeutic target. J Cancer. 2020;11(4):837.

Article  CAS  PubMed 

Comments (0)

No login
gif