Baskin DG, Wilcox BJ, Figlewicz DP, Dorsa DM (1988) Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11:107–111. https://doi.org/10.1016/0166-2236(88)90155-5

Article  PubMed  CAS  Google Scholar 

Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P (2001) Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410:376–380. https://doi.org/10.1038/35066591

Article  PubMed  CAS  Google Scholar 

Chen WN, Yeong KY (2020) Scopolamine, a toxin-induced experimental model, used for research in Alzheimer’s disease. CNS Neurol Disord Drug Targets 19:85–93. https://doi.org/10.2174/1871527319666200214104331

Article  PubMed  CAS  Google Scholar 

Chen X, Wang M, Xu X, Liu J, Mei B, Fu P, Zhao D, Sun L (2017) Panax ginseng total protein promotes proliferation and secretion of collagen in NIH/3T3 cells by activating extracellular signal-related kinase pathway. J Ginseng Res 41:411–418. https://doi.org/10.1016/j.jgr.2017.02.001

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Li H, Yang Q, Lan X, Wang J, Cao Z, Shi X, Li J, Kan M, Qu X, Li N (2019) Ginsenoside compound K ameliorates Alzheimer’s disease in HT22 cells by adjusting energy metabolism. Mol Biol Rep 46:5323–5332. https://doi.org/10.1007/s11033-019-04988-0

Article  PubMed  CAS  Google Scholar 

Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701–712. https://doi.org/10.1038/nrn3346

Article  PubMed  CAS  Google Scholar 

Cryan JF, O’Mahony SM (2011) The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil 23:187–192. https://doi.org/10.1111/j.1365-2982.2010.01664.x

Article  PubMed  CAS  Google Scholar 

Di Giacomo E, Benedetti E, Cristiano L, Antonosante A, d’Angelo M, Fidoamore A, Barone D, Moreno S, Ippoliti R, Cerù MP, Giordano A, Cimini A (2017) Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis. Cell Cycle 16:59–72. https://doi.org/10.1080/15384101.2016.1252881

Article  PubMed  CAS  Google Scholar 

Diaz Heijtz R, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A 108:3047–3052. https://doi.org/10.1073/pnas.1010529108

Article  PubMed  Google Scholar 

Dienel GA (2019) Brain glucose metabolism: integration of energetics with function. Physiol Rev 99:949–1045. https://doi.org/10.1152/physrev.00062.2017

Article  PubMed  CAS  Google Scholar 

Doulberis M, Kotronis G, Thomann R, Polyzos SA, Boziki M, Gialamprinou D, Deretzi G, Katsinelos P, Kountouras J (2018) Review: impact of helicobacter pylori on Alzheimer’s disease: what do we know so far? Helicobacter 23. https://doi.org/10.1111/hel.12454

Ellekilde M, Krych L, Hansen CH, Hufeldt MR, Dahl K, Hansen LH, Sørensen SJ, Vogensen FK, Nielsen DS, Hansen AK (2014) Characterization of the gut microbiota in leptin deficient obese mice - correlation to inflammatory and diabetic parameters. Res Vet Sci 96:241–250. https://doi.org/10.1016/j.rvsc.2014.01.007

Article  PubMed  CAS  Google Scholar 

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 100:4162–4167. https://doi.org/10.1073/pnas.0230450100

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fischer A, Sananbenesi F, Schrick C, Spiess J, Radulovic J (2002) Cyclin-dependent kinase 5 is required for associative learning. J Neurosci 22:3700–3707. https://doi.org/10.1523/jneurosci.22-09-03700.2002

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao L, Li J, Zhou Y, Huang X, Qin X, Du G (2018) Effects of Baicalein on cortical proinflammatory cytokines and the intestinal Microbiome in senescence accelerated mouse prone 8. ACS Chem Neurosci 9:1714–1724. https://doi.org/10.1021/acschemneuro.8b00074

Article  PubMed  CAS  Google Scholar 

Graham WV, Bonito-Oliva A, Sakmar TP (2017) Update on Alzheimer’s disease therapy and prevention strategies. Annu Rev Med 68:413–430. https://doi.org/10.1146/annurev-med-042915-103753

Article  PubMed  CAS  Google Scholar 

Gupte M, Tousif S, Lemon JJ, Toro Cora A, Umbarkar P, Lal H (2022) Isoform-specific role of GSK-3 in high fat diet induced obesity and glucose intolerance. Cells, p 11. https://doi.org/10.3390/cells11030559

Book  Google Scholar 

Han Y, Wang J, Zhao Q, Xie X, Song R, Xiao Y, Kang X, Zhang L, Zhang Y, Peng C, You Z (2020) Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain Behav Immun 87:568–78. https://doi.org/10.1016/j.bbi.2020.02.002

Article  PubMed  CAS  Google Scholar 

Havrankova J, Schmechel D, Roth J, Brownstein M (1978) Identification of insulin in rat brain. Proc Natl Acad Sci U S A 75:5737–5741. https://doi.org/10.1073/pnas.75.11.5737

Article  PubMed  PubMed Central  CAS  Google Scholar 

Heneka MT, Klockgether T, Feinstein DL (2000) Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J Neurosci 20:6862–6867. https://doi.org/10.1523/jneurosci.20-18-06862.2000

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hill JM, Bhattacharjee S, Pogue AI, Lukiw WJ (2014) The gastrointestinal tract microbiome and potential link to Alzheimer’s disease. Front Neurol 5:43. https://doi.org/10.3389/fneur.2014.00043

Article  PubMed  PubMed Central  Google Scholar 

Ho L, Ono K, Tsuji M, Mazzola P, Singh R, Pasinetti GM (2018) Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms. Expert Rev Neurother 18:83–90. https://doi.org/10.1080/14737175.2018.1400909

Article  PubMed  CAS  Google Scholar 

Hooper LV, Gordon JI (2001) Commensal host-bacterial relationships in the gut. Science 292:1115–1118. https://doi.org/10.1126/science.1058709

Hoyer S (2002) The brain insulin signal transduction system and sporadic (type II) alzheimer disease: an update. J Neural Transm (Vienna) 109:341–360. https://doi.org/10.1007/s007020200028

Article  PubMed  CAS  Google Scholar 

Hu X, Wang T, Jin F (2016) Alzheimer’s disease and gut microbiota. Sci China Life Sci 59:1006–1023. https://doi.org/10.1007/s11427-016-5083-9

Article  PubMed  CAS  Google Scholar 

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Goldau HB, Alber J, Förster J, Eming CY, Schwaninger SA, Ferrara M, Karsenty N G, Brüning JC (2016) Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165: 882-95. https://doi.org/10.1016/j.cell.2016.03.033

Janani C, Ranjitha Kumari BD (2015) PPAR gamma gene–a review. Diabetes Metab Syndr 9:46–50. https://doi.org/10.1016/j.dsx.2014.09.015

Article  PubMed  CAS  Google Scholar 

Joh EH, Lee IA, Jung IH, Kim DH (2011) Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation–the key step of inflammation. Biochem Pharmacol 82:278–286. https://doi.org/10.1016/j.bcp.2011.05.003

Article  PubMed  CAS  Google Scholar 

Kim HJ, Jung SW, Kim SY, Cho IH, Kim HC, Rhim H, Kim M, Nah SY (2018) Panax ginseng as an adjuvant treatment for Alzheimer’s disease. J Ginseng Res 42:401–411. https://doi.org/10.1016/j.jgr.2017.12.008

Article  PubMed  PubMed Central  Google Scholar 

Kosik KS, Joachim CL, Selkoe DJ (1986) Microtubule-associated protein Tau (tau) is a major antigenic component of paired helical filaments in alzheimer disease. Proc Natl Acad Sci U S A 83:4044–4048. https://doi.org/10.1073/pnas.83.11.4044