Ammal Kaidery N, Ahuja M, Thomas B (2019) Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson’s disease. Mol Cell Neurosci 101:103413. https://doi.org/10.1016/j.mcn.2019.103413
Article CAS PubMed PubMed Central Google Scholar
Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis 1863:1066–1077. https://doi.org/10.1016/j.bbadis.2016.11.010
Article CAS PubMed Google Scholar
Brandes MS, Gray NE (2020) NRF2 as a therapeutic target in neurodegenerative diseases. ASN Neuro 12:1759091419899782. https://doi.org/10.1177/1759091419899782
Article CAS PubMed PubMed Central Google Scholar
Brillo V, Chieregato L, Leanza L, Muccioli S, Costa R (2021) Mitochondrial dynamics, ROS, and cell signaling: a blended overview. Life (Basel) 11. https://doi.org/10.3390/life11040332
Casanova A, Wevers A, Navarro-Ledesma S, Pruimboom L (2023) Mitochondria: It is all about energy. Front Physiol 14:1114231. https://doi.org/10.3389/fphys.2023.1114231
Article PubMed PubMed Central Google Scholar
Cenini G, Voos W (2019) Mitochondria as potential targets in Alzheimer disease therapy: an update. Front Pharmacol 10:902. https://doi.org/10.3389/fphar.2019.00902
Article CAS PubMed PubMed Central Google Scholar
Fao L, Mota SI, Rego AC (2019) Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases. Ageing Res Rev 54:100942. https://doi.org/10.1016/j.arr.2019.100942
Article CAS PubMed Google Scholar
Gokce EC, Kahveci R, Atanur OM, Gurer B, Aksoy N, Gokce A, Sargon MF, Cemil B, Erdogan B, Kahveci O (2015) Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats. Injury 46:2146–2155. https://doi.org/10.1016/j.injury.2015.08.017
Guo MF, Zhang HY, Zhang PJ, Liu XQ, Song LJ, Wei WY, Wang YY, Mu BT, Chai Z, Yu JZ, Ma CG (2020) Fasudil reduces beta-amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice viainhibition of the Nogo-A/NgR/RhoA signaling axis. J Integr Neurosci 19:651–662. https://doi.org/10.31083/j.jin.2020.04.243
Hannan MA, Dash R, Sohag AAM, Haque MN, Moon IS (2020) Neuroprotection against oxidative stress: phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system. Front Mol Neurosci 13:116. https://doi.org/10.3389/fnmol.2020.00116
Article CAS PubMed PubMed Central Google Scholar
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G (2017) Polysaccharides from ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer’s disease. Stem Cell Reports 8:84–94. https://doi.org/10.1016/j.stemcr.2016.12.007
Article CAS PubMed PubMed Central Google Scholar
Jezek J, Cooper KF, Strich R (2018) Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression. Antioxidants (Basel) 7:13. https://doi.org/10.3390/antiox7010013
Article CAS PubMed Google Scholar
Jiang J, Pan H, Shen F, Tan Y, Chen S (2023) Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-kappaB signaling pathways. Neural Regen Res 18:2767–2772. https://doi.org/10.4103/1673-5374.373715
Article CAS PubMed PubMed Central Google Scholar
Kang TC (2020) Nuclear factor-erythroid 2-related factor 2 (Nrf2) and mitochondrial dynamics/mitophagy in neurological diseases. Antioxidants (Basel) 9:617. https://doi.org/10.3390/antiox9070617
Article CAS PubMed Google Scholar
Koelsch G (2017) BACE1 function and inhibition: implications of intervention in the amyloid pathway of Alzheimer’s disease pathology. Molecules 22:1723. https://doi.org/10.3390/molecules22101723
Article CAS PubMed PubMed Central Google Scholar
Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC (2008) Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res 1190:215–224. https://doi.org/10.1016/j.brainres.2007.10.103
Article CAS PubMed Google Scholar
Liu X, Song L, Yu J, Huang F, Li Y, Ma C (2022) Mdivi-1: a promising drug and its underlying mechanisms in the treatment of neurodegenerative diseases. Histol Histopathol 37:505–512. https://doi.org/10.14670/HH-18-443
Article CAS PubMed Google Scholar
Nabi SU, Khan A, Siddiqui EM, Rehman MU, Alshahrani S, Arafah A, Mehan S, Alsaffar RM, Alexiou A, Shen B (2022) Mechanisms of mitochondrial malfunction in Alzheimer’s disease: new therapeutic hope. Oxid Med Cell Longev 2022:4759963. https://doi.org/10.1155/2022/4759963
Article CAS PubMed PubMed Central Google Scholar
Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O’Rourke R, O’Rourke S, Ingraham C et al (2021) Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study. Front Aging Neurosci 13:713726. https://doi.org/10.3389/fnagi.2021.713726
Article CAS PubMed PubMed Central Google Scholar
Rojo AI, Pajares M, Rada P, Nunez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M et al (2017) NRF2 deficiency replicates transcriptomic changes in Alzheimer’s patients and worsens APP and TAU pathology. Redox Biol 13:444–451. https://doi.org/10.1016/j.redox.2017.07.006
Article CAS PubMed PubMed Central Google Scholar
Seweryn E, Ziala A, Gamian A (2021) Health-promoting of polysaccharides extracted from Ganoderma lucidum. Nutrients 13:2725. https://doi.org/10.3390/nu13082725
Article CAS PubMed PubMed Central Google Scholar
Shi M, Zhang Z, Yang Y (2013) Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP). Carbohydr Polym 95:200–206. https://doi.org/10.1016/j.carbpol.2013.02.081
Article CAS PubMed Google Scholar
Sun XZ, Liao Y, Li W, Guo LM (2017) Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Neural Regen Res 12:953–958. https://doi.org/10.4103/1673-5374.208590
Article CAS PubMed PubMed Central Google Scholar
Sun Y, Hou S, Song S, Zhang B, Ai C, Chen X, Liu N (2018) Impact of acidic, water and alkaline extraction on structural features, antioxidant activities of Laminaria japonica polysaccharides. Int J Biol Macromol 112:985–995. https://doi.org/10.1016/j.ijbiomac.2018.02.066
Article CAS PubMed Google Scholar
Tzioras M, McGeachan RI, Durrant CS, Spires-Jones TL (2023) Synaptic degeneration in Alzheimer disease. Nat Rev Neurol 19:19–38. https://doi.org/10.1038/s41582-022-00749-z
Ullah R, Ali G, Subhan F, Khan A, Ahsan Halim S, Naveed M, Kalsoom S, Al-Harrasi A (2021) Attenuation of spatial memory in 5xFAD mice by targeting cholinesterases, oxidative stress and inflammatory signaling using 2-(hydroxyl-(2-nitrophenyl)methyl)cyclopentanone. Int Immunopharmacol 100:108083. https://doi.org/10.1016/j.intimp.2021.108083
Article CAS PubMed Google Scholar
Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M (2020) Nrf2 suppresses oxidative stress and inflammation in app knock-In Alzheimer’s disease model mice. Mol Cell Biol 40:e00467-e519. https://doi.org/10.1128/MCB.00467-19
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