Alster TS, Tanzi EL (2003) Hypertrophic scars and keloids: etiology and management. Am J Clin Dermatol 4:235–243

PubMed  Google Scholar 

DEITCH EA, WHEELAHAN TM, ROSE MP, Clothier J, Cotter J (1983) Hypertrophic burn scars: analysis of variables. J Trauma Acute Care Surg 23(10):895–898

CAS  Google Scholar 

English RS, Shenefelt PD (1999) Keloids and hypertrophic scars. Dermatol Surg 25(8):631–638

CAS  PubMed  Google Scholar 

Pollack SV, Goslen JB (1982) The Surgical Treatment of keloids. J Dermatol Surg Oncol 8(12):1045–1049

CAS  PubMed  Google Scholar 

Mathangi-Ramarkrishnan K, Pothan-Thomas K, Cheyyur R (1974) Study of 1,000 patients with keloidal scars in South India. Plast Reconst Surg 53:276–280

Google Scholar 

Urioste SS, Arndt KA, Dover JS (eds) (1999) Keloids and hypertrophic scars: review and treatment strategies. Seminars in cutaneous medicine and surgery

Abrams BJ, Benedetto AV, Humeniuk HM (1993) Exuberant keloidal formation. J Osteopath Med 93(8):863

CAS  Google Scholar 

Rockwell WB, Cohen IK, Ehrlich HP (1989) Keloids and hypertrophic scars: a comprehensive review. Plast Reconstr Surg 84(5):827–837

CAS  PubMed  Google Scholar 

Rudolph R (1987) Wide spread scars, hypertrophic scars, and keloids. Clin Plast Surg 14(2):253–260

CAS  PubMed  Google Scholar 

Nakaoka H, Miyauchi S, Miki Y (1995) Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. Acta dermato-venereologica 75(2):102–104

CAS  PubMed  Google Scholar 

Jafarzadeh A, PourMohammad A, Goodarzi A (2024) A systematic review of the efficacy, safety and satisfaction of regenerative medicine treatments, including platelet-rich plasma, stromal vascular fraction and stem cell-conditioned medium for hypertrophic scars and keloids. Int Wound J 21(4):e14557

PubMed  Google Scholar 

Lee HJ, Jang YJ (2018) Recent understandings of Biology, Prophylaxis and Treatment strategies for hypertrophic scars and keloids. Int J Mol Sci 19(3)

Deng C-C, Hu Y-F, Zhu D-H, Cheng Q, Gu J-J, Feng Q-L et al (2021) Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun 12(1):3709

CAS  PubMed  PubMed Central  Google Scholar 

Douglas H, Lynch J, Harms K-A, Krop T, Kunath L, van Vreeswijk C et al (2019) Carbon dioxide laser treatment in burn-related scarring: a prospective randomised controlled trial. J Plast Reconstr Aesthetic Surg 72(6):863–870

Google Scholar 

Roohaninasab M, Khodadad F, Sadeghzadeh-Bazargan A, Atefi N, Zare S, Jafarzadeh A et al (2023) Efficacy of fractional CO(2) laser in combination with stromal vascular fraction (SVF) compared with fractional CO(2) laser alone in the treatment of burn scars: a randomized controlled clinical trial. Stem Cell Res Ther 14(1):269

CAS  PubMed  PubMed Central  Google Scholar 

Kivi MK, Jafarzadeh A, Hosseini-Baharanchi FS, Salehi S, Goodarzi A (2024) The efficacy, satisfaction, and safety of carbon dioxide (CO2) fractional laser in combination with pulsed dye laser (PDL) versus each one alone in the treatment of hypertrophic burn scars: a single-blinded randomized controlled trial. Lasers Med Sci 39(1):69

PubMed  Google Scholar 

Ahmadi M, Khalili H (2016) Potential benefits of pentoxifylline on wound healing. Expert Rev Clin Pharmacol 9(1):129–142

CAS  PubMed  Google Scholar 

Hassan I, Dorjay K, Anwar P (2014) Pentoxifylline and its applications in dermatology. Indian Dermatology Online J 5(4):510–516

Google Scholar 

Kim EY, Hussain A, Khachemoune A (2023) Evidence-based management of keloids and hypertrophic scars in dermatology. Arch Dermatol Res 315(6):1487–1495

PubMed  Google Scholar 

Rawlins JM, Lam WL, Karoo RO, Naylor IL, Sharpe DT (2006) Pentoxifylline inhibits mature burn scar fibroblasts in culture. Burns 32(1):42–45

CAS  PubMed  Google Scholar 

Peng W, Zhang X, Kong X, Shi K (2021) The efficacy and safety of fractional CO2 laser therapy in the treatment of burn scars: a meta-analysis. Burns 47(7):1469–1477

PubMed  Google Scholar 

Azzam O, Bassiouny D, El-Hawary M, El Maadawi Z, Sobhi R, El-Mesidy M (2016) Treatment of hypertrophic scars and keloids by fractional carbon dioxide laser: a clinical, histological, and immunohistochemical study. Lasers Med Sci 31:9–18

CAS  PubMed  Google Scholar 

Poetschke J, Dornseifer U, Clementoni MT, Reinholz M, Schwaiger H, Steckmeier S et al (2017) Ultrapulsed fractional ablative carbon dioxide laser treatment of hypertrophic burn scars: evaluation of an in-patient controlled, standardized treatment approach. Lasers Med Sci 32:1031–1040

PubMed  Google Scholar 

Choi KJ, Williams EA, Pham CH, Collier ZJ, Dang J, Yenikomshian HA et al (2021) Fractional CO2 laser treatment for burn scar improvement: a systematic review and meta-analysis. Burns 47(2):259–269

PubMed  Google Scholar 

Yang F, Chen E, Yang Y, Han F, Han S, Wu G et al (2019) The Akt/FoxO/p27Kip1 axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars. J Cell Mol Med 23(9):6164–6172

CAS  PubMed  PubMed Central  Google Scholar 

Isaac C, Mathor MB, Bariani G, Paggiaro AO, Herson MR, Goldenstein-Schainberg C et al (2009) Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin. Burns 35(5):701–706

PubMed  Google Scholar 

Isaac C, Carvalho VF, Paggiaro AO, de Maio M, Ferreira MC (2010) Intralesional pentoxifylline as an adjuvant treatment for perioral post-burn hypertrophic scars. Burns 36(6):831–835

PubMed  Google Scholar 

Serag-Eldin YMA, Mahmoud WH, Gamea MM, Hegab DS (2021) Intralesional pentoxifylline, triamcinolone acetonide, and their combination for treatment of keloid scars. J Cosmet Dermatol 20(10):3330–3340

PubMed  Google Scholar 

Roohaninasab M, Najar Nobari N, Ghassemi M, Behrangi E, Jafarzadeh A, Sadeghzadeh-Bazargan A, Goodarzi A (2024) A systematic review of procedural treatments for burn scars in children: evaluating efficacy, safety, standard protocols, average sessions and tolerability based on clinical studies. Int Wound J 21(10):e70091. https://doi.org/10.1111/iwj.70091PMID: 39379072; PMCID: PMC11461021

PubMed  PubMed Central  Google Scholar