Lushnikova E, Klinnikova M, Molodykh O, Nepomnyashchikh L. Morphological manifestations of heart remodeling in anthracycline-induced dilated cardiomyopathy. Bull Exp Biol Med. 2004;138:607–12. https://doi.org/10.1007/s10517-005-0138-0
Article CAS PubMed Google Scholar
Octavia Y, Tocchetti CG, Gabrielson KL, et al. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 2012;52(6):1213–25. https://doi.org/10.1016/j.yjmcc.2012.03.006
Article CAS PubMed Google Scholar
Dulf PL, Mocan M, Coadă CA, et al. Doxorubicin-induced acute cardiotoxicity is associated with increased oxidative stress, autophagy, and inflammation in a murine model. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(6):1105–15. https://doi.org/10.1007/s00210-023-02382-z
Article CAS PubMed PubMed Central Google Scholar
Mitry MA, Edwards JG. Doxorubicin induced heart failure: Phenotype and molecular mechanisms. Int J Cardiol Heart Vasc. 2016;10:17–24. https://doi.org/10.1016/j.ijcha.2015.11.004
Hoeger CW, Turissini C, Asnani A. Doxorubicin cardiotoxicity: pathophysiology updates. Curr Treat Options Cardio Med. 2020;22:1–17. https://doi.org/10.1007/s11936-020-00842-w
Zhou S, Palmeira CM, Wallace KB. Doxorubicin-induced persistent oxidative stress to cardiac myocytes. Toxicol Lett. 2001;121(3):151–7. https://doi.org/10.1016/s0378-4274(01)00329-0
Article CAS PubMed Google Scholar
Wu R, Wang H-L, Yu H-L, et al. Doxorubicin toxicity changes myocardial energy metabolism in rats. Chem Biol Interact. 2016;244:149–58. https://doi.org/10.1016/j.cbi.2015.12.010
Article CAS PubMed Google Scholar
Carvalho RA, Sousa RP, Cadete VJ, et al. Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy. Toxicology. 2010;270(2–3):92–8. https://doi.org/10.1016/j.tox.2010.01.019
Article CAS PubMed Google Scholar
Zahler D, Arnold JH, Bar-On T, et al. Valvular heart disease following anthracycline therapy—is it time to look beyond ejection fraction? Life. 2022;12(8):1275. https://doi.org/10.3390/life12081275
Article CAS PubMed PubMed Central Google Scholar
Kinoshita T, Yuzawa H, Natori K, et al. Early electrocardiographic indices for predicting chronic doxorubicin-induced cardiotoxicity. J Cardiol. 2021;77(4):388–94. https://doi.org/10.1016/j.jjcc.2020.10.007
Mobaraki M, Faraji A, Zare M, et al. Molecular mechanisms of cardiotoxicity: a review on major side-effect of doxorubicin. Indian J Pharm Sci. 2017;79:335–44. https://doi.org/10.4172/pharmaceutical-sciences.1000235
Ghasemi K, Vaseghi G, Mansourian M. Pharmacological interventions for preventing anthracycline-induced clinical and subclinical cardiotoxicity: a network meta-analysis of metastatic breast cancer. J Oncol Pharm Pract. 2021;27(2):414–27. https://doi.org/10.1177/1078155220965674
Article CAS PubMed Google Scholar
Liao Y, Meng Q. Protection against cancer therapy-induced cardiovascular injury by planed-derived polyphenols and nanomaterials. Environ Res. 2023;238(Pt 2): 116896. https://doi.org/10.1016/j.envres.2023.116896
Article CAS PubMed Google Scholar
Li K, Chen W, Ma L, Yan L, Wang B. Approaches for reducing chemo/radiation-induced cardiotoxicity by nanoparticles. Environ Res. 2024;244:117264. https://doi.org/10.1016/j.envres.2023.117264
Article CAS PubMed Google Scholar
Azevedo PS, Polegato BF, Minicucci MF, Paiva SA, Zornoff LA. Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment. Arq Bras Cardiol. 2016;106(1):62–9. https://doi.org/10.5935/abc.20160005
Article CAS PubMed PubMed Central Google Scholar
Anzai T. Inflammatory mechanisms of cardiovascular remodeling. Circ J. 2018;82(3):629–35. https://doi.org/10.1253/circj.CJ-18-0063
Article CAS PubMed Google Scholar
Kehat I, Molkentin JD. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation. 2010;122(25):2727–35. https://doi.org/10.1161/circulationaha.110.942268
Nishida M, Mi X, Ishii Y, Kato Y, Nishimura A. Cardiac remodeling: novel pathophysiological mechanisms and therapeutic strategies. J Biochem. 2024;176(4):255–62. https://doi.org/10.1093/jb/mvae031
Article CAS PubMed Google Scholar
González A, Schelbert EB, Díez J, Butler J. Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. J Am Coll Cardiol. 2018;71(15):1696–706. https://doi.org/10.1016/j.jacc.2018.02.021
Díez J, González A, Kovacic JC. Myocardial interstitial fibrosis in nonischemic heart disease, part 3/4: JACC focus seminar. J Am Coll Cardiol. 2020;75(17):2204–18. https://doi.org/10.1016/j.jacc.2020.03.019
Article CAS PubMed PubMed Central Google Scholar
García-Redondo AB, Aguado A, Briones AM, Salaices M. NADPH oxidases and vascular remodeling in cardiovascular diseases. Pharmacol Res. 2016;114:110–20. https://doi.org/10.1016/j.phrs.2016.10.015
Article CAS PubMed Google Scholar
Chandrasekhar J, Dangas G, Mehran R. Valvular heart disease in women, differential remodeling, and response to new therapies. Curr Treat Options Cardiovasc Med. 2017;19(9):74. https://doi.org/10.1007/s11936-017-0573-z
Suthahar N, Meijers WC, Silljé HH, de Boer RA. From inflammation to fibrosis—molecular and cellular mechanisms of myocardial tissue remodelling and perspectives on differential treatment opportunities. Curr Heart Fail Rep. 2017;14(4):235–50. https://doi.org/10.1007/s11897-017-0343-y
Article CAS PubMed PubMed Central Google Scholar
Fu X, Tang J, Wen P, Huang Z, Najafi M. Redox interactions-induced cardiac toxicity in cancer therapy. Arch Biochem Biophys. 2021;708:108952. https://doi.org/10.1016/j.abb.2021.108952
Article CAS PubMed Google Scholar
Osataphan N, Phrommintikul A, Chattipakorn SC, Chattipakorn N. Effects of doxorubicin-induced cardiotoxicity on cardiac mitochondrial dynamics and mitochondrial function: Insights for future interventions. J Cell Mol Med. 2020;24(12):6534–57. https://doi.org/10.1111/jcmm.15305
Article PubMed PubMed Central Google Scholar
Kitakata H, Endo J, Ikura H, et al. Therapeutic targets for DOX-induced cardiomyopathy: role of apoptosis vs. ferroptosis. Int J Mol Sci. 2022;23(3):1414. https://doi.org/10.3390/ijms23031414
Christidi E, Brunham LR. Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2021;12(4):339. https://doi.org/10.1038/s41419-021-03614-x
Article CAS PubMed PubMed Central Google Scholar
Pecoraro M, Del Pizzo M, Marzocco S, et al. Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity. Toxicol Appl Pharmacol. 2016;293:44–52. https://doi.org/10.1016/j.taap.2016.01.006
Article CAS PubMed Google Scholar
Shi S, Chen Y, Luo Z, Nie G, Dai Y. Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy. Cell Commun Signal. 2023;21(1):61. https://doi.org/10.1186/s12964-023-01077-5
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