Effect of Verapamil on Blood Glucose in Type 1 and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Kaur J, Seaquist ER. Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies. Nat Rev Endocrinol. 2023;19:177–86. https://doi.org/10.1038/s41574-022-00762-8

Article  PubMed  Google Scholar 

Fineberg SE, Kawabata TT, Finco-Kent D, Fountaine RJ, Finch GL, Krasner AS. Immunological responses to exogenous insulin. Endocr Rev. 2007;28:625–52. https://doi.org/10.1210/er.2007-0002

Article  CAS  PubMed  Google Scholar 

Meneses MJ, Silva BM, Sousa M, Sa R, Oliveira PF, Alves MG. Antidiabetic drugs: mechanisms of action and potential outcomes on cellular metabolism. Curr Pharm Des. 2015;21:3606–20. https://doi.org/10.2174/1381612821666150710145753

Article  CAS  PubMed  Google Scholar 

Thomas CC, Chopra K, Davis AM. Management of outpatients with diabetes at high risk of hypoglycemia. JAMA. 2024;331:1145–6. https://doi.org/10.1001/jama.2024.1137

Article  PubMed  Google Scholar 

Thomas MK, Nikooienejad A, Bray R, et al. Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab. 2021;106:388–96. https://doi.org/10.1210/clinem/dgaa863

Article  PubMed  Google Scholar 

Zhao K, Shi Y, Yu J, et al. In vivo Ca(V)3 channel inhibition promotes maturation of glucose-dependent Ca(2+) signaling in human iPSC-islets. Biomedicines. 2023;11:807. https://doi.org/10.3390/biomedicines11030807

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobson DA, Shyng SL. Ion channels of the islets in type 2 diabetes. J Mol Biol. 2020;432:1326–46. https://doi.org/10.1016/j.jmb.2019.08.014

Article  CAS  PubMed  Google Scholar 

Chen C, Chmelova H, Cohrs CM, et al. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes. 2016;65:2676–85. https://doi.org/10.2337/db15-1718

Article  CAS  PubMed  Google Scholar 

Ovalle F, Grimes T, Xu G, et al. Verapamil and beta cell function in adults with recent-onset type 1 diabetes. Nat Med. 2018;24:1108–12. https://doi.org/10.1038/s41591-018-0089-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vogel J, Yin J, Su L, et al. A phenotypic screen identifies calcium overload as a key mechanism of β-cell glucolipotoxicity. Diabetes. 2020;69:1032–41. https://doi.org/10.2337/db19-0813

Article  CAS  PubMed  Google Scholar 

Xu G, Chen J, Lu B, Sethupathy P, Qian WJ, Shalev A. Verapamil prevents decline of IGF-I in subjects with type 1 diabetes and promotes β-cell IGF-I signaling. Diabetes. 2023;72:1460–9. https://doi.org/10.2337/db23-0256

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Addio F, Maestroni A, Assi E, et al. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nat Commun. 2022;13:684. https://doi.org/10.1038/s41467-022-28360-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Wu Y, Song Y, et al. Activation of NF-κB-inducing kinase in islet β cells causes β cell failure and diabetes. Mol Ther. 2020;28:2430–41. https://doi.org/10.1016/j.ymthe.2020.07.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meyerovich K, Ortis F, Cardozo AK. The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes. J Mol Endocrinol. 2018;61:F1-f6. https://doi.org/10.1530/jme-16-0183

Article  CAS  PubMed  Google Scholar 

Wondafrash DZ, Nire’a AT, Tafere GG, Desta DM, Berhe DA, Zewdie KA. Thioredoxin-interacting protein as a novel potential therapeutic target in diabetes mellitus and its underlying complications. Diabetes Metab Syndr Obes. 2020;13:43–51. https://doi.org/10.2147/dmso.S232221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Aisker G, Dong H, Halemahebai G, Zhang Y, Tian L. Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. Phytomedicine. 2021;93:153741. https://doi.org/10.1016/j.phymed.2021.153741

Article  CAS  PubMed  Google Scholar 

Xu G, Chen J, Jing G, Shalev A. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes. 2012;61:848–56. https://doi.org/10.2337/db11-0955

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eissa LD, Ghobashy WA, El-Azab MF. Inhibition of thioredoxin-interacting protein and inflammasome assembly using verapamil mitigates diabetic retinopathy and pancreatic injury. Eur J Pharmacol. 2021;901:174061. https://doi.org/10.1016/j.ejphar.2021.174061

Article  CAS  PubMed  Google Scholar 

Borowiec AM, Właszczuk A, Olakowska E, Lewin-Kowalik J. TXNIP inhibition in the treatment of diabetes. Verapamil as a novel therapeutic modality in diabetic patients. Med Pharm Rep. 2022;95:243–50. https://doi.org/10.15386/mpr-2187

Article  PubMed  PubMed Central  Google Scholar 

Wu N, Zheng B, Shaywitz A, et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013;49:1167–75. https://doi.org/10.1016/j.molcel.2013.01.035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klec C, Ziomek G, Pichler M, Malli R, Graier WF. Calcium signaling in ß-cell physiology and pathology: a revisit. Int J Mol Sci. 2019;20:6110. https://doi.org/10.3390/ijms20246110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel S, Santani D. Role of NF-kappa B in the pathogenesis of diabetes and its associated complications. Pharmacol Rep. 2009;61:595–603. https://doi.org/10.1016/s1734-1140(09)70111-2

Article  CAS  PubMed  Google Scholar 

Klimczak S, Śliwińska A. Epigenetic regulation of inflammation in insulin resistance. Semin Cell Dev Biol. 2024;154:185–92. https://doi.org/10.1016/j.semcdb.2022.09.004

Article  CAS  PubMed  Google Scholar 

Khodneva Y, Shalev A, Frank SJ, Carson AP, Safford MM. Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study. Diabetes Res Clin Pract. 2016;115:115–21. https://doi.org/10.1016/j.diabres.2016.01.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen YS, Weng SJ, Chang SH, et al. Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models. PLoS ONE. 2021;16:e0255405. https://doi.org/10.1371/journal.pone.0255405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han SY, Choi YH. Pharmacokinetic interaction between metformin and verapamil in rats: inhibition of the OCT2-mediated renal excretion of metformin by verapamil. Pharmaceutics. 2020;12:468. https://doi.org/10.3390/pharmaceutics12050468

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Q, Zhao Q, Chen Y, et al. Galectin-3 impairs calcium transients and β-cell function. Nat Commun. 2024;15:3682. https://doi.org/10.1038/s41467-024-47959-1

Article  CAS 

Comments (0)

No login
gif