Prospective clinical study of sentinel node detection in bladder cancer using a hybrid tracer – Towards replacement of pelvic lymph node dissection in cases with sentinel node visualization on SPECT/CT?

Witjes JA, Bruins HM, Carrión A, Cathomas R, Compérat EM, Efstathiou JA, et al. Muscle-invasive and metastatic bladder cancer. EAU Guidelines on muscle-invasive and metastatic bladder cancer. 2024.

Perera M, McGrath S, Sengupta S, Crozier J, Bolton D, Lawrentschuk N. Pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer. Nat Rev Urol. 2018;15:686–92.

PubMed  Google Scholar 

Bruins HM, Veskimae E, Hernandez V, Imamura M, Neuberger MM, Dahm P, et al. The impact of the extent of lymphadenectomy on oncologic outcomes in patients undergoing radical cystectomy for bladder cancer: a systematic review. Eur Urol. 2014;66:1065–77.

PubMed  Google Scholar 

Lerner SP, Tangen C, Svatek RS, Daneshmand S, Pohar KS, Skinner E, et al. Standard or extended lymphadenectomy for muscle-invasive bladder cancer. N Engl J Med. 2024;391:1206–16.

PubMed  PubMed Central  Google Scholar 

Horenblas S, Jansen L, Meinhardt W, Hoefnagel CA, de Jong D, Nieweg OE. Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure. J Urol. 2000;163:100–4.

PubMed  Google Scholar 

Wawroschek F, Vogt H, Weckermann D, Wagner T, Harzmann R. The sentinel lymph node concept in prostate cancer - first results of gamma probe-guided sentinel lymph node identification. Eur Urol. 1999;36:595–600.

PubMed  Google Scholar 

van der Poel HG, Buckle T, Brouwer OR, Valdés Olmos RA, van Leeuwen FWB. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol. 2011;60:826–33.

PubMed  Google Scholar 

Dell’Oglio P, de Vries HM, Mazzone E, KleinJan GH, Donswijk ML, van der Poel HG, et al. Hybrid indocyanine Green-99mTc-nanocolloid for single-photon emission computed tomography and combined radio- and fluorescence-guided sentinel node biopsy in penile cancer: results of 740 inguinal basins assessed at a single institution. Eur Urol. 2020;78:865–72.

PubMed  Google Scholar 

Nieweg OE, Tanis PJ, Kroon BB. The definition of a sentinel node. Ann Surg Oncol. 2001;8:538–41.

PubMed  Google Scholar 

Sherif A, De La Torre M, Malmström PU, Thörn M. Lymphatic mapping and detection of sentinel nodes in patients with bladder cancer. J Urol. 2001;166:812–5.

PubMed  Google Scholar 

Liedberg F, Chebil G, Davidsson T, Gudjonsson S, Månsson W. Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol. 2006;175:84–8 discussion 88-89).

PubMed  Google Scholar 

Marits P, Karlsson M, Sherif A, Garske U, Thörn M, Winqvist O. Detection of immune responses against urinary bladder cancer in sentinel lymph nodes. Eur Urol. 2006;49:59–70.

PubMed  Google Scholar 

Patel MN, Hemal AK. Molecular targeted fluorescence-guided intraoperative imaging of bladder cancer nodal drainage using indocyanine green during radical and partial cystectomy. Curr Urol Rep. 2016;17:74.

PubMed  Google Scholar 

Schaafsma BE, Verbeek FPR, Elzevier HW, Tummers QRJG, van der Vorst JR, Frangioni JV, et al. Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging. J Surg Oncol. 2014;110:845–50.

PubMed  PubMed Central  Google Scholar 

Polom W, Markuszewski M, Cytawa W, Czapiewski P, Lass P, Matuszewski M. Fluorescent versus radioguided lymph node mapping in bladder cancer. Clin Genitourin Cancer. 2017;15:e405–9.

PubMed  Google Scholar 

Navarro AS, Angeles MA, Migliorelli F, Illac C, Martínez-Gómez C, Leray H, et al. Comparison of SPECT-CT with intraoperative mapping in cervical and uterine malignancies. Int J Gynecol Cancer. 2021;31(5):679–85.

PubMed  Google Scholar 

KleinJan GH, van Werkhoven E, van den Berg NS, Karakullukcu MB, Zijlmans HJM a. A, van der Hage JA, et al. The best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes. Eur J Nucl Med Mol Imaging. 2018;45:1915–25.

Brouwer OR, van den Berg NS, Mathéron HM, van der Poel HG, van Rhijn BW, Bex A, et al. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. Eur Urol. 2014;65:600–9.

PubMed  Google Scholar 

Rietbergen DDD, van Gennep EJ, KleinJan GH, Donswijk M, Valdés Olmos RA, van Rhijn BW, et al. Evaluation of the hybrid tracer indocyanine green- 99m Tc-Nanocolloid for sentinel node biopsy in bladder cancer-a prospective pilot study. Clin Nucl Med. 2022;47:774–80.

PubMed  PubMed Central  Google Scholar 

Dell’Oglio P, Meershoek P, Maurer T, Wit EMK, van Leeuwen PJ, van der Poel HG, et al. A DROP-IN gamma probe for robot-assisted radioguided surgery of lymph nodes during radical prostatectomy. Eur Urol. 2021;79:124–32.

PubMed  Google Scholar 

Püllen L, Costa PF, Darr C, Hess J, Kesch C, Rehme C, et al. Near-infrared fluorescence lymph node template region dissection plus backup lymphadenectomy in open radical cystectomy for bladder cancer using an innovative handheld device: A single center experience. J Surg Oncol. 2024;129:1325–31.

PubMed  Google Scholar 

Sherif A, Garske U, de la Torre M, Thörn M. Hybrid SPECT-CT: an additional technique for sentinel node detection of patients with invasive bladder cancer. Eur Urol. 2006;50:83–91.

PubMed  Google Scholar 

Mazzone E, Dell’Oglio P, Grivas N, Wit E, Donswijk M, Briganti A, et al. Diagnostic value, oncologic outcomes, and safety profile of image-guided surgery technologies during robot-assisted lymph node dissection with sentinel node biopsy for prostate cancer. J Nucl Med Off Publ Soc Nucl Med. 2021;62:1363–71.

Google Scholar 

Małkiewicz B, Jędrzejuk D, Gurwin A, Wilk K, Knecht-Gurwin K, Kiełb P, et al. Diagnostic value of the sentinel lymph node technique in patients with muscle-invasive bladder cancer. J Clin Med. 2023;12:3092.

PubMed  PubMed Central  Google Scholar 

de Barros HA, Duin JJ, Mulder D, van der Noort V, Noordzij MA, Wit EMK, et al. Sentinel node procedure to select clinically localized prostate cancer patients with occult nodal metastases for whole pelvis radiotherapy. Eur Urol Open Sci. 2023;49:80–9.

PubMed  PubMed Central  Google Scholar 

Patten DK, Zacharioudakis KE, Chauhan H, Cleator SJ, Hadjiminas DJ. Sentinel lymph node biopsy after neo-adjuvant chemotherapy in patients with breast cancer: Are the current false negative rates acceptable? Breast Edinb Scotl. 2015;24:318–20.

Google Scholar 

Rosenblatt R, Johansson M, Alamdari F, Sidiki A, Holmström B, Hansson J, et al. Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report. World J Urol. 2017;35:921–7.

PubMed  Google Scholar 

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