Malhi GS, Mann JJ (2018) Depression. Lancet (London, England) 392:2299–2312. https://doi.org/10.1016/S0140-6736(18)31948-2

Article  PubMed  Google Scholar 

Lee LO, Grimm KJ, Spiro A 3rd, Kubzansky LD (2022) Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40-Year Study of Men. J Am Heart Assoc 11:e022006. https://doi.org/10.1161/JAHA.121.022006

Article  PubMed  PubMed Central  Google Scholar 

Chida Y, Steptoe A (2008) Positive psychological well-being and mortality: a quantitative review of prospective observational studies. Psychosom Med 70:741–756. https://doi.org/10.1097/PSY.0b013e31818105ba

Article  PubMed  Google Scholar 

Lewis LD (2021) The interconnected causes and consequences of sleep in the brain. Science (New York, NY) 374:564–568. https://doi.org/10.1126/science.abi8375

Article  CAS  Google Scholar 

Patel SR (2019) Obstructive sleep apnea. Ann Internal Med 171:ITC81–ITC96

Article  Google Scholar 

Kim J-Y, Ko I, Kim D-K (2019) Association of Obstructive Sleep Apnea With the Risk of Affective Disorders. JAMA Otolaryngol Head Neck Surg 145:1020–1026

Article  PubMed  PubMed Central  Google Scholar 

Liao J, Gao X, Shi Y et al (2023) Evaluation of obstructive sleep apnea: an analysis based on aberrant genes. Sleep Breathing = Schlaf Atmung 27:1419–1431

Article  PubMed  Google Scholar 

Garbarino S, Bardwell WA, Guglielmi O et al (2020) Association of anxiety and depression in obstructive sleep apnea patients: a systematic review and meta-analysis. Behav Sleep Med 18:35–57. https://doi.org/10.1080/15402002.2018.1545649

Article  PubMed  Google Scholar 

Kendzerska T, Gershon AS, Hawker GA et al (2017) Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study. The Eur Respiratory J. https://doi.org/10.1183/13993003.01361-2016

Article  Google Scholar 

Giles TL, Lasserson TJ, Smith BJ, et al (2006) Continuous positive airways pressure for obstructive sleep apnoea in adults. The Cochrane database of systematic reviews CD001106. https://doi.org/10.1002/14651858.CD001106.pub2

So S-J, Lee H-J, Kang S-G et al (2015) A comparison of personality characteristics and psychiatric symptomatology between upper airway resistance syndrome and obstructive sleep apnea syndrome. Psychiatry Investig 12:183–189. https://doi.org/10.4306/pi.2015.12.2.183

Article  PubMed  PubMed Central  Google Scholar 

Haba-Rubio J (2005) Psychiatric aspects of organic sleep disorders. Dialogues Clin Neurosci 7:335–346

Article  PubMed  PubMed Central  Google Scholar 

Emdin CA, Khera AV, Kathiresan S (2017) Mendelian Randomization. JAMA 318:1925–1926. https://doi.org/10.1001/jama.2017.17219

Article  PubMed  Google Scholar 

Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: a review. Res Synth Methods 10:486–496. https://doi.org/10.1002/jrsm.1346

Article  PubMed  PubMed Central  Google Scholar 

Gao X, Wei T, Wang H et al (2023) Causal associations between obstructive sleep apnea and COVID-19: a bidirectional Mendelian randomization study. Sleep Med 101:28–35. https://doi.org/10.1016/j.sleep.2022.09.013

Article  PubMed  Google Scholar 

Freuer D, Linseisen J, Meisinger C (2022) Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis: A Bidirectional 2-Sample Mendelian Randomization Study. JAMA Dermatol 158:1262–1268. https://doi.org/10.1001/jamadermatol.2022.3682

Article  PubMed  PubMed Central  Google Scholar 

Strausz S, Ruotsalainen S, Ollila HM et al (2021) Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. The Eur Respiratory J. https://doi.org/10.1183/13993003.03091-2020

Article  Google Scholar 

Zheng H, Shi Y-Z, Liang J-T et al (2023) Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol 14:1010996. https://doi.org/10.3389/fphar.2023.1010996

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife. https://doi.org/10.7554/eLife.34408

Article  PubMed  PubMed Central  Google Scholar 

Sakaue S, Kanai M, Tanigawa Y et al (2021) A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 53:1415–1424. https://doi.org/10.1038/s41588-021-00931-x

Article  CAS  PubMed  Google Scholar 

Howard DM, Adams MJ, Shirali M et al (2021) Author Correction: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. Nat Commun 12:2012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okbay A, Baselmans BML, De Neve J-E et al (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet 48:624–633. https://doi.org/10.1038/ng.3552

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagel M, Jansen PR, Stringer S et al (2018) Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat Genet 50:920–927. https://doi.org/10.1038/s41588-018-0151-7

Article  CAS  PubMed  Google Scholar 

Choi KW, Chen C-Y, Stein MB et al (2019) Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study. JAMA Psychiat 76:399–408. https://doi.org/10.1001/jamapsychiatry.2018.4175

Article  Google Scholar 

Liu M, Fu X, Yu D et al (2024) Mapping the causal associations of cytokines with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization. J Cachexia Sarcopenia Muscle 15:1121–1133. https://doi.org/10.1002/jcsm.13456

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693–698. https://doi.org/10.1038/s41588-018-0099-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Guo Z, Zheng Y et al (2021) No Casual Relationship Between T2DM and the Risk of Infectious Diseases: A Two-Sample Mendelian Randomization Study. Front Genet 12:720874. https://doi.org/10.3389/fgene.2021.720874

Article  PubMed  PubMed Central  Google Scholar 

Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. The Lancet Neurol 9:689–701. https://doi.org/10.1016/S1474-4422(10)70104-6

Article  PubMed  Google Scholar 

Tullberg M, Fletcher E, DeCarli C et al (2004) White matter lesions impair frontal lobe function regardless of their location. Neurology 63:246–253. https://doi.org/10.1212/01.wnl.0000130530.55104.b5

Article  CAS  PubMed  Google Scholar 

Miyamoto O, Auer RN (2000) Hypoxia, hyperoxia, ischemia, and brain necrosis. Neurology 54:362–371. https://doi.org/10.1212/wnl.54.2.362

Article  CAS  PubMed  Google Scholar 

Peng W, Chen R, Jiang Z et al (2014) Correlation between cognitive function and hippocampal atrophy and cerebral white matter lesions in patients with obstructive sleep apnea hypopnea syndrome. Zhonghua Yi Xue Za Zhi 94:724–728

PubMed  Google Scholar 

Feng J, Wu Q, Zhang D, Chen B (2012) Hippocampal impairments are associated with intermittent hypoxia of obstructive sleep apnea. Chin Med J 125:696–701

PubMed