Higher neutrophil-lymphocyte ratio predicts poor response to repetetive transcranial magnetic stimulation(rTMS) in treatment resistant depression

Mazza MG, Lucchi S, Tringali AGM, Rossetti A, Botti ER, Clerici M (2018) Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 84:229–236

Article  PubMed  Google Scholar 

Leonard BE (2018) Inflammation and depression: a causal or coincidental link to the pathophysiology? Acta Neuropsychiatrica 30(1):1–16

Article  PubMed  Google Scholar 

Depression W (2017) Other common mental disorders: global health estimates, vol 24. World Health Organization, Geneva

Google Scholar 

Bennabi D, Charpeaud T, Yrondi A, Genty J-B, Destouches S, Lancrenon S et al (2019) Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental. BMC Psychiatry 19:1–12

Google Scholar 

Rajkumar RP (2023) Immune-inflammatory markers of response to repetitive transcranial magnetic stimulation in depression: a scoping review. Asian J Psychiatry.:103852

Pascual-Leone A, Walsh V, Rothwell J (2000) Transcranial magnetic stimulation in cognitive neuroscience–virtual lesion, chronometry, and functional connectivity. Curr Opin Neurobiol 10(2):232–237

Article  CAS  PubMed  Google Scholar 

Lacroix A, Calvet B, Laplace B, Lannaud M, Plansont B, Guignandon S et al (2021) Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression. Translational Psychiatry 11(1):587

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hebel T, Abdelnaim MA, Deppe M, Kreuzer PM, Mohonko A, Poeppl TB et al (2021) Antidepressant effect of repetitive transcranial magnetic stimulation is not impaired by intake of lithium or antiepileptic drugs. Eur Arch Psychiatry Clin NeuroSci 271(7):1245–1253

Article  CAS  PubMed  PubMed Central  Google Scholar 

White J, Kivimäki M, Jokela M, Batty GD (2017) Association of inflammation with specific symptoms of depression in a general population of older people: the English Longitudinal Study of Ageing. Brain Behav Immun 61:27–30

Article  PubMed  Google Scholar 

Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199–229

Article  CAS  PubMed  Google Scholar 

Liu JJ, Wei YB, Strawbridge R, Bao Y, Chang S, Shi L et al (2020) Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. Mol Psychiatry 25(2):339–350

Article  CAS  PubMed  Google Scholar 

Lang UE, Borgwardt S (2013) Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem 31(6):761–777

Article  CAS  PubMed  Google Scholar 

Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M (2015) Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun 49:206–215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Çakici N, Sutterland AL, Penninx BW, Dalm VA, de Haan L, van Beveren NJ (2020) Altered peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis. Brain Behav Immun 88:547–558

Article  PubMed  Google Scholar 

Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD (2020) Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls. Brain, behavior, and immunity. 87:901–909

Stirton H, Meek BP, Edel AL, Solati Z, Surendran A, Aukema H et al (2021) Oxolipidomics profile in major depressive disorder: comparing remitters and non-remitters to repetitive transcranial magnetic stimulation treatment. PLoS ONE 16(2):e0246592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yilmaz NS, Sen B, Karadag RF, Aslan S, Ekmekci Ertek I, Bozkurt A et al (2022) A kynurenine pathway enzyme aminocarboxymuconate-semialdehyde decarboxylase may be involved in treatment-resistant depression, and baseline inflammation status of patients predicts treatment response: a pilot study. J Neural Transm 129(12):1513–1526

Article  CAS  PubMed  Google Scholar 

Mazza MG, Tringali AGM, Rossetti A, Botti RE, Clerici M (2019) Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders. Gen Hosp Psychiatry 58:7–12

Article  PubMed  Google Scholar 

Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S (2012) Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Archives Med 5(1):1–6

Article  Google Scholar 

Sarikaya S, Aydin İ, Aydin HB, Günenc O, Uysal E, Tuncar A (2023) Can the systemic Immune-inflammation index be used as a marker to Predict Postpartum Depression? Compr Med 15(3):226–233

Google Scholar 

Tang Y, Zeng X, Feng Y, Chen Q, Liu Z, Luo H et al (2021) Association of systemic immune-inflammation index with short-term mortality of congestive heart failure: a retrospective cohort study. Front Cardiovasc Med 8:753133

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen Y, Huang X, Zhang W (2019) Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity—a retrospective study. BMJ open 9(1):e022896

Article  PubMed  PubMed Central  Google Scholar 

Ren A, Li Z, Cheng P, Zhang X, Deng R, Ma Y (2021) Systemic immune-inflammation index is a prognostic predictor in patients with intrahepatic cholangiocarcinoma undergoing liver transplantation. Mediators of Inflammation.;2021

Shao Y, Li W, Wang D, Wu B (2020) Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis. World J Surg Oncol 18:1–16

Article  Google Scholar 

Sunbul EA, Sunbul M, Yanartas O, Cengiz F, Bozbay M, Sari I, Gulec H (2016) Increased neutrophil/lymphocyte ratio in patients with depression is correlated with the severity of depression and cardiovascular risk factors. Psychiatry Invest 13(1):121

Article  CAS  Google Scholar 

Llorca-Bofí V, Palacios-Garrán R, Routo DR, Buil-Reiné E, Adrados-Pérez M, Gich I et al (2021) High neutrophil-lymphocyte ratio upon admission is associated with better response in psychotic depression. J Psychiatr Res 143:38–42

Article  PubMed  Google Scholar 

Vos CF, Birkenhäger TK, Nolen WA, van den Broek WW, Coenen MJ, Ter Hark SE et al (2021) Association of the neutrophil to lymphocyte ratio and white blood cell count with response to pharmacotherapy in unipolar psychotic depression: an exploratory analysis. Brain Behav immunity-health 16:100319

Torun F, Önder M, Torun S, Tural Ü, Şişmanlar Ş (2002) Montgomery-Asberg Depresyon Derecelendirme Ölçeği Türkçe versiyonunun özgüllüğü ve duyarliliği. 3P Dergisi.;10(3)

Ferreira SA, Pinto N, Serrenho I, Pato MV, Baltazar G (2024) Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation: a systematic review. Neural Regeneration Res 19(1):116–123

Article  CAS  Google Scholar 

Perrin AJ, Pariante CM (2020) Endocrine and immune effects of non-convulsive neurostimulation in depression: a systematic review. Brain Behav Immun 87:910–920

Article  CAS  PubMed  Google Scholar 

Adamson M, Hadipour A, Uyulan C, Erguzel T, Cerezci O, Kazemi R et al (2022) Sex differences in rTMS treatment response: a deep learning-based EEG investigation. Brain Behav 12(8):e2696

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C-T, Su T-P, Cheng C-M, Chen M-H, Bai Y-M, Tsai S-J (2022) Factors associated with antidepressant responses to repetitive transcranial magnetic stimulation in antidepressant-resistant depression. Front NeuroSci 16:1046920

Article  PubMed  PubMed Central  Google Scholar 

Mondino M, Szekely D, Bubrovszky M, Bulteau S, Downar J, Poulet E, Brunelin J (2020) Predicting treatment response to 1Hz rTMS using early self-rated clinical changes in major depression. Brain Stimul 13(6):1603–1605

Article  PubMed  Google Scholar 

Feffer K, Lee HH, Mansouri F, Giacobbe P, Vila-Rodriguez F, Kennedy SH et al (2018) Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression. Brain Stimul 11(1):181–189

Article  PubMed  Google Scholar 

Spitz NA, Pace BD, Ten Eyck P, Trapp NT (2022) Early improvement predicts clinical outcomes similarly in 10 hz rTMS and iTBS therapy for depression. Front Psychiatry 13:863225

Article  PubMed  PubMed Central  Google Scholar 

Husain MI, Foster JA, Mason BL, Chen S, Zhao H, Wang W et al (2023) Pro-inflammatory markers are associated with response to sequential pharmacotherapy in major depressive disorder: a CAN-BIND-1 report. CNS Spectr 28(6):739–746

Article  PubMed  Google Scholar 

Miller AH, Raison CL (2016) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16(1):22–34

Comments (0)

No login
gif