Abdulkadir M, Mathews CA, Scharf JM, Dongmei Yu, Tischfield JA, Heiman GA, Hoekstra PJ, Dietrich A (2019) Polygenic risk scores derived from a tourette syndrome genome-wide association study predict presence of tics in the avon longitudinal study of parents and children cohort. Biol Psychiat 85(4):298–304. https://doi.org/10.1016/j.biopsych.2018.09.011

Article  PubMed  Google Scholar 

Baldan LC, Williams KA, Gallezot J-D, Pogorelov V, Rapanelli M, Crowley M, Anderson GM et al (2014) Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice. Neuron 81(1):77–90

Article  PubMed  PubMed Central  Google Scholar 

Bloch MH, Leckman JF (2009) Clinical course of Tourette syndrome. J Psychosom Res 67(6):497–501

Article  PubMed  PubMed Central  Google Scholar 

Brandt VC, Niessen E, Ganos C, Kahl U, Bäumer T, Münchau A (2014) Altered synaptic plasticity in Tourette's syndrome and its relationship to motor skill learning. PLoS One 9(5):e98417. https://doi.org/10.1371/journal.pone.0098417

Cao X, Zhang Y, Abdulkadir M, Deng Li, Fernandez TV, Garcia-Delgar B, Hagstrøm J et al (2021) Whole-exome sequencing identifies genes associated with Tourette’s disorder in multiplex families. Mol Psychiatry. https://doi.org/10.1038/s41380-021-01094-1

Article  PubMed  PubMed Central  Google Scholar 

Channon S, Gunning A, Frankl J, Robertson MM (2006) Tourette’s syndrome (TS): cognitive performance in adults with uncomplicated TS. Neuropsychology 20(1):58–65. https://doi.org/10.1037/0894-4105.20.1.58

Article  PubMed  Google Scholar 

Chen J, Chen W, Zhao Ni, Wu MC, Schaid DJ (2016) Small sample kernel association tests for human genetic and microbiome association studies. Genet Epidemiol 40(1):5–19. https://doi.org/10.1002/gepi.21934

Article  CAS  PubMed  Google Scholar 

Davis LK, Dongmei Yu, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM et al (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9(10):e1003864

Article  PubMed  PubMed Central  Google Scholar 

Depienne Christel, Ciura Sorana, Trouillard Oriane, Bouteiller Delphine, Leitão Elsa, Nava Caroline, Keren Boris et al (2019) Association of rare genetic variants in opioid receptors with Tourette syndrome. Tremor Hyperkinetic Mov (New York, N.Y.) 9:5–5. https://doi.org/10.7916/tohm.v0.693

Article  Google Scholar 

Dijk H-V, Hilde M, van de Schoot R, Rijkeboer MM, Mathews CA, Cath DC (2016) The relationship between tics, OC, ADHD and autism symptoms: a cross-disorder symptom analysis in Gilles de la Tourette syndrome patients and their family members. Psychiatry Res 237:138–146. https://doi.org/10.1016/j.psychres.2016.01.051

Article  Google Scholar 

Eriguchi Y, Kuwabara H, Inai A, Kawakubo Y, Nishimura F, Kakiuchi C, Tochigi M et al (2017) Identification of candidate genes involved in the etiology of sporadic Tourette syndrome by exome sequencing. Am J Med Gen Part B, Neuropsychiatric Gen: Official Publ Int Soc Psychiatric Gen 174(7):712–23. https://doi.org/10.1002/ajmg.b.32559

Article  CAS  Google Scholar 

Fichna JP, Borczyk M, Piechota M, Korostynski M, Zekanowski C, Janik P (2023) Genomic variants and inferred biological processes in multiplex families with Tourette syndrome. J Psych Neurosci: JPN 48(3):E179–E189. https://doi.org/10.1503/jpn.220206

Article  Google Scholar 

Frau R, Fanni S, Serra V, Simola N, Godar SC, Traccis F, Devoto P, Bortolato M, Melis M (2019) Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress. Neuropharmacology 159:107517. https://doi.org/10.1016/j.neuropharm.2019.01.032

Article  CAS  PubMed  Google Scholar 

Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries. Dev Med Child Neurol 42(7):436–447

Article  CAS  PubMed  Google Scholar 

French JD, Edwards SL (2020) The role of noncoding variants in heritable disease. Trends Genet 36(11):880–891. https://doi.org/10.1016/j.tig.2020.07.004

Article  CAS  PubMed  Google Scholar 

Georgitsi M, Willsey AJ, Mathews CA, State M, Scharf JM, Paschou P (2016) The genetic etiology of Tourette syndrome: large-scale collaborative efforts on the precipice of discovery. Front Neurosci 10. https://doi.org/10.3389/fnins.2016.00351

Gloor FT, Walitza S (2016) Tic disorders and Tourette syndrome: current concepts of etiology and treatment in children and adolescents. Neuropediatrics 47(02):084–096

Article  Google Scholar 

Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, King RA et al (2015) Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiat 72(4):325–333

Article  Google Scholar 

Jarczak J, Grochowalski Ł, Marciniak B, Lach J, Słomka M, Sobalska-Kwapis M, Lorkiewicz W, Pułaski Ł, Strapagiel D (2019) Mitochondrial DNA variability of the Polish population. Eur J Hum Genet 27(8):1304–1314. https://doi.org/10.1038/s41431-019-0381-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaja E, Lejman A, Sielski D, Sypniewski M, Gambin T, Suchocki T, Dawidziuk M et al (2021) The thousand polish genomes project’-a national database of polish variant allele frequencies. Preprint at https://www.biorxiv.org/content/https://doi.org/10.1101/2021.07.07.451425v1.full

Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL et al (2020b) The mutational constraint spectrum quantified from variation in 141,456 humans. Nature 581(7809):434–443. https://doi.org/10.1038/s41586-020-2308-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL et al (2020a) The mutational constraint spectrum quantified from variation in 141,456 humans. Preprint at https://www.biorxiv.org/content/https://doi.org/10.1101/531210v4.full

Kawamura A, Nishiyama M (2023) Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons. Comm Biology 6(1):1–13. https://doi.org/10.1038/s42003-023-04968-y

Article  CAS  Google Scholar 

Knight T, Steeves T, Day L, Lowerison M, Jette N, Pringsheim T (2012) Prevalence of tic disorders: a systematic review and meta-analysis. Pediatr Neurol 47(2):77–90

Article  PubMed  Google Scholar 

Köhler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA, Danis D et al (2021) The human phenotype ontology in 2021. Nucleic Acids Res 49(D1):D1207–D1217

Article  PubMed  Google Scholar 

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Niels Cornelisse L et al (2019) SynGO: an evidence-based, expert-curated knowledge base for the synapse. Neuron 103(2):217-234.e4. https://doi.org/10.1016/j.neuron.2019.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale global tic severity scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psych 28(4):566–573. https://doi.org/10.1097/00004583-198907000-00015

Article  CAS  Google Scholar 

Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y-S, Peterson BS (1998) Course of tic severity in Tourette syndrome: the first two decades. Pediatrics 102(1):14–19. https://doi.org/10.1542/peds.102.1.14

Article  CAS  PubMed  Google Scholar 

Lee PH, Anttila V, Won H, Feng Y-C, Rosenthal J, Zhu Z, Tucker-Drob EM et al (2019) Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7):1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

Article  CAS  Google Scholar 

Leońska-Duniec A, Borczyk M, Korostyński M, Massidda M, Maculewicz E, Cięszczyk P (2023) Genetic variants in myostatin and its receptors promote elite athlete status. BMC Genom 24(1):761. https://doi.org/10.1186/s12864-023-09869-2

Article  CAS  Google Scholar 

Levy AM, Paschou P, Tümer Z (2021) Candidate genes and pathways associated with Gilles de la Tourette syndrome-where are we? Genes 12(9):1321. https://doi.org/10.3390/genes12091321

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao C, Vuokila V, Catoire H, Akçimen F, Ross JP, Bourassa CV, Dion PA, Meijer IA, Rouleau GA (2022) Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome. Comm Biol 5(1):289. https://doi.org/10.1038/s42003-022-03231-0

Article  Google Scholar 

Lin WD, Tsai FJ, Chou IC (2022) Current understanding of the genetics of Tourette syndrome. Biomed J 45(2):271–79. https://doi.org/10.1016/j.bj.2022.01.008

Article  CAS  PubMed