The Effect of 20-Hydroxyecdysone on the Functioning of Isolated Mouse Skeletal Muscle Mitochondria

Koolman J. 1989. Ecdysone: From chemistry of mode of action. Stuttgart: Thieme Verlag.

Google Scholar 

Toth N., Szabo A., Kacsala P., Heger J., Zador E. 2008. 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. Phytomedicine. 15 (9), 691–698.

Article  CAS  PubMed  Google Scholar 

Lafont R., Harmatha J., Marion-Poll F., Dinan L., Wilson I.D. 2002. The ecdysone handbook. 3rd ed. Prague: Cybersales.

Google Scholar 

Savchenko R.G., Veskina N.A., Odinokov V.N., Benkovskaya G.V., Parfenova L.V. 2022. Ecdysteroids: Isolation, chemical transformations, and biological activity. Phytochem. Rev. 21, 1445–1486. https://doi.org/10.1007/s11101-021-09792-y

Article  CAS  Google Scholar 

Bathori M., Toth N., Hunyadi A., Marki A., Zador E. 2008. Phytoecdysteroids and anabolic–androgenic steroids – structure and effects on humans. Curr. Med. Chem. 15, 75–91.

Article  CAS  PubMed  Google Scholar 

Slama K., Lafont R. 1995. Insect hormones—ecdysteroids: Their presence and actions in vertebrates. Eur. J. Entomol. 92, 355–377.

CAS  Google Scholar 

Dinan L., Lafont R. 2006. Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals. J. Endocrinol. 191 (1), 1–8. https://doi.org/10.1677/joe.1.06900

Article  CAS  PubMed  Google Scholar 

Slama K., Koudela K., Tenora J., Mathova A. 1996. Insect hormones in vertebrates: Anabolic effects of 20‑hydroxyecdysone in Japanese quails. Experientia. 52, 702–706.

Article  CAS  PubMed  Google Scholar 

Stopka P., Stancl J., Slama K. 1999. Effect of insect hormone, 20-hydroxyecdysone on growth and reproduction in mice. Acta Soc. Zool. Bohemicae. 63, 367–378.

Google Scholar 

Syrov V.N. 2000. Comparative experimental investigations of the anabolic activity of phytoecdysteroids and steranabols. Pharm. Chem. J. 34, 193–197.

Article  CAS  Google Scholar 

Kratky F., Opletal L., Hejhalek J., Kucharova S. 1997. Effect of 20-hydroxyecdysone on the protein synthesis of pigs. Zivocisna Vyroba. 42, 445–451.

CAS  Google Scholar 

Shuvalov O., Kirdeeva Y., Fefilova E., Netsvetay S., Zorin M., Vlasova Y., Fedorova O., Daks A., Parfenyev S., Barlev N. 2023. 20-Hydroxyecdysone confers antioxidant and antineoplastic properties in human non-small cell lung cancer cells. Metabolites. 13, 656. https://doi.org/10.3390/metabo13050656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romaniuk-Drapała A., Lisiak N., TotonE., Matysiak A., Nawrot J., Nowak G., Kaczmarek M., Rybczyńska M., Rubiś B. 2021. Proapoptotic and proautophagic activity of 20-hydroxyecdysone in breast cancer cells in vitro. Chem. Biol. Interact. 342, 109479. https://doi.org/10.1016/j.cbi.2021.109479

Article  CAS  PubMed  Google Scholar 

Xia X., Zhang Q., Liu R., Wang Z., Tang N., Liu F., Huang G., Jiang X., Gui G., Wang L., Sun X. 2014. Effects of 20-hydroxyecdysone on improving memory deficits in streptozotocin-induced type 1 diabetes mellitus in rat. Eur. J. Pharmacol. 5, 740, 45–52. https://doi.org/10.1016/j.ejphar.2014.06.026

Article  CAS  Google Scholar 

Mallek A., Movassat J., Ameddah S., Liu J., Semiane N., Khalkhal A., Dahmani Y. 2018. Experimental diabetes induced by streptozotocin in the desert gerbil, Gerbillus gerbillus, and the effects of short-term 20-hydroxyecdysone administration. Biomed. Pharmacother. 102, 354–361. https://doi.org/10.1016/j.biopha.2018.03.070

Article  CAS  PubMed  Google Scholar 

Baev A.Y., Charishnikova O.S., Khasanov F.A., Nebesnaya K.S., Makhmudov A.R., Rakhmedova M.T., Khushbaktova Z.A., Syrov V.N., Levitskaya Y.V. 2022. Ecdysterone prevents negative effect of acute immobilization stress on energy metabolism of rat liver mitochondria. J. Steroid Biochem. Mol. Biol. 219, 106066. https://doi.org/10.1016/j.jsbmb.2022.106066

Article  CAS  PubMed  Google Scholar 

Parr M.K., Botre F., Nass A., Hengevoss J., Diel P., Wolber G. 2015. Ecdysteroids: A novel class of anabolic agents? Biol. Sport. 32, 169–173.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J., Green P.S., Simpkins J.W. 2001. Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells. J. Neurochem. 77 (3), 804–811. https://doi.org/10.1046/j.1471-4159.2001.00271.x

Article  CAS  PubMed  Google Scholar 

Nilsen J., Diaz Brinton R. 2003. Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression. Proc. Natl. Acad. Sci. USA. 100 (5), 2842–2847. https://doi.org/10.1073/pnas.0438041100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burstein S.R., Kim H.J., Fels J.A., Qian L., Zhang S., Zhou P., Starkov A.A., Iadecola C., Manfredi G. 2018. Estrogen receptor beta modulates permeability transition in brain mitochondria. Biochim. Biophys. Acta. Bioenerg. 1859 (6), 423–433. https://doi.org/10.1016/j.bbabio.2018.03.006

Dubinin M.V., Ilzorkina A.I., Salimova E.V., Landage M.S., Khoroshavina E.I., Gudkov S.V., Belosludtsev K.N., Parfenova L.V. 2023. Effect of fusidic acid and some nitrogen-containing derivatives on liposomal and mitochondrial membranes. Membranes (Basel). 13 (10), 835. https://doi.org/10.3390/membranes13100835

Article  CAS  PubMed  Google Scholar 

Dubinin M.V., Nedopekina D.A., Ilzorkina A.I., Semenova A.A., Sharapov V.A., Davletshin E.V., Mikina N.V., Belsky Y.P., Spivak A.Y., Akatov V.S., Belosludtseva N.V., Liu J., Belosludtsev K.N. 2023. Conjugation of triterpenic acids of ursane and oleanane types with mitochondria-targeting cation F16 synergistically enhanced their cytotoxicity against tumor cells. Membranes (Basel). 13 (6), 563. https://doi.org/10.3390/membranes13060563

Article  CAS  PubMed  Google Scholar 

Dubinin M.V., Semenova A.A., Ilzorkina A.I., Mikheeva I.B., Yashin V.A., Penkov N.V., Vydrina V.A., Ishmuratov G.Y., Sharapov V.A., Khoroshavina E.I., Gudkov S.V., Belosludtsev K.N. 2020. Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes. Biochim. Biophys. Acta. Biomembr. 1862 (10), 183383. https://doi.org/10.1016/j.bbamem.2020.183383

Dubinin M.V., Talanov E.Y., Tenkov K.S., Starinets V.S., Mikheeva I.B., Sharapov M.G., Belosludtsev K.N. 2020. Duchenne muscular dystrophy is associated with the inhibition of calcium uniport in mitochondria and an increased sensitivity of the organelles to the calcium-induced permeability transition. Biochim. Biophys. Act-a. Mol. Basis Dis. 1866 (5), 165674. https://doi.org/10.1016/j.bbadis.2020.165674

Dubinin M.V., Svinin A.O., Vedernikov A.A., Sta-rinets V.S., Tenkov K.S., Belosludtsev K.N., Samartsev V.N. 2019. Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): Inhibition of succinate-fueled respiration and K+ transport, ROS-induced activation of mitochondrial permeability transition. J. Bioenerg. Biomembr. 51 (3), 219–229.

Article  CAS  PubMed  Google Scholar 

Chance B., Williams G.R. 1955. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J. Biol. Chem. 217 (1), 383–393.

Article  CAS  PubMed  Google Scholar 

Spinazzi M., Casarin A., Pertegato V., Salviati L., Angelini C. 2012. Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells. Nat. Protoc. 7 (6), 1235–1246. https://doi.org/10.1038/nprot.2012.058

Article  CAS  PubMed  Google Scholar 

Dubinin M.V., Sharapov V.A., Ilzorkina A.I., Efimov S.V., Klochkov V.V., Gudkov S.V., Belosludtsev K.N. 2022. Comparison of structural properties of cyclosporin A and its analogue alisporivir and their effects on mitochondrial bioenergetics and membrane behavior. Biochim. Biophys. Acta Biomembr. 864 (9), 183972.

Article  Google Scholar 

Dubinin M.V., Talanov E.Y., Tenkov K.S., Starinets V.S., Mikheeva I.B., Belosludtsev K.N. 2020. Transport of Ca2+ and Ca2+-dependent permeability transition in heart mitochondria in the early stages of Duchenne muscular dystrophy. Biochim. Biophys. Acta. Bioenergetics. 1861 (10), 148250.

Lafont R., Dinan L. 2003. Practical uses for ecdysteroids in mammals including humans: An update. J. Insect. Sci. 3, 7. https://doi.org/10.1093/jis/3.1.7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreyev A.Y., Kushnareva Y.E., Murphy A.N., Starkov A.A. 2015. Mitochondrial ROS metabolism: 10 years later. Biochemistry (Mosc.). 80 (5), 517–531.

Article  CAS  PubMed  Google Scholar 

Shchulkin A.V., Yakusheva E.N., Davydov V.V., Darmogray V.N. 2012. The study of the direct antioxidant activity of phytoecdysterone in vitro. Rossiiski med.-biol. Vestnik imeni akad. I. P. Pavlova (Rus.). 1, 51–57.

Google Scholar 

Kuzmenko A.I., Niki E., Noguchi H. 2001. New functions of 20-hydroxyecdysone in lipid peroxidation. J. Oleo Sci. 50 (6), 497–506.

CAS  Google Scholar 

Cai Y.J., Dai J.Q., Fang J.G., Ma L.P., Hou L.F., Yang L., Liu Z.L. 2002. Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata. Can. J. Physiol. Pharmacol. 80 (12), 1187–1194. https://doi.org/10.1139/y02-152

Article 

Comments (0)

No login
gif