Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum. 2009;60:3546–53.

Article  PubMed  Google Scholar 

Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res. 2016;11:19-.

Article  PubMed  PubMed Central  Google Scholar 

Glyn-Jones S, Palmer AJR, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ. Osteoarthritis. Lancet. 2015;386:376–87.

Article  CAS  PubMed  Google Scholar 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier J-P, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2010;7:33.

Article  PubMed  Google Scholar 

Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH. Identification of a central role for complement in osteoarthritis. Nat Med. 2011;17:1674.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murab S, Chameettachal S, Bhattacharjee M, Das S, Kaplan DL, Ghosh S. Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments. Tissue Eng Part A. 2013;19(15–16):1733–53. https://doi.org/10.1089/ten.tea.2012.0385.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haywood L, McWilliams DF, Pearson CI, Gill SE, Ganesan A, Wilson D, Walsh DA. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum. 2003;48:2173–7.

Article  CAS  PubMed  Google Scholar 

Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64:1263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattacharjeea M, Coburnb J, Centolacd M, Muraba S, Barberocd A, Kaplan DL, Martincd I, Ghosh S. Tissue engineering strategies to study cartilage development, degeneration and regeneration. Adv Drug Deliv Rev. 2015;84:107–22.

Article  Google Scholar 

Escobar Ivirico JL, Bhattacharjee M, Kuyinu E, Nair LS, Laurencin CT. Regenerative engineering for knee osteoarthritis treatment: biomaterials and cell-based technologies. Engineering. 2017;3(1):16–27.

Article  PubMed  Google Scholar 

Shah S, Otsuka T, Bhattacharjee M, Laurencin CT. Minimally invasive cellular therapies for osteoarthritis treatment. Regen Eng Transl Med. 2021;7:76–90.

Article  Google Scholar 

Harrell CR, Markovic BS, Fellabaum C, Arsenijevic A, Volarevic V. Mesenchymal stem cell-based therapy of osteoarthritis: current knowledge and future perspectives. Biomed Pharmacother. 2019;109:2318–26.

Article  CAS  PubMed  Google Scholar 

Narayanan G, Bhattacharjee M, Nair LS, et al. Musculoskeletal tissue regeneration: the role of the stem cells. Regen Eng Transl Med. 2017;3:133–65.

Article  Google Scholar 

Fodor PB, Paulseth SG. Adipose derived stromal cell (ADSC) injections for pain management of osteoarthritis in the human knee joint. Aesthet Surg J. 2016;36:229–36.

Article  PubMed  Google Scholar 

Daneshmandi L, Shah S, Jafari T, Bhattacharjee M, Momah D, Saveh-Shemshaki N, Lo KW-H, Laurencin CT. Emergence of the stem cell secretome in regenerative engineering. Trends Biotechnol. 38(12):1373–1384. https://doi.org/10.1016/j.tibtech.2020.04.013.

Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014;32:1254–66.

Article  CAS  PubMed  Google Scholar 

Baldari S, Di Rocco G, Piccoli M, Pozzobon M, Muraca M, Toietta G. Challenges and strategies for improving the regenerative effects of mesenchymal. Int J Mol Sci. 2017;18(10):2087. https://doi.org/10.3390/ijms18102087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vinatier C, Bouffi C, Merceron C, Gordeladze J, Brondello JM, Jorgensen C, et al. Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy. Curr Stem Cell Res Ther. 2009;4(4):318–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang K, Bae KH, Kurisawa M. Recent advances in the design of injectable hydrogels for stem cell-based therapy. J Mater Chem B. 2019;7:3775–91.

Article  CAS  Google Scholar 

Watterson JR, Esdaile JM. Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 2000;8:277–84.

Article  CAS  PubMed  Google Scholar 

Knudson CB. Hyaluronan and CD44: strategic players for cell-matrix interactions during chondrogenesis and matrix assembly. Birth Defects Res Part C - Embryo Today Rev. 2003;69:174–96.

Article  CAS  Google Scholar 

Trombino S, Servidio C, Curcio F, Cassano R. Strategies for hyaluronic acid-based hydrogel design in drug delivery. Pharmaceutics. 2019;11(8):407. https://doi.org/10.3390/pharmaceutics11080407.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antich C, Vicente J, Jiménez G, Chocarro C, Carrillo E, Montañez E, Gálvez-Martíngh P, Marchal JA. Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs. Acta Biomater. 2020;106:114–12.

Article  CAS  PubMed  Google Scholar 

Mazzocchi A, Devarasetty M, Huntwork R, Soker S, Skardal A. Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments. Biofabrication. 2018;11(1):015003. https://doi.org/10.1088/1758-5090/aae543

Law N, Doney B, Glover H, Qin Y, Aman ZM, Sercombe TB, Liew LJ, Dilley RJ, Doyle BJ. Characterisation of hyaluronic acid methylcellulose hydrogels for 3D bioprinting. J Mech Behav Biomed Mater. 2018;77:389–99.

Article  CAS  PubMed  Google Scholar 

Zhu J, Kaufman LJ. Collagen I self-assembly: revealing the developing structures that generate turbidity. Biophys J. 2014;106(8):1822–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater. 2004;71:343–54.

Article  CAS  PubMed  Google Scholar 

Radhakrishnan S, Nagarajan S, Bechelany M, Kalkura SN. Collagen based biomaterials for tissue engineering applications: a review. Cham: Springer International Publishing; 2020. p. 3–22.

Google Scholar 

Irawan V, Sung TC, Higuchi A, Ikoma T. Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development. Tissue Eng Regen Med. 2018;15(6):673–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andereya S, Maus U, Gavenis K, Muller-Rath R, Miltner O, Mumme T. First clinical experiences with a novel 3D-collagen gel (CaRes(R)) for the treatment of focal cartilage defects in the knee. Z Orthrop Ihre Grenzgev. 2006;144:272–80. https://doi.org/10.1055/s-2006-933445.

Article  CAS  Google Scholar 

Kilmer CE, Battistoni CM, Cox A, Breur GJ, Panitch A, Liu JC. Collagen type I and II blend hydrogel with autologous mesenchymal stem cells as a scaffold for articular cartilage defect repair. ACS Biomater Sci Eng. 2020;6(6):3464–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Freytes DO, Martin J, Velankar SS, Lee AS, Badylak SF. Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix. Biomaterials. 2008;29:1630–7.

Article  CAS  PubMed