Murugesan G, Sudha KM, Subaramoniam MK, et al. A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. J Indian Soc Periodontol. 2018;22(5):438–41.

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Guo S, Huang Y, et al. Inhibition of TRPA1 Ameliorates Periodontitis by Reducing Periodontal Ligament Cell Oxidative Stress and Apoptosis via PERK/eIF2α/ATF-4/CHOP Signal Pathway. Oxid Med Cell Longev. 2022;2022:4107915.

PubMed  PubMed Central  Google Scholar 

Riep B, Edesi-Neuss L, Claessen F, et al. Are putative periodontal pathogens reliable diagnostic markers? J Clin Microbiol. 2009;47(6):1705–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munenaga S, Ouhara K, Hamamoto Y, et al. The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice. Arthritis Res Ther. 2018;20(1):247.

Article  PubMed  PubMed Central  Google Scholar 

Ying S, Tan M, Feng G, et al. Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress. Theranostics. 2020;10(21):9789–807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cornacchione L P, Klein B A, Duncan M J, et al. Interspecies Inhibition of Porphyromonas gingivalis by Yogurt-Derived Lactobacillus delbrueckii Requires Active Pyruvate Oxidase. Appl Environ Microbiol, 2019, 85(18):

Jeong SH, Lee JE, Kim BB, et al. Evaluation of the effects of Cimicifugae Rhizoma on the morphology and viability of mesenchymal stem cells. Exp Ther Med. 2015;10(2):629–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oortgiesen DA, Yu N, Bronckers AL, et al. A three-dimensional cell culture model to study the mechano-biological behavior in periodontal ligament regeneration. Tissue Eng Part C Methods. 2012;18(2):81–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Wu F, Song Y, et al. Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients. Cell Death Dis. 2016;7(8): e2327.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shao Q, Liu S, Zou C, et al. Effect of LSD1 on osteogenic differentiation of human periodontal ligament stem cells in periodontitis. Oral Dis. 2023;29(3):1137–48.

Article  PubMed  Google Scholar 

Francis M, Gopinathan G, Foyle D, et al. Histone methylation: achilles heel and powerful mediator of periodontal homeostasis. J Dent Res. 2020;99(12):1332–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang MK, Mehrazarin S, Park NH, et al. Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation. Oral Dis. 2017;23(6):709–20.

Article  CAS  PubMed  Google Scholar 

Ma X, Fan C, Wang Y, et al. MiR-137 knockdown promotes the osteogenic differentiation of human adipose-derived stem cells via the LSD1/BMP2/SMAD4 signaling network. J Cell Physiol. 2020;235(2):909–19.

Article  CAS  PubMed  Google Scholar 

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–97.

Article  CAS  PubMed  Google Scholar 

Lin YP, Liao LM, Liu QH, et al. MiRNA-128-3p induces osteogenic differentiation of bone marrow mesenchymal stem cells via activating the Wnt3a signaling. Eur Rev Med Pharmacol Sci. 2021;25(3):1225–32.

PubMed  Google Scholar 

Zhang Y, Gao Y, Cai L, et al. MicroRNA-221 is involved in the regulation of osteoporosis through regulates RUNX2 protein expression and osteoblast differentiation. Am J Transl Res. 2017;9(1):126–35.

CAS  PubMed  PubMed Central  Google Scholar 

Srinaath N, Balagangadharan K, Pooja V, et al. Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells. BioFactors. 2019;45(4):575–82.

Article  CAS  PubMed  Google Scholar 

Sportoletti P, Sorcini D, Falini B. BCOR gene alterations in hematologic diseases. Blood. 2021;138(24):2455–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diao S, Yang DM, Dong R, et al. Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla. J Endod. 2015;41(2):205–11.

Article  PubMed  Google Scholar 

He S, Yang S, Zhang Y, et al. LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis. Cell Death Dis. 2019;10(12):947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui T, A P, Zhao Y, et al. EZH2, a potential regulator of dental pulp inflammation and regeneration. J Endod, 2014, 40(8): 1132–1138

Liu Z, He Y, Xu C, et al. The role of PHF8 and TLR4 in osteogenic differentiation of periodontal ligament cells in inflammatory environment. J Periodontol. 2021;92(7):1049–59.

Article  CAS  PubMed  Google Scholar 

Ge W, Liu Y, Chen T, et al. The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1. Biomaterials. 2014;35(23):6015–25.

Article  CAS  PubMed  Google Scholar 

Liang D, Song G, Zhang Z. miR-216a-3p inhibits osteogenic differentiation of human adipose-derived stem cells via Wnt3a in the Wnt/β-catenin signaling pathway. Exp Ther Med. 2022;23(4):309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geng F, Liu J, Yin C, et al. Porphyromonas gingivalis lipopolysaccharide induced RIPK3/MLKL-mediated necroptosis of oral epithelial cells and the further regulation in macrophage activation. J Oral Microbiol. 2022;14(1):2041790.

Article  PubMed  PubMed Central  Google Scholar 

Riccia DN, Bizzini F, Perilli MG, et al. Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease. Oral Dis. 2007;13(4):376–85.

Article  PubMed  Google Scholar 

Han N, Zhang F, Li G, et al. Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche. Stem Cell Res Ther. 2017;8(1):210.

Article  PubMed  PubMed Central  Google Scholar 

Yang YT, Wang X, Zhang YY, et al. The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis. Cell Death Dis. 2019;10(4):278.

Article  PubMed  PubMed Central  Google Scholar 

Marques-Rocha JL, Samblas M, Milagro FI, et al. Noncoding RNAs, cytokines, and inflammation-related diseases. Faseb J. 2015;29(9):3595–611.

Article  CAS  PubMed  Google Scholar 

Liu J, Chen B, Yan F, et al. The Influence of inflammatory cytokines on the proliferation and osteoblastic differentiation of MSCs. Curr Stem Cell Res Ther. 2017;12(5):401–8.

Article  PubMed  Google Scholar 

Jingjing W, Zhikai W, Xingyi Z, et al. Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis. Int Immunopharmacol. 2021;91: 107324.

Article  PubMed  Google Scholar 

Wang Q, Xie X, Zhang D, et al. Saxagliptin enhances osteogenic differentiation in MC3T3-E1 cells, dependent on the activation of AMP-activated protein kinase α (AMPKα)/runt-related transcription factor-2 (Runx-2). Bioengineered. 2022;13(1):431–9.

Article  PubMed  PubMed Central