Inhibition of DCUN1D1 attenuates periodontitis by suppressing NF-κB signaling

Kwon T, Lamster IB, Levin L. current concepts in the management of periodontitis. Int Dent J. 2021;71:462–76.

Article  PubMed  PubMed Central  Google Scholar 

Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nazir M, Al-Ansari A, Al-Khalifa K, et al. Global prevalence of periodontal disease and lack of its surveillance. Sci World J. 2020;2020:2146160.

Article  Google Scholar 

Yadalam PK, Kalaivani V, Fageeh HI, et al. Future drug targets in periodontal personalised medicine-a narrative review. J Pers Med. 2022. https://doi.org/10.3390/jpm12030371.

Article  PubMed  PubMed Central  Google Scholar 

Cardoso EM, Reis C, Manzanares-Cespedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgrad Med. 2018;130:98–104.

Article  PubMed  Google Scholar 

Nichols TC, Fischer TH, Deliargyris EN, Baldwin AS Jr. Role of nuclear factor-kappa B (NF-kappa B) in inflammation, periodontitis, and atherogenesis. Ann Periodontol. 2001;6:20–9.

Article  CAS  PubMed  Google Scholar 

Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017. https://doi.org/10.1038/sigtrans.2017.23.

Article  PubMed  PubMed Central  Google Scholar 

Afacan B, Ozturk VO, Pasali C, et al. Gingival crevicular fluid and salivary HIF-1alpha, VEGF, and TNF-alpha levels in periodontal health and disease. J Periodontol. 2019;90:788–97.

Article  CAS  PubMed  Google Scholar 

Costa PP, Trevisan GL, Macedo GO, et al. Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol. 2010;81:384–91.

Article  CAS  PubMed  Google Scholar 

Wang J, Wu S, Li Z, et al. Inhibition of nuclear factor kappa B inducing kinase suppresses inflammatory responses and the symptoms of chronic periodontitis in a mouse model. Int J Biochem Cell Biol. 2021;139: 106052.

Article  CAS  PubMed  Google Scholar 

Apolinario Vieira GH, Aparecida Rivas AC, Figueiredo Costa K, et al. Specific inhibition of IL-6 receptor attenuates inflammatory bone loss in experimental periodontitis. J Periodontol. 2021;92:1460–9.

Article  CAS  PubMed  Google Scholar 

Yuan J, Wang X, Ma D, et al. Resveratrol rescues TNF-alpha-induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway. Mol Med Rep. 2020;21:2085–94.

CAS  PubMed  PubMed Central  Google Scholar 

Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998;160:403–9.

Article  CAS  PubMed  Google Scholar 

Yao J, Liang X, Liu Y, Zheng M. Neddylation: a versatile pathway takes on chronic liver diseases. Front Med. 2020;7:586881.

Article  Google Scholar 

Rabut G, Peter M. Function and regulation of protein neddylation. “Protein modifications: beyond the usual suspects” review series. EMBO Rep. 2008;9:969–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ehrentraut SF, Curtis VF, Wang RX, et al. Perturbation of neddylation-dependent NF-kappaB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation. Mol Biol Cell. 2016;27:3687–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim AY, Bommeljé CC, Lee BE, et al. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. J Biol Chem. 2008;283:33211–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Q, Chen X, Chen B. MicroRNA-3148 inhibits glioma by decreasing DCUN1D1 and inhibiting the NF-kB pathway. Exp Ther Med. 2022;23:28.

Article  PubMed  Google Scholar 

Chen Q, Su J, Chen X. Role of ubiquitin-specific protease 5 in the inflammatory response of chronic periodontitis. Oral Dis. 2023;29:1234–41.

Article  PubMed  Google Scholar 

Pang Y, Liu L, Wu S, Wang J, Liu L. Synoviolin alleviates GSDMD-mediated periodontitis by suppressing its stability. Immun Inflamm Dis. 2023;11:e880.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Xia D. Activation of local innate immune signal induces periodontitis in microbiota-dependent manner. FEMS Microbiol Lett. 2019. https://doi.org/10.1093/femsle/fnz147.

Article  PubMed  Google Scholar 

Kim HS, Hammill JT, Scott DC, et al. Discovery of novel pyrazolo-pyridone DCN1 inhibitors controlling cullin neddylation. J Med Chem. 2019;62:8429–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paul O, Arora P, Mayer M, Chatterjee S. Inflammation in periodontal disease: possible link to vascular disease. Front Physiol. 2020;11: 609614.

Article  PubMed  Google Scholar 

Kim JY, Kim KR, Kim HN. The Potential impact of salivary IL-1 on the diagnosis of periodontal disease: A pilot study. Healthcare. 2021;9(6):729.

Article  PubMed  PubMed Central  Google Scholar 

Luo G, Li F, Li X, Wang ZG, Zhang B. TNF-alpha and RANKL promote osteoclastogenesis by upregulating RANK via the NF-kappaB pathway. Mol Med Rep. 2018;17:6605–11.

CAS  PubMed  PubMed Central  Google Scholar 

Zamri F, de Vries TJ. Use of TNF inhibitors in rheumatoid arthritis and implications for the periodontal status: for the benefit of both? Front Immunol. 2020;11:591365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nolde M, Alayash Z, Reckelkamm SL, et al. Downregulation of interleukin 6 signaling might reduce the risk of periodontitis: a drug target Mendelian randomization study. Front Immunol. 2023;14:1160148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1:a001651.

Article  PubMed  PubMed Central  Google Scholar 

Arabaci T, Cicek Y, Canakci V, et al. Immunohistochemical and Stereologic analysis of NF-kappaB activation in chronic periodontitis. Eur J Dent. 2010;4:454–61.

PubMed  PubMed Central  Google Scholar 

Du Y, Liu X, Xiao C, et al. TIPE2 regulates periodontal inflammation by inhibiting NF-kappaB p65 phosphorylation. J Appl Oral Sci. 2023;31:e20230162.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong G, Ji W, Wang F, et al. Quercetin inhibits inflammatory response induced by LPS from porphyromonas gingivalis in human gingival fibroblasts via suppressing NF-kappaB signaling pathway. Biomed Res Int. 2019;2019:6282635.

Article  PubMed  PubMed Central  Google Scholar 

Fan L, Li Z, Gao L, Zhang N, Chang W. Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-kappaB pathways. Open Life Sci. 2023;18:20220541.

Article  CAS 

Comments (0)

No login
gif