Abdulrahman H, Fletcher PC, Bullmore E, Morcome AM (2017) Dopamine and memory dedifferentiation in aging. Neuroimage 153:211–220
Article CAS PubMed Google Scholar
Badshah H, Kim TH, Kim MJ, Ahmad A, Kim MO (2014) Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex. Neurochem Int 74:8–15
Article CAS PubMed Google Scholar
Borgemeester RWK, Van Laar T (2017) Continuous subcutaneous apomorphine infusion in Parkinson’s disease patients with cognitive dysfunction: a retrospective long-term follow-up study. Parkinsonism Relat Disord 45:33–38
Bradley-Whitman MA, Lovell MA (2015) Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update. Arch Toxicol 89:1035–1044
Article CAS PubMed PubMed Central Google Scholar
Burruss JW, Hurley RA, Taber KH, Rauch RA, Norton RE, Hayman LA (2000) Functional neuroanatomy of the frontal lobe circuits. Radiology 214:227–230
Article CAS PubMed Google Scholar
Castri P, Busceti C, Battaglia G, Girardi F, Cavallari M, Orzi F, Fornai F (2006) Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents. Clin Exp Hypertens 28:387–394
Article CAS PubMed Google Scholar
Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Collin F (2018) Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox Biol 14:450–464
Article CAS PubMed Google Scholar
Chidambara-Murthy KN, Jayaprakasha GK, Singh RP (2002) Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem 50:4791–4795
Chow CK, Tappel AL (1971) An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7:518–524
de Mello Bastos JM, Dias FR, Alves VH, Carey RJ, Carrera MP (2014) Drug memory substitution during re-consolidation: a single inhibitory autoreceptor apomorphine treatment given during psychostimulant memory re-consolidation replaces psychostimulant conditioning with conditioned inhibition and reverses psychostimulant sensitization. Behav Brain Res 260:139–147
Deshmukh R, Kaundal M, Bansal V, Samardeep, (2016) Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats. Biomed Pharmacother 81:56–62
Article CAS PubMed Google Scholar
Ellman GL, Courtney KD, AndresV FRM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95
Article CAS PubMed Google Scholar
Flatt JD, Gilsanz P, Quesenberry CP, Albers KB, Whitmer RA (2018) Post-traumatic stress disorder and risk of dementia among members of a health care delivery system. Alz Dem 14:28–34
Flohe L, Gunzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114–121
Fornai F, Battaglia G, Gesi M, Orzi F, Ruggieri S (2001) Dose-dependent protective effects of apomorphine against methamphetamine-induced nigrostriatal damage. Brain Res 898:27–35
Article CAS PubMed Google Scholar
Grunblatt E, Mandel S, Maor G, Youdim MB (2001) Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss. J Neurochem 77:146–156
Guadagno NA, Moriconi C, Licursi V, D’Acunto E, Nisi PS, Carucci N, De Jaco A, Cacci E, Negria R, Lupod G, Mirandaae E (2017) Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB. Neurobiol Dis 103:32–44
Hanaki M, Murakami K, Katayama S, Akagi K-I, Irie K (2018) Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine. Bioorg Med Chem. https://doi.org/10.1016/j.bmc.2018.01.028
Hartl D, Schuldt V, Forler S, Zabel C, Klose J, Rohe M (2012) Presymptomatic alterations in energy metabolism and oxidative stress in the APP23 mouse model of Alzheimer disease. J Prot Res 11:3295–3304
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J (2011) Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation. Ann Neurol 69:248–256
Article CAS PubMed Google Scholar
Ikram H, Zakir R, Haleem DJ (2011) Effects of single administration of apomorphine on memory and monoamine metabolism: a dose related study. Pak J Pharm Sci 31:439–445
Ikram H, Zakir R, Haleem DJ (2018) Effects of single administration of apomorphine on memory and monoamine metabolism: a dose related study. Pak J Pharm Sci 31(2):439–445
Ikram H, Tasneem S, Perveen S, Zakir R, Haleem DJ (2021) Neurochemical and behavioral effects of fluoxetine on midazolam induce dependence in an animal model of addiction. Pak J Pharm Sci 34(5):1749–1757
Ikram H, Masood R, Syed S, Haleem DJ (2023) Neuropharmacological studies on repurposed utilization of pioglitazone in learning and memory: a dose related study. Pak J Pharm Sci 36(4):1159–1167
Ikram H, Haleem DJ (2019) Repeated treatment with a low dose of reserpine as a progressive model of Parkinson’s dementia. Pak J Pharm Sci (Impact Factor: 0.95) 32(2):555–562
Jung JH, An K, Kwon OB, Kim H, Kim J-H (2011) Pathway-specific alteration of synaptic plasticity in Tg2576 mice. Mol Cells 32:197–201
Article CAS PubMed PubMed Central Google Scholar
Kumar A, Singh N (2017) Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer’s type. Biomed Pharmacoth 88:698–707
Li R, Singh M (2014) Sex differences in cognitive impairment and Alzheimer’s disease. Front Neuroendocrinol 35:385–403
Article PubMed PubMed Central Google Scholar
Lisman JE, Grace AA (2005) The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 46:703–713
Article CAS PubMed Google Scholar
Morelira PI, Smith MA, Zhu X, Santos MS, Oliveira CR, Perry G (2004) Therapeutic potential of oxidant mechanisms in Alzheimer’s disease. Expert Rev Neurother 4:995–1004
Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, Shirasawa T, Shimizu T (2011) OD1 (Copper/Zinc Superoxide Dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of alzheimer disease. J Biol Chem 286:44557–44568
Article CAS PubMed PubMed Central Google Scholar
Neugroschl J, Wang S (2011) Alzheimer’s disease: diagnosis and treatment across the spectrum of disease severity. Mt Sinai J Med 78:596–612
Article PubMed PubMed Central Google Scholar
Nobili A, Latagliata EC, Viscomi MT, Cavallucci V, Cutuli D, Giacovazzo G, Krashia P, Rizzo FR, Marino R, Federici M, De Bartolo P, Aversa D, Dell’Acqua MC, Cordella A, Sancandi M, Keller F, Petrosini L, Puglisi-Allegra S, Mercuri NB, Coccurello R, Berretta N, D’Amelio M (2017) Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease. Nature Comm. https://doi.org/10.1038/ncomms14727
Pinheiro M, Carey RJ, Cruz Dias FR, de Mattos LW (2012) Memory re-consolidation and drug conditioning: an apomorphine conditioned locomotor stimulant response can be enhanced or reversed by a single high versus low apomorphine post-trial treatment. Psychopharmacology 220:281–291
Riedel G, Kang SH, Choi DY, Platt B (2009) Scopolamine-induced deficits in social memory in mice: reversal by donepezil. Behav Brain Res 204:217–225
Article CAS PubMed Google Scholar
Rosa-Grilo M, Qamar MA, As E, Chaudhuri KR (2016) The efficacy of apomorphine – a non-motor perspective. Park Rel Disord 33:28–35
Sandhir R, Yadav A, Sunkaria A, Singhal N (2015). Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions. Neurochem Int 89(1): 209–226
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