Lamont, R. J., Koo, H. & Hajishengallis, G. The oral microbiota: dynamic communities and host interactions. Nat. Rev. Microbiol. 16, 745–759 (2018).
Article CAS PubMed PubMed Central Google Scholar
Papapanou, P. N. et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol. 89, S173–S182 (2018).
Torres, A. et al. Proteomic profile of human gingival crevicular fluid reveals specific biological and molecular processes during clinical progression of periodontitis. J. Periodontal. Res. https://doi.org/10.1111/jre.13169 (2023).
Dixon, S. J. et al. Ferroptosis: An Iron-Dependent Form of Nonapoptotic. Cell Death. Cell 149, 1060–1072 (2012).
Amaral, E. P. et al. A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis. J. Exp. Med. 216, 556–570 (2019).
Article CAS PubMed PubMed Central Google Scholar
Dar, H. H. et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J. Clin. Investig. 128, 4639–4653 (2018).
Article PubMed PubMed Central Google Scholar
Pajuelo, D. et al. NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis. Cell Rep. 24, 429–440 (2018).
Article CAS PubMed PubMed Central Google Scholar
Wei, S. et al. Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clin. Transl. Med. 10, e173 (2020).
do Van, B. et al. Ferroptosis, a newly characterized form of cell death in Parkinson’s disease that is regulated by PKC. Neurobiol. Dis. 94, 169–178 (2016).
Hassannia, B., Vandenabeele, P. & vanden Berghe, T. Targeting Ferroptosis to Iron Out Cancer. Cancer Cell 35, 830–849 (2019).
Article CAS PubMed Google Scholar
Sun, Y. et al. The emerging role of ferroptosis in inflammation. Biomed. Pharmacother. 127, 110108 (2020).
Article CAS PubMed Google Scholar
Weiland, A. et al. Ferroptosis and Its Role in Diverse Brain Diseases. Mol. Neurobiol. 56, 4880–4893 (2019).
Article CAS PubMed Google Scholar
Boyer, E. et al. Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis. Sci. Rep. 8, 15532 (2018).
Article PubMed PubMed Central Google Scholar
Guo, L.-N., Yang, Y.-Z. & Feng, Y.-Z. Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus. BMC Oral. Health 18, 63 (2018).
Article PubMed PubMed Central Google Scholar
Mukherjee, S. The Role of Crevicular Fluid Iron in Periodontal Disease. J. Periodontol. 56, 22–27 (1985).
Article CAS PubMed Google Scholar
Bains, R. & Bains, V. The antioxidant master glutathione and periodontal health. Dent. Res J. 12, 389 (2015).
Grant, M. M., Brock, G. R., Matthews, J. B. & Chapple, I. L. C. Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy. J. Clin. Periodontol. 37, 17–23 (2010).
Article CAS PubMed Google Scholar
Wang, Y., Andrukhov, O. & Rausch-Fan, X. Oxidative Stress and Antioxidant System in Periodontitis. Front. Physiol. 8, 910 (2017).
Xing, L. et al. Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss. Int Immunopharmacol. 114, 109607 (2023).
Article CAS PubMed Google Scholar
Fu, E. et al. Role of ferroptosis in periodontitis: An animal study in rats. J. Periodontal Res. 58, 1031–1040 (2023).
Article CAS PubMed Google Scholar
Wong, S. L. & Wagner, D. D. Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging. FASEB J. 32, 6258–6370 (2018).
Li, P. et al. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207, 1853–1862 (2010).
Article CAS PubMed PubMed Central Google Scholar
Koopman, G. et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 1415–1420 (1994).
Article CAS PubMed Google Scholar
Vermes, I., Haanen, C., Steffens-Nakken, H. & Reutellingsperger, C. A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184, 39–51 (1995).
Article CAS PubMed Google Scholar
Leppilahti, J. M., Kallio, M. A., Tervahartiala, T., Sorsa, T. & Mäntylä, P. Gingival Crevicular Fluid Matrix Metalloproteinase-8 Levels Predict Treatment Outcome Among Smokers With Chronic Periodontitis. J. Periodontol. 85, 250–260 (2014).
Article CAS PubMed Google Scholar
Hernández, M. et al. Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study. J. Periodontol. 81, 1644–1652 (2010).
Sorsa, T. et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontology 70, 142–163 (2016).
Baeza, M. et al. Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study. J. Clin. Periodontol. 43, 34–45 (2016).
Article CAS PubMed Google Scholar
Tymkiw, K. D. et al. Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis. J. Clin. Periodontol. 38, 219–228 (2011).
Article CAS PubMed Google Scholar
Hernández, M. et al. MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients’, Mild and Severe Periodontitis Sites. Biomolecules 10, 1500 (2020).
Article PubMed PubMed Central Google Scholar
Teles, R. et al. Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss. J. Clin. Periodontol. 45, 15–25 (2018).
Teles, R. P., Patel, M., Socransky, S. S. & Haffajee, A. D. Disease Progression in Periodontally Healthy and Maintenance Subjects. J. Periodontol. 79, 784–794 (2008).
Article CAS PubMed Google Scholar
Teles, R. et al. Modelling changes in clinical attachment loss to classify periodontal disease progression. J. Clin. Periodontol. 43, 426–434 (2016).
Article PubMed PubMed Central Google Scholar
Papapanou, P. N., Wennström, J. L. & Gröndahl, K. A 10–year retrospective study of periodontal disease progression. J. Clin. Periodontol. 16, 403–411 (1989).
Article CAS PubMed Google Scholar
Schätzle, M. et al. Clinical course of chronic periodontitis. J. Clin. Periodontol. 30, 909–918 (2003).
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