Body composition and body fat distribution in tissue-specific insulin resistance and in response to a 12-week isocaloric dietary macronutrient intervention

Goossens GH. The metabolic phenotype in obesity: Fat Mass, Body Fat distribution, and adipose tissue function. Obes Facts. 2017;10(3):207–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez-Ambrosi J, Silva C, Galofre JC, Escalada J, Santos S, Gil MJ, et al. Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI. Obes (Silver Spring). 2011;19(7):1439–44.

Article  Google Scholar 

Blaak EE. Current metabolic perspective on malnutrition in obesity: towards more subgroup-based nutritional approaches? Proc Nutr Soc. 2020:1–7.

Gomez-Ambrosi J, Silva C, Galofre JC, Escalada J, Santos S, Millan D, et al. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes (Lond). 2012;36(2):286–94.

Article  CAS  PubMed  Google Scholar 

Linge J, Borga M, West J, Tuthill T, Miller MR, Dumitriu A, et al. Body composition profiling in the UK Biobank Imaging Study. Obes (Silver Spring). 2018;26(11):1785–95.

Article  CAS  Google Scholar 

Kusters YH, Schalkwijk CG, Houben AJ, Kooi ME, Lindeboom L, ‘t Op J et al. Independent tissue contributors to obesity-associated insulin resistance. JCI Insight. 2017;2(13).

Muller MJ, Lagerpusch M, Enderle J, Schautz B, Heller M, Bosy-Westphal A. Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome. Obes Rev. 2012;13(Suppl 2):6–13.

Article  PubMed  Google Scholar 

Tejani S, McCoy C, Ayers CR, Powell-Wiley TM, Despres JP, Linge J et al. Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank. Mayo Clin Proc. 2021.

Trouwborst I, Bowser SM, Goossens GH, Blaak EE. Ectopic Fat Accumulation in distinct insulin resistant phenotypes; targets for Personalized Nutritional interventions. Front Nutr. 2018;5:77.

Article  PubMed  PubMed Central  Google Scholar 

Goossens GH, Jocken JWE, Blaak EE. Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver. Nat Rev Endocrinol. 2021;17(1):47–66.

Article  PubMed  Google Scholar 

Goss AM, Goree LL, Ellis AC, Chandler-Laney PC, Casazza K, Lockhart ME, et al. Effects of diet macronutrient composition on body composition and fat distribution during weight maintenance and weight loss. Obes (Silver Spring). 2013;21(6):1139–42.

Article  Google Scholar 

Gower BA, Goss AM. A lower-carbohydrate, higher-fat diet reduces abdominal and intermuscular fat and increases insulin sensitivity in adults at risk of type 2 diabetes. J Nutr. 2015;145(1):S177–83.

Article  Google Scholar 

Haghighat N, Ashtary-Larky D, Bagheri R, Mahmoodi M, Rajaei M, Alipour M, et al. The effect of 12 weeks of euenergetic high-protein diet in regulating appetite and body composition of women with normal-weight obesity: a randomised controlled trial. Br J Nutr. 2020;124(10):1044–51.

Article  CAS  PubMed  Google Scholar 

Wali JA, Solon-Biet SM, Freire T, Brandon AE. Macronutrient determinants of obesity, Insulin Resistance and metabolic health. Biology (Basel). 2021;10(4).

Trouwborst I, Gijbels A, Jardon KM, Siebelink E, Hul GB, Wanders L, et al. Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: a precision nutrition trial. Cell Metab. 2023;35(1):71–e835.

Article  CAS  PubMed  Google Scholar 

Gijbels A, Trouwborst I, Jardon KM, Hul GB, Siebelink E, Bowser SM, et al. The PERSonalized glucose optimization through nutritional intervention (PERSON) study: Rationale, Design and preliminary Screening results. Front Nutr. 2021;8:694568.

Article  PubMed  PubMed Central  Google Scholar 

Schram MT, Sep SJ, van der Kallen CJ, Dagnelie PC, Koster A, Schaper N, et al. The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. Eur J Epidemiol. 2014;29(6):439–51.

Article  PubMed  Google Scholar 

Linge J, Whitcher B, Borga M, Dahlqvist Leinhard O. Sub-phenotyping metabolic disorders using body composition: an Individualized, Nonparametric Approach Utilizing Large Data Sets. Obes (Silver Spring). 2019;27(7):1190–9.

Article  CAS  Google Scholar 

Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22(9):1462–70.

Article  CAS  PubMed  Google Scholar 

Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 2007;30(1):89–94.

Article  CAS  PubMed  Google Scholar 

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.

Article  CAS  PubMed  Google Scholar 

Lundsgaard AM, Kiens B. Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity. Front Endocrinol (Lausanne). 2014;5:195.

Article  PubMed  Google Scholar 

Hoeg L, Roepstorff C, Thiele M, Richter EA, Wojtaszewski JF, Kiens B. Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling. J Appl Physiol (1985). 2009;107(3):824–31.

Article  PubMed  Google Scholar 

Paul S, Thomas G, Majeed A, Khunti K, Klein K. Women develop type 2 diabetes at a higher body mass index than men. Diabetologia. 2012;55(5):1556–7.

Article  CAS  PubMed  Google Scholar 

de Ritter R, Sep SJS, van der Kallen CJH, Schram MT, Koster A, Kroon AA, et al. Adverse differences in cardiometabolic risk factor levels between individuals with pre-diabetes and normal glucose metabolism are more pronounced in women than in men: the Maastricht Study. BMJ Open Diabetes Res Care. 2019;7(1):e000787.

Article  PubMed  PubMed Central  Google Scholar 

Perseghin G, Scifo P, Pagliato E, Battezzati A, Benedini S, Soldini L, et al. Gender factors affect fatty acids-induced insulin resistance in nonobese humans: effects of oral steroidal contraception. J Clin Endocrinol Metab. 2001;86(7):3188–96.

CAS  PubMed  Google Scholar 

Bredella MA. Sex differences in body composition. Adv Exp Med Biol. 2017;1043:9–27.

Article  CAS  PubMed  Google Scholar 

Wells JC. Sexual dimorphism of body composition. Best Pract Res Clin Endocrinol Metab. 2007;21(3):415–30.

Article  PubMed  Google Scholar 

Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on visceral obesity. Nat Rev Endocrinol. 2020;16(3):177–89.

Article  PubMed  PubMed Central  Google Scholar 

Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F. The pathophysiology of abdominal adipose tissue depots in health and disease. Horm Mol Biol Clin Investig. 2014;19(1):57–74.

Article  CAS  PubMed  Google Scholar 

Kwon HW, Lee SM, Lee JW, Oh JE, Lee SW, Kim SY. Association between volume and glucose metabolism of abdominal adipose tissue in healthy population. Obes Res Clin Pract. 2017;11(5 Suppl 1):133–43.

Article  PubMed  Google Scholar 

Amato MC, Guarnotta V, Giordano C. Body composition assessment for the definition of cardiometabolic risk. J Endocrinol Invest. 2013;36(7):537–43.

CAS  PubMed  Google Scholar 

Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, et al. Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obes (Silver Spring). 2013;21(9):E439–47.

Article  CAS  Google Scholar 

Stinkens R, Goossens GH, Jocken JW, Blaak EE. Targeting fatty acid metabolism to improve glucose metabolism. Obes Rev. 2015;16(9):715–57.

Article  CAS  PubMed  Google Scholar 

Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, et al. Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome–LIPGENE: a European randomized dietary intervention study. Int J Obes (Lond). 2011;35(6):800–9.

Article  CAS  PubMed  Google Scholar 

Blanco-Rojo R, Alcala-Diaz JF, Wopereis S, Perez-Martinez P, Quintana-Navarro GM, Marin C, et al. The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial. Diabetologia. 2016;59(1):67–76.

Article  CAS  PubMed  Google Scholar 

Takahashi F, Hashimoto Y, Kaji A, Sakai R, Kawate Y, Okamura T, et al. Dietary Fiber intake is related to skeletal muscle Mass, Body Fat Mass, and muscle-to-Fat ratio among people with type 2 diabetes: a cross-sectional study. Front Nutr. 2022;9:881877.

Article  PubMed  PubMed Central  Google Scholar 

Breneman CB, Tucker L. Dietary fibre consumption and insulin resistance - the role of body fat and physical activity. Br J Nutr. 2013;110(2):375–83.

Article  CAS  PubMed  Google Scholar 

Gilbert JA, Bendsen NT, Tremblay A, Astrup A. Effect of proteins from different sources on body composition. Nutr Metab Cardiovasc Dis. 2011;21(Suppl 2):B16–31.

Article  CAS  PubMed  Google Scholar 

Borga M, West J, Bell JD, Harvey NC, Romu T, Heymsfield SB, et al. Advanced body composition assessment: from body mass index to body composition profiling. J Investig Med. 2018;66(5):1–9.

Article  PubMed  PubMed Central  Google Scholar 

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