In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma

Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS statistical report: primary brain and other central nervous system tumours diagnosed in the United States in 2014–2018. Neuro Oncol 23(12 Suppl 2):31–3105. https://doi.org/10.1093/neuonc/noab200

Article  Google Scholar 

GLOBAL ISSUES: Population. WHO. https://www.un.org/es/global-issues/population. Accessed 1 September 2023

GBD (2016) Brain and Other CNS Cancer Collaborators (2019) Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(4):376–393. https://doi.org/10.1016/S1474-4422(18)30468-X

Article  Google Scholar 

Grech N, Dalli T, Mizzi S, Meilak L, Calleja N, Zrinzo A (2020) Rising incidence of glioblastoma multiforme in a well-defined population. Cureus 12(5):e8195. https://doi.org/10.7759/cureus.8195

Article  PubMed  PubMed Central  Google Scholar 

Cantidio FS, Gil GOB, Queiroz IN, Regalin M (2022) Glioblastoma: treatment and obstacles. Rep Pract Oncol Radiother 27(4):744–753. https://doi.org/10.5603/RPOR.a2022.0076

Article  PubMed  PubMed Central  Google Scholar 

Walsh LE, Polacek LC, Panageas K, Reiner A, Walbert T, Thomas AA, Buthorn J, Sigler A, Prigerson HG, Applebaum AJ, Diamond EL (2022) Coping with glioblastoma: prognostic communication and prognostic understanding among patients with recurrent glioblastoma, caregivers, and oncologists. J Neurooncol 158(1):69–79. https://doi.org/10.1007/s11060-022-04010-x

Article  PubMed  PubMed Central  Google Scholar 

Rong L, Li N, Zhang Z (2022) Emerging therapies for glioblastoma: current state and future directions. J Exp Clin Cancer Res 41(1):142. https://doi.org/10.1186/s13046-022-02349-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gatto L, Di Nunno V, Franceschi E, Tosoni A, Bartolini S, Brandes AA (2022) Pharmacotherapeutic treatment of glioblastoma: where are we to date? Drugs 82(5):491–510. https://doi.org/10.1007/s40265-022-01702-6

Article  PubMed  Google Scholar 

Birzu C, French P, Caccese M, Cerretti G, Idbaih A, Zagonel V, Lombardi G (2020) Recurrent glioblastoma: from molecular landscape to new treatment perspectives. Cancers (Basel) 13(1):47. https://doi.org/10.3390/cancers13010047

Article  CAS  PubMed  Google Scholar 

Duffau H (2012) The challenge to remove diffuse low-grade gliomas while preserving brain functions. Acta Neurochir (Wien) 154(4):569–574. https://doi.org/10.1007/s00701-012-1275-7

Article  PubMed  Google Scholar 

Lu VM, Jue TR, McDonald KL, Rovin RA (2018) The survival effect of repeat surgery at glioblastoma recurrence and its trend: a systematic review and meta-analysis. World Neurosurg 115:453-459.e3. https://doi.org/10.1016/j.wneu.2018.04.016

Article  PubMed  Google Scholar 

You H, Qiao H (2021) Intraoperative neuromonitoring during resection of gliomas involving eloquent areas. Front Neurol 12:658680. https://doi.org/10.3389/fneur.2021.658680

Article  PubMed  PubMed Central  Google Scholar 

Janjua TI, Rewatkar P, Ahmed-Cox A, Saeed I, Mansfeld FM, Kulshreshtha R, Kumeria T, Ziegler DS, Kavallaris M, Mazzieri R, Popat A (2021) Frontiers in the treatment of glioblastoma: past, present and emerging. Adv Drug Deliv Rev 171:108–138. https://doi.org/10.1016/j.addr.2021.01.012

Article  CAS  PubMed  Google Scholar 

Giakoumettis D, Kritis A, Foroglou N (2018) C6 cell line: the gold standard in glioma research. Hippokratia 22(3):105–112

CAS  PubMed  PubMed Central  Google Scholar 

Gieryng A, Pszczolkowska D, Bocian K, Dabrowski M, Rajan WD, Kloss M, Mieczkowski J, Kaminska B (2017) Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas. Sci Rep 7(1):17556. https://doi.org/10.1038/s41598-017-17752-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brioschi A, Zenga F, Zara GP, Gasco MR, Ducati A, Mauro A (2007) Solid lipid nanoparticles: could they help to improve the efficacy of pharmacologic treatments for brain tumours? Neurol Res 29(3):324–330. https://doi.org/10.1179/016164107X187017

Article  CAS  PubMed  Google Scholar 

Jnaidi R, Almeida AJ, Gonçalves LM (2020) Solid lipid nanoparticles and nanostructured lipid carriers as smart drug delivery systems in the treatment of glioblastoma multiforme. Pharmaceutics 12(9):860. https://doi.org/10.3390/pharmaceutics12090860

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aparicio-Blanco J, Sanz-Arriazu L, Lorenzoni R, Blanco-Prieto MJ (2020) Glioblastoma chemotherapeutic agents used in the clinical setting and in clinical trials: nanomedicine approaches to improve their efficacy. Int J Pharm 581:119283. https://doi.org/10.1016/j.ijpharm.2020.119283

Article  CAS  PubMed  Google Scholar 

Formica JV, Regelson W (1995) Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol 33(12):1061–1080. https://doi.org/10.1016/0278-6915(95)00077-1

Article  CAS  PubMed  Google Scholar 

Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Li RM, Chen JY, Feng JB, Yuan SH, Ye F (2012) Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Int J Nanomed 7:271–280. https://doi.org/10.2147/IJN.S26935

Article  CAS  Google Scholar 

Ersoz M, Erdemir A, Derman S, Arasoglu T, Mansuroglu B (2020) Quercetin-loaded nanoparticles enhance cytotoxicity and antioxidant activity on C6 glioma cells. Pharm Dev Technol 25(6):757–766. https://doi.org/10.1080/10837450.2020.1740933

Article  CAS  PubMed  Google Scholar 

Wang G, Wang J, Luo J, Wang L, Chen X, Zhang L, Jiang S (2013) PEG2000-DPSE-coated quercetin nanoparticles remarkably enhanced anticancer effects through induced programed cell death on C6 glioma cells. J Biomed Mater Res A 101(11):3076–3085. https://doi.org/10.1002/jbm.a.34607

Article  CAS  PubMed  Google Scholar 

Zang X, Cheng M, Zhang X, Chen X (2021) Quercetin nanoformulations: a promising strategy for tumour therapy. Food Funct 12(15):6664–6681. https://doi.org/10.1039/d1fo00851j

Article  CAS  PubMed  Google Scholar 

Davidescu M, Macchioni L, Scaramozzino G, Cristina Marchetti M, Migliorati G, Vitale R, Corcelli A, Roberti R, Castigli E, Corazzi L (2015) The energy blockers bromopyruvate and lonidamine lead GL15 glioblastoma cells to death by different p53-dependent routes. Sci Rep 5:14343. https://doi.org/10.1038/srep14343

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shoshan MC (2012) 3-Bromopyruvate: targets and outcomes. J Bioenerg Biomembr 44(1):7–15. https://doi.org/10.1007/s10863-012-9419-2

Article  CAS  PubMed  Google Scholar 

Petricciuolo M, Davidescu M, Fettucciari K, Gatticchi L, Brancorsini S, Roberti R, Corazzi L, Macchioni L (2020) The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells. Heliyon 6(12):e05741. https://doi.org/10.1016/j.heliyon.2020.e05741

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishiguro Y, Kobayashi M, Ideno M, Narumi K, Furugen A, Iseki K (2018) Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity. Int J Pharm 551(1–2):97–102. https://doi.org/10.1016/j.ijpharm.2018.08.039

Article  CAS  PubMed  Google Scholar 

Szoka F Jr, Papahadjopoulos D (1978) Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci U S A 75(9):4194–4198. https://doi.org/10.1073/pnas.75.9.4194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baeza I, Ibañez M, Lazcano A, Santiago C, Arguello C, Wong C, Oró J (1987) Liposomes with polyribonucleotides as model of precellular systems. Orig Life Evol Biosph 17(3–4):321–331. https://doi.org/10.1007/BF02386471

Article  CAS  PubMed  Google Scholar 

Neri-Bazán RM, García-Machorro J, Méndez-Luna D, Tolentino-López LE, Martínez-Ramos F, Padilla-Martínez II, Aguilar-Faisal L, Soriano-Ursúa MA, Trujillo-Ferrara JG, Fragoso-Vázquez MJ, Barrón BL, Correa-Basurto J (2017) Design, in silico studies, synthesis and in vitro evaluation of oseltamivir derivatives as inhibitors of neuraminidase from influenza A virus H1N1. Eur J Med Chem 128:154–167. https://doi.org/10.1016/j.ejmech.2017.01.039

Article  CAS  PubMed  Google Scholar 

Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Academic Press, San Diego

Google Scholar 

Bancroft JD, Gamble M (2002) Theory and practice of histological techniques. Churchill Livingstone, New York, p 129

Google Scholar 

Ong SG, Ming LC, Lee KS, Yuen KH (2016) Influence of the encapsulation efficiency and size of liposome on the oral bioavailability of griseofulvin-loaded liposomes. Pharmaceutics 8(3):25. https://doi.org/10.3390/pharmaceutics8030025

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Tan T, Zhao L, Liu M, You Y, Zeng Y, Chen D, Xie T, Zhang L, Fu C, Zeng Z (2020) Recent advancements in liposome-targeting strategies for the treatment of gliomas: a systematic review. ACS Appl Bio Mater 3(9):5500–5528. https://doi.org/10.1021/acsabm.0c00705

Article  CAS  PubMed 

Comments (0)

No login
gif