The long COVID haul

A subset of people who recover from SARS-CoV-2 infection experience diverse ongoing systemic and neurocognitive impairments — the so-called post-acute sequelae of COVID-19 (PASC), also referred to as ‘long COVID’. Wong et al. examined the metabolite signatures in blood of healthy control individuals, people with acute SARS-CoV-2 infection, people who had recovered fully from SARS-CoV-2 and people with PASC. Compared with control individuals, serotonin levels were substantially lower during acute infection, and remained low in people with PASC; those who recovered to a symptom-free state after COVID-19 showed normal serotonin levels.

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