Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6(5):274–85.
Article CAS PubMed Google Scholar
Velissaris D, Karamouzos V, Ktenopoulos N, Pierrakos C, Karanikolas M. The use of sodium bicarbonate in the treatment of acidosis in sepsis: a literature update on a long term debate. Crit Care Res Pract. 2015;2015:605830.
PubMed PubMed Central Google Scholar
Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309–19.
Mochizuki K, Fujii T, Paul E, Anstey M, Pilcher DV, Bellomo R. Early metabolic acidosis in critically ill patients: a binational multicentre study. Crit Care Resusc. 2021;23:67–75.
Adrogue HJ, Madias NE. Management of life-threatening acid-base disorders. Second of two parts. N Engl J Med. 1998;338(2):107–11.
Article CAS PubMed Google Scholar
Fujii T, Udy A, Licari E, Romero L, Bellomo R. Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: a scoping and a systematic review. J Crit Care. 2019;51:184–91.
Article CAS PubMed Google Scholar
Matyukhin I, Patschan S, Ritter O, Patschan D. Etiology and management of acute metabolic acidosis: an update. Kidney Blood Press Res. 2020;45(4):523–31.
Article CAS PubMed Google Scholar
Wilson RF, Spencer AR, Tyburski JG, Dolman H, Zimmerman LH. Bicarbonate therapy in severely acidotic trauma patients increases mortality. J Trauma Acute Care Surg. 2013;74(1):45–50 discussion 50.
Article CAS PubMed Google Scholar
Lo KB, Garvia V, Stempel JM, Ram P, Rangaswami J. Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: a meta analysis. Heart Lung. 2020;49(2):167–74.
Wang H, Liang R, Liang T, Chen S, Zhang Y, Zhang L, Chen C. Effectiveness of sodium bicarbonate infusion on mortality in critically ill children with metabolic acidosis. Front Pharmacol. 2022;13:759247.
Article CAS PubMed PubMed Central Google Scholar
Loomba RS, Abdulkarim M, Bronicki RA, Villarreal EG, Flores S. Impact of sodium bicarbonate therapy on hemodynamic parameters in infants: a meta-analysis. J Matern Fetal Neonatal Med. 2022;35(12):2324–30.
Article CAS PubMed Google Scholar
Jaber S, Paugam C, Futier E, Lefrant JY, Lasocki S, Lescot T, Pottecher J, Demoule A, Ferrandiere M, Asehnoune K, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet. 2018;392(10141):31–40.
Article CAS PubMed Google Scholar
Zhang Z, Zhu C, Mo L, Hong Y. Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis. Intensive Care Med. 2018;44(11):1888–95.
Article CAS PubMed Google Scholar
Bagshaw SM, Wald R, Adhikari NKJ, Investigators S-A, Canadian Critical Care Trials G, Australian, New Zealand Intensive Care Society Clinical Trials G, United Kingdom Critical Care Research G, Canadian Nephrology Trials N, Irish Critical Care Trials G, et al. Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med. 2020;383(3):240–51.
Article CAS PubMed Google Scholar
El-Solh AA, Abou Jaoude P, Porhomayon J. Bicarbonate therapy in the treatment of septic shock: a second look. Intern Emerg Med. 2010;5(4):341–7.
Mathieu D, Neviere R, Billard V, Fleyfel M, Wattel F. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study. Crit Care Med. 1991;19(11):1352–6.
Article CAS PubMed Google Scholar
Khazel AH, McLaughlin JS, Suddhimondala C, Atar S, Cowley RA. The effects of acidosis and alkalosis on cardiac output and peripheral resistance in humans. Am Surg. 1969;35(9):600–5.
Lo KB, Garvia V, Stempel JM, Ram P, Rangaswami J. Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: a meta analysis. Heart Lung. 2020;49:167–74.
Ferreruela M, Raurich JM, Ayestaran I, Llompart-Pou JA. Hyperlactatemia in ICU patients: incidence, causes and associated mortality. J Crit Care. 2017;42:200–5.
Article CAS PubMed Google Scholar
Drumheller BC, Sabolick EE. Hemodynamic instability and abnormal vasopressor responsiveness in the setting of severe metabolic acidosis treated with adapted alkalinization and continuous renal replacement therapy in the emergency department. J Emerg Med. 2021;60(1):67–72.
Castello LM, Gavelli F, Baldrighi M, Salmi L, Mearelli F, Fiotti N, Patrucco F, Bellan M, Sainaghi PP, Ronzoni G, et al. Hypernatremia and moderate-to-severe hyponatremia are independent predictors of mortality in septic patients at emergency department presentation: a sub-group analysis of the need-speed trial. Eur J Intern Med. 2021;83:21–7.
Article CAS PubMed Google Scholar
Zeng X, Yu G, Lu Y, Tan L, Wu X, Shi S, Duan H, Shu Q, Li H. PIC, a paediatric-specific intensive care database. Sci Data. 2020;7(1):14.
Article PubMed PubMed Central Google Scholar
Kellum JA. Determinants of blood pH in health and disease. Crit Care. 2000;4(1):6–14.
Article CAS PubMed PubMed Central Google Scholar
Drolz A, Horvatits T, Roedl K, Rutter K, Brunner R, Zauner C, Schellongowski P, Heinz G, Funk GC, Trauner M, et al. Acid-base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease. Ann Intensive Care. 2018;8(1):48.
Article PubMed PubMed Central Google Scholar
Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8(10):589–601.
Article CAS PubMed Google Scholar
Yagi K, Fujii T. Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy. Crit Care. 2021;25(1):314.
Article PubMed PubMed Central Google Scholar
Fujii T, Udy AA, Nichol A, Bellomo R, Deane AM, El-Khawas K, Thummaporn N, Serpa Neto A, Bergin H, Short-Burchell R, et al. Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: an international observational study. Crit Care. 2021;25(1):45.
Article PubMed PubMed Central Google Scholar
Kim HJ, Son YK, An WS. Effect of sodium bicarbonate administration on mortality in patients with lactic acidosis: a retrospective analysis. PLoS ONE. 2013;8(6):e65283.
Article CAS PubMed PubMed Central Google Scholar
Pedoto A, Caruso JE, Nandi J, Oler A, Hoffmann SP, Tassiopoulos AK, McGraw DJ, Camporesi EM, Hakim TS. Acidosis stimulates nitric oxide production and lung damage in rats. Am J Respir Crit Care Med. 1999;159(2):397–402.
Article CAS PubMed Google Scholar
Fang ZX, Li YF, Zhou XQ, Zhang Z, Zhang JS, Xia HM, Xing GP, Shu WP, Shen L, Yin GQ. Effects of resuscitation with crystalloid fluids on cardiac function in patients with severe sepsis. BMC Infect Dis. 2008;8:50.
Article PubMed PubMed Central Google Scholar
Corey HE. Stewart and beyond: new models of acid-base balance. Kidney Int. 2003;64(3):777–87.
Article CAS PubMed Google Scholar
Rein JL, Coca SG. “I don’t get no respect”: the role of chloride in acute kidney injury. Am J Physiol Renal Physiol. 2019;316(3):F587–605.
Article CAS PubMed Google Scholar
Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis - a systematic review. Ann Intensive Care. 2011;1(1):23.
Article PubMed PubMed Central Google Scholar
Duhon B, Attridge RL, Franco-Martinez AC, Maxwell PR, Hughes DW. Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. Ann Pharmacother. 2013;47:970–5.
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