Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. 2013.

Book  Google Scholar 

Hyman SL, Levy SE, Myers SM, Kuo DZ, Apkon S, Davidson LF, et al. Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics. 2020;145(1):e20193447.

Article  PubMed  Google Scholar 

Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, et al. Global prevalence of autism: a systematic review update. Autism Res. 2022;15(5):778–90.

Article  PubMed  PubMed Central  Google Scholar 

Ratto AB, Kenworthy L, Yerys BE, Bascom J, Wieckowski AT, White SW, et al. What about the girls? Sex-based differences in autistic traits and adaptive skills. J Autism Dev Disord. 2018;48(5):1698–711.

Article  PubMed  PubMed Central  Google Scholar 

Hansen SN, Schendel DE, Parner ET. Explaining the Increase in the prevalence of autism spectrum disorders. JAMA Pediatr. 2015;169(1):56.

Article  PubMed  Google Scholar 

Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P. Physiological mediators of prenatal environmental influences in autism spectrum disorder. BioEssays. 2021;43(9):2000307.

Article  Google Scholar 

Tong L, Kalish BT. The impact of maternal obesity on childhood neurodevelopment. J Perinatol. 2021;41(5):928–39.

Article  PubMed  Google Scholar 

Tioleco N, Silberman AE, Stratigos K, Banerjee-Basu S, Spann MN, Whitaker AH, et al. Prenatal maternal infection and risk for autism in offspring: a meta-analysis. Autism Res. 2021;14(6):1296–316.

Article  PubMed  Google Scholar 

Rowland J, Wilson CA. The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis. Sci Rep. 2021;11(1):5136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ponsonby A-L, Symeonides C, Saffery R, Mueller JF, O’Hely M, Sly PD, et al. Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: a birth cohort study. Neurotoxicology. 2020;80:20–8.

Article  CAS  PubMed  Google Scholar 

Hagberg KW, Robijn AL, Jick SS. Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol. 2018;10:1599–612.

Article  PubMed  PubMed Central  Google Scholar 

Hamad AF, Alessi-Severini S, Mahmud SM, Brownell M, Kuo IF. Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study. PLoS One. 2019;14(8):e0221921.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaste P, Leboyer M. Autism risk factors: genes, environment, and gene-environment interactions. Dialogues Clin Neurosci. 2012;14(3):281–92.

Article  PubMed  PubMed Central  Google Scholar 

Qiu S, Qiu Y, Li Y, Cong X. Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses. Transl Psychiatry. 2022;12(1):249.

Article  PubMed  PubMed Central  Google Scholar 

Careaga M, Murai T, Bauman MD. Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates. Biol Psychiatry. 2017;81(5):391–401.

Article  CAS  PubMed  Google Scholar 

Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P, et al. Mitochondria may mediate prenatal environmental influences in autism spectrum disorder. J Pers Med. 2021;11(3):218.

Article  PubMed  PubMed Central  Google Scholar 

Mandic-Maravic V, Mitkovic-Voncina M, Pljesa-Ercegovac M, Savic-Radojevic A, Djordjevic M, Pekmezovic T, et al. Autism spectrum disorders and perinatal complications—Is oxidative stress the connection? Front Psychiatry. 2019;10:675.

Article  PubMed  PubMed Central  Google Scholar 

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Worsham W, Dalton S, Bilder DA. The prenatal hormone milieu in autism spectrum disorder. Front Psychiatry. 2021;12:655438.

Article  PubMed  PubMed Central  Google Scholar 

Ornoy A, Weinstein-Fudim L, Ergaz Z. Prenatal factors associated with autism spectrum disorder (ASD). Reprod Toxicol. 2015;56:155–69.

Article  CAS  PubMed  Google Scholar 

Tordjman S, Somogyi E, Coulon N, Kermarrec S, Cohen D, Bronsard G, et al. Gene× Environment interactions in autism spectrum disorders: role of epigenetic mechanisms. Front Psych. 2014;5:53.

Google Scholar 

Schaaf CP, Betancur C, Yuen RKC, Parr JR, Skuse DH, Gallagher L, et al. A framework for an evidence-based gene list relevant to autism spectrum disorder. Nat Rev Genet. 2020;21(6):367–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenberg RE, Law JK, Yenokyan G, McGready J, Kaufmann WE, Law PA. Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Arch Pediatr Adolesc Med. 2009;163(10):907.

Article  PubMed  Google Scholar 

Hansen SN, Schendel DE, Francis RW, Windham GC, Bresnahan M, Levine SZ, et al. Recurrence risk of autism in siblings and cousins: a multinational, population-based study. J Am Acad Child Adolesc Psychiatry. 2019;58(9):866–75.

Article  PubMed  PubMed Central  Google Scholar 

Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med. 1995;25(1):63–77.

Article  CAS  PubMed  Google Scholar 

Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, et al. Strong association of de novo copy number mutations with autism. Science. 2007;316(5823):445–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quesnel-Vallières M, Weatheritt RJ, Cordes SP, Blencowe BJ. Autism spectrum disorder: insights into convergent mechanisms from transcriptomics. Nat Rev Genet. 2019;20(1):51–63.

Article  PubMed  Google Scholar 

Goin-Kochel RP, Abbacchi A, Constantino JN, Autism Genetic Resource Exchange C. Lack of evidence for increased genetic loading for autism among families of affected females. Autism. 2007;11(3):279–86.

Article  PubMed  Google Scholar 

Szatmari P, Liu XQ, Goldberg J, Zwaigenbaum L, Paterson AD, Woodbury-Smith M, et al. Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability. Am J Med Genet B Neuropsychiatr Genet. 2012;159(1):5–12.

Article  Google Scholar 

Baron-Cohen S, Lombardo MV, Auyeung B, Ashwin E, Chakrabarti B, Knickmeyer R. Why are autism spectrum conditions more prevalent in males? PLoS Biol. 2011;9(6):e1001081.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Napolitano A, Schiavi S, La Rosa P, Rossi-Espagnet MC, Petrillo S, Bottino F, et al. Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features. Front Psychiatry. 2022;13:889636.

Article  PubMed  PubMed Central  Google Scholar 

Cheroni C, Caporale N, Testa G. Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology. Mol Autism. 2020;11(1):69.

Article  PubMed 

Comments (0)

No login
gif