Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.

Article  Google Scholar 

Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A, Bray F. Bladder Cancer incidence and mortality: A global overview and recent trends. Eur Urol. 2017;71(1):96–108.

Article  PubMed  Google Scholar 

Zi H, He SH, Leng XY, Xu XF, Huang Q, Weng H, et al. Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019. Military Med Res. 2021;8(1):60.

Article  Google Scholar 

Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal manifestations of Inflammatory Bowel Disease: current concepts, treatment, and implications for Disease Management. Gastroenterology. 2021;161(4):1118–32.

Article  CAS  PubMed  Google Scholar 

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel Disease in the 21st century: a systematic review of population-based studies. Lancet (London England). 2017;390(10114):2769–78.

Article  PubMed  Google Scholar 

Derikx LA, Smits LJ, van Vliet S, Dekker E, Aalfs CM, van Kouwen MC, et al. Colorectal Cancer risk in patients with Lynch Syndrome and Inflammatory Bowel Disease. Clin Gastroenterol Hepatology: Official Clin Pract J Am Gastroenterological Association. 2017;15(3):454–8e1.

Article  Google Scholar 

Singh S, Nagpal SJ, Murad MH, Yadav S, Kane SV, Pardi DS, et al. Inflammatory bowel Disease is associated with an increased risk of Melanoma: a systematic review and meta-analysis. Clin Gastroenterol Hepatology: Official Clin Pract J Am Gastroenterological Association. 2014;12(2):210–8.

Article  Google Scholar 

Pedersen N, Duricova D, Elkjaer M, Gamborg M, Munkholm P, Jess T. Risk of extra-intestinal cancer in inflammatory bowel Disease: meta-analysis of population-based cohort studies. Am J Gastroenterol. 2010;105(7):1480–7.

Article  PubMed  Google Scholar 

Mosher CA, Brown GR, Weideman RA, Crook TW, Cipher DJ, Spechler SJ, et al. Incidence of Colorectal Cancer and Extracolonic cancers in veteran patients with inflammatory bowel Disease. Inflamm Bowel Dis. 2018;24(3):617–23.

Article  PubMed  Google Scholar 

Emdin CA, Khera AV, Kathiresan S. Mendelian Randomization Jama. 2017;318(19):1925–6.

Article  PubMed  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, et al. Strengthening the reporting of Observational studies in Epidemiology using mendelian randomization: the STROBE-MR Statement. JAMA. 2021;326(16):1614–21.

Article  PubMed  Google Scholar 

Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG. Using published data in mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol. 2015;30(7):543–52.

Article  PubMed  PubMed Central  Google Scholar 

Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, et al. Association analyses identify 38 susceptibility loci for inflammatory bowel Disease and highlight shared genetic risk across populations. Nat Genet. 2015;47(9):979–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel Disease in adults. Gut. 2019;68(Suppl 3):1–s106.

Article  Google Scholar 

Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.

Article  PubMed  PubMed Central  Google Scholar 

Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46(6):1985–98.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Tilling K, Davey Smith G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13(11):e1007081.

Article  PubMed  PubMed Central  Google Scholar 

Brion MJ, Shakhbazov K, Visscher PM. Calculating statistical power in mendelian randomization studies. Int J Epidemiol. 2013;42(5):1497–501.

Article  PubMed  Google Scholar 

Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG. Sensitivity analyses for robust causal inference from mendelian randomization analyses with multiple genetic variants. Epidemiol (Cambridge Mass). 2017;28(1):30–42.

Article  Google Scholar 

Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and Diseases. Nat Genet. 2018;50(5):693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coussens LM, Werb ZJN. Inflamm cancer. 2002;420(6917):860–7.

CAS  Google Scholar 

van den Heuvel TR, Wintjens DS, Jeuring SF, Wassink MH, Romberg-Camps MJ, Oostenbrug LE, et al. Inflammatory bowel Disease, cancer and medication: Cancer risk in the Dutch population‐based. IBDSL Cohort. 2016;139(6):1270–80.

Google Scholar 

Kappelman MD, Farkas DK, Long MD, Erichsen R, Sandler RS, Sørensen HT, et al. Risk of cancer in patients with inflammatory bowel Diseases: a nationwide population-based cohort study with 30 years of follow-up evaluation. Clin Gastroenterol Hepatology: Official Clin Pract J Am Gastroenterological Association. 2014;12(2):265–73e1.

Article  Google Scholar 

Madanchi M, Zeitz J, Barthel C, Samaras P, Scharl S, Sulz MC, et al. Malignancies in patients with inflammatory bowel Disease: a single-centre experience. Digestion. 2016;94(1):1–8.

Article  CAS  PubMed  Google Scholar 

Algaba A, Guerra I, Castaño A, de la Poza G, Castellano VM, López M, et al. Risk of cancer, with special reference to extra-intestinal malignancies, in patients with inflammatory bowel Disease. World J Gastroenterol. 2013;19(48):9359–65.

Article  PubMed  PubMed Central  Google Scholar 

Nesi G, Nobili S, Cai T, Caini S, Santi R. Chronic inflammation in urothelial Bladder cancer. Virchows Archiv: An International Journal of Pathology. 2015;467(6):623–33.

Article  CAS  PubMed  Google Scholar 

Liu J, Wu P, Lai S, Wang J, Wang J, Zhang Y. Identifying possible hub genes and biological mechanisms shared between Bladder cancer and inflammatory bowel Disease using machine learning and integrated bioinformatics. J Cancer Res Clin Oncol. 2023.

Heo J, Lee J, Nam YJ, Kim Y, Yun H, Lee S, et al. The CDK1/TFCP2L1/ID2 cascade offers a novel combination therapy strategy in a preclinical model of Bladder cancer. Exp Mol Med. 2022;54(6):801–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma W, Zhang W, Shen L, Liu J, Yang F, Maskey N et al. Can smoking cause differences in urine microbiome in male patients with Bladder cancer? A retrospective study. 2021;11:677605.

Wang P, Hu J, Ghadermarzi S, Raza A, O’Connell D, Xiao A, et al. Smoking and inflammatory bowel Disease: a comparison of China, India, and the USA. Dig Dis Sci. 2018;63(10):2703–13.

Article  PubMed  PubMed Central  Google Scholar 

Parkes GC, Whelan K, Lindsay JO. Smoking in inflammatory bowel Disease: impact on Disease course and insights into the aetiology of its effect. J Crohn’s Colitis. 2014;8(8):717–25.

Article  Google Scholar 

Bourrier A, Carrat F, Colombel JF, Bouvier AM, Abitbol V, Marteau P, et al. Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel Disease: a prospective observational cohort study. Aliment Pharmacol Ther. 2016;43(2):252–61.

Article  CAS  PubMed  Google Scholar 

Sun JX, Xu JZ, Liu CQ, An Y, Xu MY, Zhong XY, et al. The association between human papillomavirus and Bladder cancer: evidence from meta-analysis and two-sample mendelian randomization. J Med Virol. 2023;95(1):e28208.

Article  CAS  PubMed  Google Scholar