Benefit and harm of lymphadenectomy in intermediate risk prostate cancer: comparison of five nomograms

Mottet N, Cornford P, Briers E. EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2022.

Hövels AM, Heesakkers RaM, Adang EM, Jager GJ, Strum S, Hoogeveen YL, et al. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with Prostate cancer: a meta-analysis. Clin Radiol. 2008;63:387–95.

Article  PubMed  Google Scholar 

Johnston EW, Latifoltojar A, Sidhu HS, Ramachandran N, Sokolska M, Bainbridge A, et al. Multiparametric whole-body 3.0-T MRI in newly diagnosed intermediate- and high-risk Prostate cancer: diagnostic accuracy and interobserver agreement for nodal and metastatic staging. Eur Radiol. 2019;29:3159–69.

Article  PubMed  Google Scholar 

Thalgott M, Düwel C, Rauscher I, Heck MM, Haller B, Gafita A, et al. One-stop-shop whole-body 68 Ga-PSMA-11 PET/MRI compared with clinical nomograms for preoperative T and N staging of high-risk Prostate Cancer. J Nucl Med. 2018;59:1850–6.

Article  CAS  PubMed  Google Scholar 

Perera M, Papa N, Roberts M, Williams M, Udovicich C, Vela I, et al. Gallium-68 prostate-specific membrane Antigen Positron Emission Tomography in Advanced Prostate Cancer—updated diagnostic utility, sensitivity, specificity, and distribution of prostate-specific membrane Antigen-avid lesions: a systematic review and Meta-analysis. Eur Urol. 2020;77:403–17.

Article  PubMed  Google Scholar 

Maurer T, Gschwend JE, Rauscher I, Souvatzoglou M, Haller B, Weirich G, et al. Diagnostic efficacy of 68 Gallium-PSMA Positron Emission Tomography compared to conventional imaging for Lymph Node Staging of 130 consecutive patients with intermediate to high risk Prostate Cancer. J Urol. 2016;195:1436–43.

Article  PubMed  Google Scholar 

Di Minno A, Aveta A, Gelzo M, Tripodi L, Pandolfo SD, Crocetto F, et al. 8-Hydroxy-2-Deoxyguanosine and 8-Iso-prostaglandin F2α: putative biomarkers to assess oxidative stress damage following Robot-assisted radical prostatectomy (RARP). J Clin Med. 2022;11:6102.

Article  PubMed  PubMed Central  Google Scholar 

Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, et al. EAU-ESTRO-SIOG guidelines on Prostate Cancer. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol. 2017;71:618–29.

Article  PubMed  Google Scholar 

Fossati N, Willemse P-PM, Van den Broeck T, van den Bergh RCN, Yuan CY, Briers E, et al. The benefits and Harms of different extents of Lymph Node Dissection during Radical Prostatectomy for Prostate Cancer: a systematic review. Eur Urol. 2017;72:84–109.

Article  PubMed  Google Scholar 

Partin AW, Kattan MW, Subong EN, Walsh PC, Wojno KJ, Oesterling JE, et al. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized Prostate cancer. A multi-institutional update. JAMA. 1997;277:1445–51.

Article  CAS  PubMed  Google Scholar 

Cagiannos I, Karakiewicz P, Eastham JA, Ohori M, Rabbani F, Gerigk C, et al. A preoperative nomogram identifying decreased risk of positive pelvic lymph nodes in patients with Prostate cancer. J Urol. 2003;170:1798–803.

Article  PubMed  Google Scholar 

Briganti A, Larcher A, Abdollah F, Capitanio U, Gallina A, Suardi N, et al. Updated Nomogram Predicting Lymph Node Invasion in patients with Prostate Cancer undergoing extended pelvic lymph node dissection: the essential importance of percentage of positive cores. Eur Urol. 2012;61:480–7.

Article  PubMed  Google Scholar 

Prostate Cancer Nomograms. : Dynamic Prostate Cancer Nomogram: Coefficients | Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/nomograms/prostate/pre_op/coefficients. Accessed 23 Mar 2020.

Dindo D, Demartines N, Clavien P-A. Classification of Surgical Complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.

Article  PubMed  PubMed Central  Google Scholar 

Lee HJ, Kane CJ. How to minimize Lymphoceles and treat clinically symptomatic Lymphoceles after Radical Prostatectomy. Curr Urol Rep. 2014;15:445.

Article  PubMed  Google Scholar 

Grande P, Di Pierro GB, Mordasini L, Ferrari M, Würnschimmel C, Danuser H, et al. Prospective randomized trial comparing Titanium clips to bipolar coagulation in sealing lymphatic vessels during pelvic lymph node dissection at the time of Robot-assisted radical prostatectomy. Eur Urol. 2017;71:155–8.

Article  PubMed  Google Scholar 

Musch M, Klevecka V, Roggenbuck U, Kroepfl D. Complications of pelvic lymphadenectomy in 1,380 patients undergoing radical retropubic prostatectomy between 1993 and 2006. J Urol. 2008;179:923–8. discussion 928–929.

Article  PubMed  Google Scholar 

Capitanio U, Pellucchi F, Gallina A, Briganti A, Suardi N, Salonia A, et al. How can we predict Lymphorrhoea and clinically significant lymphocoeles after radical prostatectomy and pelvic lymphadenectomy? Clinical implications: PREDICTING LYMPHORRHOEA AND CLINICALLY SIGNIFICANT LYMPHOCOELES AFTER RRP AND PLND. BJU Int. 2011;107:1095–101.

Article  PubMed  Google Scholar 

Naselli A, Andreatta R, Introini C, Fontana V, Puppo P. Predictors of symptomatic lymphocele after lymph node excision and radical prostatectomy. Urology. 2010;75:630–5.

Article  PubMed  Google Scholar 

Danuser H, Di Pierro GB, Stucki P, Mattei A. Extended pelvic lymphadenectomy and various radical prostatectomy techniques: is pelvic drainage necessary? Extended lymphadenectomy and lymphocele formation. BJU Int. 2013;111:963–9.

Article  PubMed  Google Scholar 

Allaf ME, Palapattu GS, Trock BJ, Carter HB, Walsh PC. Anatomical extent of lymph node dissection: impact on men with clinically localized Prostate cancer. J Urol. 2004;172(5 Pt 1):1840–4.

Article  PubMed  Google Scholar 

Eden CG, Zacharakis E, Bott S. The learning curve for laparoscopic extended pelvic lymphadenectomy for intermediate- and high-risk Prostate cancer: implications for compliance with existing guidelines: learning curve for performing ePLND during LRP in men with Prostate cancer. BJU Int. 2013;112:346–54.

Article  PubMed  Google Scholar 

Heidenreich A. Identification of high-risk Prostate cancer: role of prostate-specific antigen, PSA doubling time, and PSA velocity. Eur Urol. 2008;54:976–7. discussion 978–979.

Article  PubMed  Google Scholar 

Bandini M, Marchioni M, Preisser F, Nazzani S, Tian Z, Fossati N, et al. A Head-to-head comparison of four prognostic models for prediction of Lymph Node Invasion in African American and caucasian individuals. Eur Urol Focus. 2019;5:449–56.

Article  PubMed  Google Scholar 

Briganti A, Blute ML, Eastham JH, Graefen M, Heidenreich A, Karnes JR, et al. Pelvic lymph node dissection in Prostate Cancer. Eur Urol. 2009;55:1251–65.

Article  PubMed  Google Scholar 

Barth PJ, Gerharz EW, Ramaswamy A, Riedmiller H. The influence of Lymph Node counts on the detection of pelvic lymph node Metastasis in Prostate Cancer. Pathol - Res Pract. 1999;195:633–6.

Article  CAS  PubMed  Google Scholar 

Lucciola S, Pisciotti ML, Frisenda M, Magliocca F, Gentilucci A, Del Giudice F, et al. Predictive role of node-rads score in patients with Prostate cancer candidates for radical prostatectomy with extended lymph node dissection: comparative analysis with validated nomograms. Prostate Cancer Prostatic Dis. 2023;26:379–87.

Article  PubMed  Google Scholar 

Hope TA, Eiber M, Armstrong WR, Juarez R, Murthy V, Lawhn-Heath C, et al. Diagnostic accuracy of 68 Ga-PSMA-11 PET for pelvic nodal Metastasis detection prior to radical prostatectomy and pelvic lymph node dissection: a multicenter prospective phase 3 imaging trial. JAMA Oncol. 2021;7:1635.

Article  PubMed  PubMed Central  Google Scholar 

Lombardo R, De Nunzio C. Nomograms in PCa: where do we stand. Prostate Cancer Prostatic Dis. 2023;26:447–8.

Article  PubMed  Google Scholar 

Oderda M, Diamand R, Albisinni S, Calleris G, Carbone A, Falcone M, et al. Indications for and Complications of pelvic lymph node dissection in Prostate cancer: accuracy of available nomograms for the prediction of lymph node invasion. BJU Int. 2021;127:318–25.

Article  PubMed  Google Scholar 

Gandaglia G, Fossati N, Zaffuto E, Bandini M, Dell’Oglio P, Bravi CA, et al. Development and Internal Validation of a Novel Model to identify the candidates for extended pelvic lymph node dissection in Prostate Cancer. Eur Urol. 2017;72:632–40.

Article  PubMed  Google Scholar 

Cimino S, Reale G, Castelli T, Favilla V, Giardina R, Russo GI, et al. Comparison between Briganti, Partin and MSKCC tools in predicting positive lymph nodes in Prostate cancer: a systematic review and meta-analysis. Scand J Urol. 2017;51:345–50.

Article  PubMed  Google Scholar 

Calace FP, Napolitano L, Arcaniolo D, Stizzo M, Barone B, Crocetto F, et al. Micro-ultrasound in the diagnosis and staging of prostate and Bladder Cancer: a Comprehensive Review. Med (Mex). 2022;58:1624.

Google Scholar 

Comments (0)

No login
gif