*Department of Biochemistry and Molecular Genetics, University of Colorado Denver—Anschutz Medical Campus, Aurora, CO

†Department of Surgery, University of Colorado—Anschutz Medical Campus, Aurora, CO

‡Ernest E Moore Shock Trauma Center at Denver Health, Denver, CO

§Vitalant Research Institute, Denver, CO

∥Department of Pediatrics, University of Colorado—Anschutz Medical Campus, Aurora, CO

I.S.L., F.C., and M.D. performed metabolomics and proteomics sample processing and data acquisition. I.S.L. performed all statistical analyses and generated the figures. A.C., E.E.M., P.H., and S.M. designed the experiment, established the swine model, and collected and stored the samples. I.S.L. and A.D. wrote the first draft of the manuscript, which was revised by all the other authors. All the authors contributed to the finalization of the manuscript.

Supported by W81XWH2010205 from the Department of Defense; from T32 GM008315 and RM1GM131968 by the National Institute of General Medical Sciences; from R01HL146442, R01HL149714, R01HL161004, and R01HL148151, by the National Heart, Lung, and Blood Institutes (A.D.).

A.D. and K.C.H. are founders of Omix Technologies Inc. A.D. is also a founder of Altis Biosciences LLC., A.D. is a consultant for Macopharma Inc. A.D. and C.C.S. are both consultants for Hemanext Inc. E.E.M. has received research support from Haemonetics, Werfen, Hemosonics, Stago, Diapharma, and Prytime. The remaining authors report no conflicts of interest.

[email protected].

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