Frequency, morbidity and equity — the case for increased research on male fertility

WHO. Infecundity, infertility, and childlessness in Developing Countries - DHS Comparative reports no. 9. WHO https://www.who.int/publications/m/item/infecundity-infertility-and-childlessness-in-developing-countries---dhs-comparative-reports-no.-9 (2004).

Forti, G. & Krausz, C. Clinical review 100: evaluation and treatment of the infertile couple. J. Clin. Endocrinol. Metab. 83, 4177–4188 (1998).

CAS  PubMed  Google Scholar 

De Jonge, C. & Barratt, C. L. R. The present crisis in male reproductive health: an urgent need for a political, social, and research roadmap. Andrology 7, 762–768 (2019).

Article  PubMed  Google Scholar 

Esteves, S. C. Evolution of the World Health Organization semen analysis manual: where are we? Nat. Rev. Urol. 19, 439–446 (2022).

Article  PubMed  Google Scholar 

Boitrelle, F. et al. The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis. Life 11, 1368 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eisenberg, M. L., Li, S., Behr, B., Pera, R. R. & Cullen, M. R. Relationship between semen production and medical comorbidity. Fertil. Steril. 103, 66–71 (2015).

Article  PubMed  Google Scholar 

Lismer, A. & Kimmins, S. Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development. Nat. Commun. 14, 2142 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Houston, B. J. et al. A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. Hum. Reprod. Update 28, 15–29 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Skakkebaek, N. E. et al. Environmental factors in declining human fertility. Nat. Rev. Endocrinol. 18, 139–157 (2022).

Article  PubMed  Google Scholar 

Datta, J. et al. Prevalence of infertility and help seeking among 15 000 women and men. Hum. Reprod. 31, 2108–2118 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barratt, C. L. R. et al. The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Hum. Reprod. Update 23, 660–680 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Baker, H. W. G. in Endocrinology (eds Jameson J. L. & DeGroot, L. J.) Ch. 141, 2556–2579 (Saunders Elsevier, 2010).

Bonde, J. P. et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 352, 1172–1177 (1998).

Article  CAS  PubMed  Google Scholar 

Schlegel, P. N. et al. Diagnosis and treatment of infertility in Men: AUA/ASRM guideline part I. J. Urol. 205, 36–43 (2021).

Article  PubMed  Google Scholar 

Schlegel, P. N. et al. Diagnosis and treatment of infertility in Men: AUA/ASRM guideline part II. J. Urol. 205, 44–51 (2021).

Article  PubMed  Google Scholar 

Minhas, S. et al. European Association of Urology guidelines on male sexual and reproductive health: 2021 update on male infertility. Eur. Urol. 80, 603–620 (2021).

Article  PubMed  Google Scholar 

Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion. Fertil. Steril. 103, e18–e25 (2015).

Article  Google Scholar 

Samplaski, M. K. et al. Reproductive endocrinologists are the gatekeepers for male infertility care in North America: results of a North American survey on the referral patterns and characteristics of men presenting to male infertility specialists for infertility investigations. Fertil. Steril. 112, 657–662 (2019).

Article  PubMed  Google Scholar 

Punab, M. et al. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum. Reprod. 32, 18–31 (2017).

CAS  PubMed  Google Scholar 

Campbell, M. J. et al. Distribution of semen examination results 2020 — A follow up of data collated for the WHO semen analysis manual 2010. Andrology 9, 817–822 (2021).

Article  PubMed  Google Scholar 

Bohring, C. & Krause, W. Serum levels of inhibin B in men with different causes of spermatogenic failure. Andrologia 31, 137–141 (1999).

Article  CAS  PubMed  Google Scholar 

Sikaris, K. et al. Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J. Clin. Endocrinol. Metab. 90, 5928–5936 (2005).

Article  CAS  PubMed  Google Scholar 

Waller, E.-J., Conceicao, J., Matson, P. & Yovich, J. Proposed age-stratified reference intervals of FSH derived from normozoospermic men. Asian Pac. J. Reprod. 10, 162–167 (2021).

Article  CAS  Google Scholar 

Nahoul, K. & Roger, M. Age-related decline of plasma bioavailable testosterone in adult men. J. Steroid Biochem. 35, 293–299 (1990).

Article  CAS  PubMed  Google Scholar 

Neaves, W. B., Johnson, L., Porter, J. C., Parker, C. R. Jr. & Petty, C. S. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J. Clin. Endocrinol. Metab. 59, 756–763 (1984).

Article  CAS  PubMed  Google Scholar 

Bjørnerem, A. et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromsø Study. J. Clin. Endocrinol. Metab. 89, 6039–6047 (2004).

Article  PubMed  Google Scholar 

Gray, A., Feldman, H. A., McKinlay, J. B. & Longcope, C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J. Clin. Endocrinol. Metab. 73, 1016–1025 (1991).

Article  CAS  PubMed  Google Scholar 

Andersson, A. M., Jorgensen, N., Frydelund-Larsen, L., Rajpert-De Meyts, E. & Skakkebaek, N. E. Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls. J. Clin. Endocrinol. Metab. 89, 3161–3167 (2004).

Article  CAS  PubMed  Google Scholar 

Schlegel, P. N. et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II. Fertil. Steril. 115, 62–69 (2021).

Article  PubMed  Google Scholar 

Schlegel, P. N. et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I. Fertil. Steril. 115, 54–61 (2021).

Article  PubMed  Google Scholar 

Jungwirth, A et al. EAU Guidelines on Male Infertility https://d56bochluxqnz.cloudfront.net/media/EAU-Guidelines-on-Male-Infertility-2019.pdf (EAU, 2019).

Australia and New Zealand Assisted Reproduction Database ANZARD https://www.fertilitysociety.com.au/anzard/#anzard (2019).

Nixon, B. et al. New horizons in human sperm selection for assisted reproduction. Front. Endocrinol. 14, 1145533 (2023).

Article  Google Scholar 

You, J. B. et al. Machine learning for sperm selection. Nat. Rev. Urol. 18, 387–403 (2021).

Article  PubMed  Google Scholar 

Khandwala, Y. S., Zhang, C. A., Lu, Y. & Eisenberg, M. L. The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015. Hum. Reprod. 32, 2110–2116 (2017).

Article  PubMed  Google Scholar 

Hviid Malling, G. M. et al. ‘Doing it in the right order’: childless men’s intentions regarding family formation. Hum. Fertil. 25, 188–196 (2020).

Article  Google Scholar 

Priskorn, L. et al. RUBIC (ReproUnion Biobank and Infertility Cohort): a binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. Andrology 9, 1828–1842 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Mazzilli, R. et al. Severe male factor in in vitro fertilization: definition, prevalence, and treatment. An update. Asian J. Androl. 24, 125–134 (2022).

Article  CAS  PubMed  Google Scholar 

Tournaye, H., Krausz, C. & Oates, R. D. Concepts in diagnosis and therapy for male reproductive impairment. Lancet Diabetes Endocrinol. 5, 554–564 (2017).

Article  PubMed  Google Scholar 

Young, J. et al. Clinical management of congenital hypogonadotropic hypogonadism. Endocr. Rev. 40, 669–710 (2019).

Article  PubMed  Google Scholar 

Butz, H., Nyiro, G., Kurucz, P. A., Liko, I. & Patocs, A. Molecular genetic diagnostics of hypogonadotropic hypogonadism: from panel design towards result interpretation in clinical practice. Hum. Genet. 140, 113–134 (2021).

Article  PubMed  Google Scholar 

Chudnovsky, A. & Niederberger, C. S. Gonadotropin therapy for infertile men with hypogonadotropic hypogonadism. J. Androl. 28, 644–646 (2007).

Article  PubMed  Google Scholar 

Avellino, G. J., Lipshultz, L. I., Sigman, M. & Hwang, K. Transurethral resection of the ejaculatory ducts: etiology of obstruction and surgical treatment options. Fertil. Steril. 111, 427–443 (2019).

Article  PubMed  Google Scholar 

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