Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis

Chalouhi N, Hoh BL, Hasan D. Review of cerebral aneurysm formation, growth, and rupture. Stroke. 2013;44(12):3613–22.

Article  PubMed  Google Scholar 

Shi Y, Li S, Song Y, Liu P, Yang Z, Liu Y, et al. Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function. J Neuroinflamm. 2019;16(1):185.

Article  Google Scholar 

Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2017;13(2):126.

Article  PubMed  Google Scholar 

Furukawa H, Wada K, Tada Y, Kuwabara A, Sato H, Ai J, et al. Mast cell promotes the development of intracranial aneurysm rupture. Stroke. 2020;51(11):3332–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashimoto T, Meng H, Young WL. Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling. Neurol Res. 2006;28(4):372–80.

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Peng F, Tong X, Feng X, Li Y, Chen H, et al. Associations between haemodynamics and wall enhancement of intracranial aneurysm. Stroke Vasc Neurol. 2021;6(3):467–75.

Article  PubMed  PubMed Central  Google Scholar 

Li S, Shi Y, Liu P, Song Y, Liu Y, Ying L, et al. Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway. J Neuroinflammation. 2020;17(1):191.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nirmala JG, Lopus M. Cell death mechanisms in eukaryotes. Cell Biol Toxicol. 2020;36(2):145–64.

Article  CAS  PubMed  Google Scholar 

Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–54.

Article  CAS  PubMed  Google Scholar 

Ye Y, Dai Q, Qi H. A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer. Cell Death Discov. 2021;7(1):71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–5.

Article  CAS  PubMed  Google Scholar 

Cai J, Yi M, Tan Y, Li X, Li G, Zeng Z, et al. Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-IotaIota. J Exp Clin Cancer Res. 2021;40(1):190.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Gao W, Shi X, Ding J, Liu W, He H, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547(7661):99–103.

Article  CAS  PubMed  Google Scholar 

Zhaolin Z, Guohua L, Shiyuan W, Zuo W. Role of pyroptosis in cardiovascular disease. Cell Prolif. 2019;52(2): e12563.

Article  PubMed  Google Scholar 

Le S, Zhang H, Huang X, Chen S, Wu J, Chen S, et al. PKM2 activator TEPP-46 attenuates thoracic aortic aneurysm and dissection by inhibiting NLRP3 inflammasome-mediated IL-1beta secretion. J Cardiovasc Pharmacol Ther. 2020;25(4):364–76.

Article  CAS  PubMed  Google Scholar 

Wang W, Li H, Yu L, Zhao Z, Wang H, Zhang D, et al. Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm. Oncotarget. 2017;8(2):2477–84.

Article  PubMed  Google Scholar 

Nakaoka H, Tajima A, Yoneyama T, Hosomichi K, Kasuya H, Mizutani T, et al. Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm. Stroke. 2014;45(8):2239–45.

Article  CAS  PubMed  Google Scholar 

Vargas DM, De Bastiani MA, Zimmer ER, Klamt F. Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates. Alzheimers Res Ther. 2018;10(1):59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Ding L, Liu D, Zhang Q, Zheng G, Xia X, et al. Molecular investigation of candidate genes for pyroptosis-induced inflammation in diabetic retinopathy. Front Endocrinol (Lausanne). 2022;13: 918605.

Article  PubMed  Google Scholar 

Cheng Q, Chen X, Wu H, Du Y. Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through bioinformatics analysis. J Transl Med. 2021;19(1):18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 200;102(43):15545–50.

Cong S, Guo Q, Cheng Y, Gao J, Sun L, Wang J, et al. Identification and analyzation of differentially expressed transcription factors in endometriosis. Front Mol Biosci. 2020;7: 614427.

Article  CAS  PubMed  Google Scholar 

Yang Y, Xu X. Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration. Aging (Albany, NY). 2021;13(6):8306–19.

Article  CAS  PubMed  Google Scholar 

Li H, Xu H, Li Y, Jiang Y, Hu Y, Liu T, et al. Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms. Nat Commun. 2020;11(1):3218.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu M, Peng F, Niu H, He X, Chen S, Zhang M, et al. Inflow angle impacts morphology, hemodynamics, and inflammation of side-wall intracranial aneurysms. J Magn Reson Imaging. 2023;57(1):113–23.

Article  PubMed  Google Scholar 

Frosen J, Cebral J, Robertson AM, Aoki T. Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms. Neurosurg Focus. 2019;47(1):E21.

Article  PubMed  PubMed Central  Google Scholar 

Kaminska J, Maciejczyk M, Cwiklinska A, Matowicka-Karna J, Koper-Lenkiewicz OM. Pro-inflammatory and anti-inflammatory cytokines levels are significantly altered in cerebrospinal fluid of unruptured intracranial aneurysm (UIA) patients. J Inflamm Res. 2022;15:6245–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang S, Liu Q, Yang J, Wu J, Wang S. Increased levels of serum IL-15 and TNF-beta indicate the progression of human intracranial aneurysm. Front Aging Neurosci. 2022;14: 903619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santiago-Sim T, Mathew-Joseph S, Pannu H, Milewicz DM, Seidman CE, Seidman JG, et al. Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm. Strock. 2009;40(5):1604–11.

Article  CAS  Google Scholar 

Zeng W, Wu D, Sun Y, Suo Y, Yu Q, Zeng M, et al. The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages. Sci Rep. 2021;11(1):19305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao F, Wang L, Wu Z, Luo G, Qian Y, He X, et al. Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis. Cardiovasc Drugs Ther. 2022. https://doi.org/10.1007/s10557-022-07352-w.

Qian Z, Zhao Y, Wan C, Deng Y, Zhuang Y, Xu Y, et al. Pyroptosis in the initiation and progression of atherosclerosis. Front Pharmacol. 2021;12: 652963.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty A, Li Y, Zhang C, Li Y, LeMaire SA, Shen YH. Programmed cell death in aortic aneurysm and dissection: a potential therapeutic target. J Mol Cell Cardiol. 2022;163:67–80.

Article  CAS  PubMed  Google Scholar 

Motta V, Soares F, Sun T, Philpott DJ. NOD-like receptors: versatile cytosolic sentinels. Physiol Rev. 2015;95(1):149–78.

Article  PubMed  Google Scholar 

Xue Y, Enosi TD, Tan WH, Kay C, Man SM. Emerging activators and regulators of inflammasomes and pyroptosis. Trends Immunol. 2019;40(11):1035–52.

Article  CAS  PubMed  Google Scholar 

Kannoth S, Thomas SV. Intracranial microbial aneurysm (infectious aneurysm): current options for diagnosis and management. Neurocrit Care. 2009;11(1):120–9.

Article  PubMed  Google Scholar 

Rice CJ, Cho SM, Marquardt RJ, Zhang LQ, Khoury J, Hardman J, et al. Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment. J Neurol Sci. 2019;403:50–5.

Article  PubMed  Google Scholar 

Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 2021;6(1):128.

Article 

Comments (0)

No login
gif