Coriddi M, Dayan J, Bloomfield E, McGrath L, Diwan R, Monge J, et al. Efficacy of immediate lymphatic reconstruction to decrease incidence of breast cancer-related lymphedema: preliminary results of randomized controlled trial. Ann Surg [Internet]. 2023 [cited 2025 Feb 27];278:630–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527595/
Kissin MW, Della Rovere GQ, Easton D, Westbury G. Risk of lymphoedema following the treatment of breast cancer. Br J Surg [Internet]. 1986 [cited 2025 Apr 28];73:580–4. Available from: https://doi.org/10.1002/bjs.1800730723
Montagna G, Zhang J, Sevilimedu V, Charyn J, Abbate K, Gomez EA, et al. Risk Factors and Racial and Ethnic Disparities in Patients With Breast Cancer–Related Lymphedema. JAMA Oncol [Internet]. 2022 [cited 2025 May 14];8:1195–200. Available from: https://doi.org/10.1001/jamaoncol.2022.1628
Ridner SH. The Psycho-Social Impact of Lymphedema. Lymphat Res Biol [Internet]. 2009 [cited 2025 Apr 28];7:109–12. Available from: https://www.liebertpub.com/doi/10.1089/lrb.2009.0004
Kalemikerakis I, Evaggelakou A, Kavga A, Vastardi M, Konstantinidis T, Govina O. Diagnosis, treatment and quality of life in patients with cancer-related lymphedema. J BUON Off J Balk Union Oncol. 2021;26:1735–41.
Hoyle E, Kilbreath S, Dylke E. Body image and sexuality concerns in women with breast cancer-related lymphedema: a cross-sectional study. Support Care Cancer [Internet]. 2022 [cited 2025 Apr 28];30:3917–24. Available from: https://doi.org/10.1007/s00520-021-06751-3
Fish ML, Grover R, Schwarz GS. Quality-of-life outcomes in surgical vs nonsurgical treatment of breast cancer–related lymphedema: a systematic review. JAMA Surg [Internet]. 2020 [cited 2025 Apr 28];155:513–9. Available from: https://doi.org/10.1001/jamasurg.2020.0230
Mayrovitz HN. Noninvasive Measurements of Breast Cancer-Related Lymphedema. Cureus [Internet]. 2021 [cited 2025 Apr 28];13. Available from: https://www.cureus.com/articles/76682-noninvasive-measurements-of-breast-cancer-related-lymphedema
Shah C, Whitworth P, Valente S, Schwarz GS, Kruse M, Kohli M, et al. Bioimpedance spectroscopy for breast cancer-related lymphedema assessment: clinical practice guidelines. Breast Cancer Res Treat [Internet]. 2023 [cited 2025 Apr 28];198:1–9. Available from: https://doi.org/10.1007/s10549-022-06850-7
Lahtinen T, Seppälä J, Viren T, Johansson K. Experimental and Analytical Comparisons of Tissue Dielectric Constant (TDC) and Bioimpedance Spectroscopy (BIS) in Assessment of Early Arm Lymphedema in Breast Cancer Patients after Axillary Surgery and Radiotherapy. Lymphat Res Biol [Internet]. 2015 [cited 2025 Apr 28];13:176–85. Available from: https://www.liebertpub.com/doi/10.1089/lrb.2015.0019
Mayrovitz HN, Berdichevskiy G, Lorenzo-Valido C, Clavijo Fernandez M. Heat-related changes in skin tissue dielectric constant (TDC). Clin Physiol Funct Imaging [Internet]. 2020 [cited 2025 Apr 28];40:76–82. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/cpf.12605
Toro C, Markarian B, Mayrovitz HN, Toro C, Markarian B, Mayrovitz HN. Breast Cancer-Related Lymphedema Assessed via Tissue Dielectric Constant Measurements. Cureus [Internet]. 2024 [cited 2025 Apr 28];16. Available from: https://www.cureus.com/articles/246618-breast-cancer-related-lymphedema-assessed-via-tissue-dielectric-constant-measurements
Deacon R, de Noronha M, Shanley L, Young K. Does the speed of aquatic therapy exercise alter arm volume in women with breast cancer related lymphoedema? A cross-over randomized controlled trial. Braz J Phys Ther [Internet]. 2019 [cited 2025 Apr 28];23:140–7. Available from: https://www.sciencedirect.com/science/article/pii/S1413355518303708
Rockson SG, Keeley V, Kilbreath S, Szuba A, Towers A. Cancer-associated secondary lymphoedema. Nat Rev Dis Primer [Internet]. 2019 [cited 2025 Apr 28];5:1–16. Available from: https://www.nature.com/articles/s41572-019-0072-5
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database Syst Rev. 2015;2015:CD003475.
PubMed PubMed Central Google Scholar
Rafn BS, Bodilsen A, Heymann A von, Lindberg MJ, Byllov S, Andreasen TG, et al. Examining the efficacy of treatments for arm lymphedema in breast cancer survivors: an overview of systematic reviews with meta-analyses. eClinicalMedicine [Internet]. 2024 [cited 2025 Apr 28];67. Available from: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00574-6/fulltext
Sedef Selcuk Yilmaz FFA. The Randomized Controlled Study of Low-Level Laser Therapy, Kinesio-Taping and Manual Lymphatic Drainage in Patients With Stage II Breast Cancer-Related Lymphedema [Internet]. European Journal of Breast Health; 2023 [cited 2025 Apr 28]. Available from: https://eurjbreasthealth.com/articles/doi/ejbh.galenos.2022.2022-6-4
Lee KW, Kim SB, Lee JH, Kim YS. Effects of Extracorporeal Shockwave Therapy on Improvements in Lymphedema, Quality of Life, and Fibrous Tissue in Breast Cancer-Related Lymphedema. Ann Rehabil Med [Internet]. 2020 [cited 2025 Apr 28];44:386–92. Available from: https://doi.org/10.5535/arm.19213
Malicka I, Rosseger A, Hanuszkiewicz J, Woźniewski M. Kinesiology Taping reduces lymphedema of the upper extremity in women after breast cancer treatment: a pilot study. Menopause Rev Menopauzalny [Internet]. 2014 [cited 2025 Apr 28];13:221–6. Available from: https://www.termedia.pl/Kinesiology-Taping-reduces-lymphedema-of-the-upper-extremity-in-women-after-breast-cancer-treatment-a-pilot-study,4,23461,1,1.html
Wang Y, Ge Y, Xing W, Liu J, Wu J, Lin H, et al. The effectiveness and safety of low-level laser therapy on breast cancer–related lymphedema: An overview and update of systematic reviews. Lasers Med Sci [Internet]. 2022 [cited 2025 Apr 28];37:1389–413. Available from: https://doi.org/10.1007/s10103-021-03446-3
Hou S, Li Y, Lu W, Zhang X, Luo H, Qiu J, et al. Efficacy of intermittent pneumatic compression on breast cancer-related upper limb lymphedema: a systematic review and meta-analysis in clinical studies. Gland Surg [Internet]. 2024 [cited 2025 Apr 28];13:1358369–1351369. Available from: https://gs.amegroups.org/article/view/128173
Saraswathi V, Latha S, Niraimathi K, Vidhubala E. Managing Lymphedema, Increasing Range of Motion, and Quality of Life through Yoga Therapy among Breast Cancer Survivors: A Systematic Review. Int J Yoga [Internet]. 2021 [cited 2025 Apr 28];14:3. Available from: https://journals.lww.com/ijoy/fulltext/2021/14010/managing_lymphedema,_increasing_range_of_motion,.2.aspx
Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg Chic Ill. 1960;1992(127):392–9.
Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Costantino JP, et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol [Internet]. 2010 [cited 2025 Feb 27];11:927–33. Available from: https://www.sciencedirect.com/science/article/pii/S1470204510702072
Veronesi U, Viale G, Paganelli G, Zurrida S, Luini A, Galimberti V, et al. Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg. 2010;251:595–600.
Wijaya WA, Peng J, He Y, Chen J, Cen Y. Clinical application of axillary reverse mapping in patients with breast cancer: A systematic review and meta-analysis. The Breast [Internet]. 2020 [cited 2025 Apr 28];53:189–200. Available from: https://www.thebreastonline.com/article/S0960-9776(20)30160-0/fulltext
Giuliano AE, Ballman KV, McCall L, Beitsch PD, Brennan MB, Kelemen PR, et al. Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA [Internet]. 2017 [cited 2025 Apr 28];318:918–26. Available from: https://doi.org/10.1001/jama.2017.11470
Bartels SAL, Donker M, Poncet C, Sauvé N, Straver ME, van de Velde CJH, et al. Radiotherapy or Surgery of the Axilla After a Positive Sentinel Node in Breast Cancer: 10-Year Results of the Randomized Controlled EORTC 10981–22023 AMAROS Trial. J Clin Oncol [Internet]. 2023 [cited 2025 Apr 28];41:2159–65. Available from: https://ascopubs.org/doi/10.1200/JCO.22.01565
Gentilini OD, Botteri E, Sangalli C, Galimberti V, Porpiglia M, Agresti R, et al. Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND randomized clinical trial. JAMA Oncol [Internet]. 2023 [cited 2025 May 10];9:1557–64. Available from: https://doi.org/10.1001/jamaoncol.2023.3759
Reimer T, Stachs A, Veselinovic K, Kühn T, Heil J, Polata S, et al. Axillary surgery in breast cancer - primary results of the INSEMA trial. N Engl J Med. 2025;392:1051–64.
Reimer T, Stachs A, Veselinovic K, Polata S, Müller T, Kühn T, et al. Patient-reported outcomes for the Intergroup Sentinel Mamma study (INSEMA): a randomised trial with persistent impact of axillary surgery on arm and breast symptoms in patients with early breast cancer. EClinicalMedicine. 2023;55:101756.
Lipman K, Luan A, Stone K, Wapnir I, Karin M, Nguyen D. Lymphatic microsurgical preventive healing approach (LYMPHA) for lymphedema prevention after axillary lymph node dissection-a single institution experience and feasibility of technique. J Clin Med. 2021;11:92.
Article PubMed PubMed Central Google Scholar
Feldman S, Bansil H, Ascherman J, Grant R, Borden B, Henderson P, et al. Single institution experience with lymphatic microsurgical preventive healing approach (LYMPHA) for the primary prevention of lymphedema. Ann Surg Oncol [Internet]. 2015 [cited 2025 Apr 28];22:3296–301. Available from: https://doi.org/10.1245/s10434-015-4721-y
Boccardo FM, Casabona F, Friedman D, Puglisi M, De Cian F, Ansaldi F, et al. Surgical prevention of arm lymphedema after breast cancer treatment. Ann Surg Oncol [Internet]. 2011 [cited 2025 Apr 28];18:2500–5. Available from: https://doi.org/10.1245/s10434-011-1624-4
Boccardo F, Casabona F, De Cian F, Friedman D, Murelli F, Puglisi M, et al. Lymphatic microsurgical preventing healing approach (LYMPHA) for primary surgical prevention of breast cancer-related lymphedema: over 4 years follow-up. Microsurgery. 2014;34:421–4.
Herremans KM, Cribbin MP, Riner AN, Neal DW, Hollen TL, Clevenger P, et al. Five-year breast surgeon experience in lympha at time of alnd for treatment of clinical T1–4N1–3M0 Breast Cancer. Ann Surg Oncol [Internet]. 2021 [cited 2025 Apr 28];28:5775–87. Available from: https://doi.org/10.1245/s10434-021-10551-8
Ozmen T, Lazaro M, Zhou Y, Vinyard A, Avisar E. Evaluation of simplified lymphatic microsurgical preventing healing approach (S-LYMPHA) for the prevention of breast cancer–related clinical lymphedema after axillary lymph node dissection. Ann Surg [Internet]. 2019 [cited 2025 Feb 20];270:1156. Available from: https://journals.lww.com/annalsofsurgery/abstract/2019/12000/evaluation_of_simplified_lymphatic_microsurgical.33.aspx
Ozmen T, Layton C, Friedman-Eldar O, Melnikau S, Kesmodel S, Moller MG, et al. Evaluation of simplified lymphatic microsurgical preventing healing approach (SLYMPHA) for the prevention of breast cancer-related lymphedema after axillary lymph node dissection using bioimpedance spectroscopy. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2022;48:1713–7.
Thompson M, Korourian S, Henry-Tillman R, Adkins L, Mumford S, Westbrook KC, et al. Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation. Ann Surg Oncol [Internet]. 2007 [cited 2025 Feb 27];14:1890–5. Available from: https://doi.org/10.1245/s10434-007-9412-x
Nos C, Lesieur B, Clough KB, Lecuru F. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection. Ann Surg Oncol [Internet]. 2007 [cited 2025 Feb 27];14:2490–6. Available from: https://doi.org/10.1245/s10434-007-9450-4
Tummel E, Ochoa D, Korourian S, Betzold R, Adkins L, McCarthy M, et al. Does axillary reverse mapping prevent lymphedema after lymphadenectomy? Ann Surg. 2017;265:987–92.
Co M, Lam L, Suen D, Kwong A. Axillary reverse mapping in the prevention of lymphoedema: a systematic review and pooled analysis. Clin Breast Cancer. 2023;23:e14–9.
Beek MA, Gobardhan PD, Schoenmaeckers EJP, Klompenhouwer EG, Rutten HJT, Voogd AC, et al. Axillary reverse mapping in axillary surgery for breast cancer: an update of the current status. Breast Cancer Res Treat. 2016;158:421–32.
Pons G, Condrea S, Masia J. Risk reducing lymphedema surgery: preliminary results with Targeted Lymphatic Axillary Repair (T-LAR) approach. Italy: Naples; 2022.
Pons G, Martínez-Jaimez P, Condrea S, Masia J. Immediate lymphatic reconstruction with targeted lymphatic axillary repair. J Plast Reconstr Aesthetic Surg JPRAS. 2025;101:134–40.
Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Ashikaga T, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007;8:881–8.
Article CAS PubMed Google Scholar
DiSipio T, Rye S, Newman B, Hayes S. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol. 2013;14:500–15.
Montagna G, Lee MK, Sevilimedu V, Barrio AV, Morrow M. Is Nodal Clipping Beneficial for Node-Positive Breast Cancer Patients Receiving Neoadjuvant Chemotherapy? Ann Surg Oncol. 2022;29:6133–9.
Article PubMed PubMed Central Google Scholar
Nanda A, Marshall E, Alradi D, Rusby J, Krupa K, Tasoulis M, et al. Lymphoedema Rates Following Targeted Axillary Dissection in Breast Cancer Patients. Eur J Surg Oncol [Internet]. 2024 [cited 2025 Mar 20];50. Available from: https://www.ejso.com/article/S0748-7983(24)01008-4/fulltext
Ahmed KS, Marcinak CT, LoConte NK, Krebsbach JK, Virani SS, Schiefelbein AM, et al. Colon Cancer Survival Among South Asian Americans: A Cross-Sectional Analysis of a National Dataset. J Surg Res [Internet]. 2024 [cited 2025 Jan 8];299:269–81. Available from: https://www.journalofsurgicalresearch.com/article/S0022-4804(24)00222-1/fulltext
Becker C, Vasile JV, Levine JL, Batista BN, Studinger RM, Chen CM, et al. Microlymphatic Surgery for the Treatment of Iatrogenic Lymphedema. Clin Plast Surg [Internet]. 2012 [cited 2025 Apr 28];39:385–98. Available from: https://www.plasticsurgery.theclinics.com/article/S0094-1298(12)00105-8/abstract
Granzow JW, Soderberg JM, Kaji AH, Dauphine C. An Effective System of Surgical Treatment of Lymphedema. Ann Surg Oncol [Internet]. 2014 [cited 2025 Apr 28];21:1189–94. Available from: https://doi.org/10.1245/s10434-014-3515-y
Markkula SP, Leung N, Allen VB, Furniss D. Surgical interventions for the prevention or treatment of lymphoedema after breast cancer treatment - Markkula, SP - 2019 | Cochrane Library. [cited 2025 Apr 28]; Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011433.pub2/full
Dionyssiou D, Demiri E, Tsimponis A, Sarafis A, Mpalaris V, Tatsidou G, et al. A randomized control study of treating secondary stage II breast cancer-related lymphoedema with free lymph node transfer. Breast Cancer Res Treat [Internet]. 2016 [cited 2025 Apr 28];156:73–9. Available from: https://doi.org/10.1007/s10549-016-3716-0
Ciudad P, Agko M, Perez Coca JJ, Manrique OJ, Chang W-L, Nicoli F, et al. Comparison of long-term clinical outcomes among different vascularized lymph node transfers: 6-year experience of a single center’s approach to the treatment of lymphedema. J Surg Oncol. 2017;116:671–82.
Chang EI, Skoracki RJ, Chang DW. Lymphovenous Anastomosis Bypass Surgery. Semin Plast Surg [Internet]. 2018 [cited 2025 Apr 28];32:22–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891648/
Deldar R, Spoer D, Gupta N, Towfighi P, Boisvert M, Wehner P, et al. Prophylactic Lymphovenous Bypass at the Time of Axillary Lymph Node Dissection Decreases Rates of Lymphedema. Ann Surg Open [Internet]. 2023 [cited 2025 Feb 27];4:e278. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431289/
Cho M-J, Senger J-L, Park KU, Hansotia K, Chratian S, Kadle R, et al. Preventing breast cancer-related lymphedema: a comprehensive analysis of a 9-year single-center experience of prophylactic lymphovenous bypass. Ann Surg Oncol [Internet]. 2025 [cited 2025 Apr 28];32:2007–15. Available from: https://doi.org/10.1245/s10434-024-16640-8
Chun MJ, Saeg F, Miller D, Jardak C, Duplechain A, Sultan A, et al. Surgical Lymphedema Treatment: A Meta-Analysis and Recommendations. Eplasty [Internet]. 2022 [cited 2025 Apr 28];22:e51. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071600/
La-Anyane O, Alba BE, Harmon KA, To J, Siotos C, Adepoju J, et al. United States insurance coverage of immediate lymphatic reconstruction. J Surg Oncol [Internet]. 2024 [cited 2025 Apr 28];129:584–91. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.27512
Chiang SN, Skolnick GB, Westman AM, Sacks JM, Christensen JM. National Outcomes of Prophylactic Lymphovenous Bypass during Axillary Lymph Node Dissection. J Reconstr Microsurg [Internet]. 2022 [cited 2025 Apr 28];38:613–20. Available from: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1742730
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