To determine the relation between acute phase reactant like CRP inthe first trimester as a screening test for gestational diabetes mellitus.

A prospective observational study was conducted between December 2020 to August 2022, which included healthy pregnant women who visited Lady Goschen hospital and Kasturba Medical college Attavar, Mangalore for their antenatal. Check-ups and counselling After obtaining informed consent, a detailed history and a physical examination was done to rule out all possible causes of the elevated CRP levels levels were measured by HS ELISA,and they were screened for gestational diabetes mellitus at 24–28 weeks. Association was tested between CRP positive patients and patients diagnosed with Gestational Diabetes Mellitus.

Out of 196 patients included in the study,55(27.3%) patients were diagnosed with GDM.Out of 55 patients,14 was found to be CRP positive. P value was. Found to be 0.000 which was statistically significant.

In this study association was found between inflammation in first trimester which was detected by rise in the CRP and subsequent risk of development of GDM. It could be a useful test for prediction of GDM. Specificity was found to be higher but sensitivity was found to be low, hence it may not be an ideal screening test.